Cited by 726Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

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Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., Cinti, S.·2008·Journal of Lipid Research

DOI 10.1194/jlr.m800019-jlr200

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Abstract

Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that >90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders.

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Authors: Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., & Cinti, S.
Affiliations: Marche Polytechnic University (IT)
Corresponding author: Cinti, S.
ORCID: Cinti, S.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2008-07
Volume: 49
Issue: 7
Pages: 1562-1568
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.m800019-jlr200
OpenAlex: W2138673784
Cited by: 726
References: 30
Citations by year: 2026: 26 · 2025: 43 · 2024: 52 · 2023: 46 · 2022: 65 · 2021: 52 · 2020: 58 · 2019: 47 · 2018: 45 · 2017: 48 · 2016: 32 · 2015: 37 · 2014: 28 · 2013: 43 · 2012: 29
FWCI: 18.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4465 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Funders: Università Politecnica delle Marche
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: crown-like structures, visceral fat, subcutaneous adipose tissue, adipocyte death, macrophage infiltration, obesity, db/db mice, ob/ob mice, adipocyte size, chronic inflammation, insulin resistance, adipose tissue
MeSH terms: Animals, Female, Mice, Obese, Cell Death, Adipocytes, Intra-Abdominal Fat, Mice

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Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

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