Cited by 726Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

Open access

Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., Cinti, S.·2008·Journal of Lipid Research

DOI 10.1194/jlr.m800019-jlr200

Open this paper in CoChat — free account Open PDF

Abstract

Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that >90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1194/jlr.m800019-jlr200

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Self-citation
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,071
Advances in Male Contraception
Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,138
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007
The biology of white adipocyte proliferation
Hausman, D. B., DiGirolamo, M., Bartness, T. J., Hausman, G., & Martin, R. J. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00042.x · Cited by 724
Understanding and Addressing the Epidemic of Obesity: An Energy Balance Perspective
Hill, J. O. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0032 · Cited by 610

Show all 30 references

Sorted by citations

Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066
Adipose tissue inflammation and metabolic dysfunction in obesity
Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947
Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Wang, T., & He, C. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.002 · Cited by 1,034
Obesity, Adipose Tissue and Vascular Dysfunction
Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 979
Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications
Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 939
Autophagy regulates adipose mass and differentiation in mice
Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 765
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 691
Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype
Ohashi, K., Parker, J. L., Ouchi, N., Higuchi, A., Vita, J. A., Gokce, N., Pedersen, A. A., Kalthoff, C., Tullin, S., Sams, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088708 · Cited by 646
Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
Amano, S. U., Cohen, J. L., Vangala, P., Tencerová, M., Nicoloro, S. M. C., Yawe, J. C., Shen, Y., Czech, M., & Aouadi, M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.017 · Cited by 605
The inflammation highway: metabolism accelerates inflammatory traffic in obesity
Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603
Adipokines: A link between obesity and cardiovascular disease
Nakamura, K., Fuster, J. J., & Walsh, K. X. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.11.006 · Cited by 597
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2011 · Cited by 591
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 578
The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
Johnson, B. Z., Stevenson, A. W., Prêle, C. M., Fear, M. W., & Wood, F. M. (2020) · Biomedicines · doi:10.3390/biomedicines8050101 · Cited by 557
Immune Regulation of Metabolic Homeostasis in Health and Disease
Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 510
Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer
Morris, P. G., Hudis, C. A., Giri, D. D., Morrow, M., Falcone, D. J., Zhou, X. K., Du, B., Brogi, E., Crawford, C. B., Kopelovich, L., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0110 · Cited by 473
Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice
Saberi, M., Woods, N.-B., de Luca, C., Schenk, S., Lu, J. C., Bandyopadhyay, G., Verma, I. M., & Olefsky, J. M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.006 · Cited by 456
Obesity and the risk of cardiometabolic diseases
Valenzuela, P. L., Carrera-Bastos, P., Castillo-García, A., Lieberman, D. E., Santos-Lozano, A., & Lucia, A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00847-5 · Cited by 452
Adipose tissue macrophages: going off track during obesity
Boutens, L., & Stienstra, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3904-9 · Cited by 452
Adaptive immunity in obesity and insulin resistance
Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486
Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity
Rogers, N. H., Perfield, J. W., Strissel, K. J., Obin, M. S., & Greenberg, A. S. (2009) · Endocrinology · doi:10.1210/en.2008-1405 · Cited by 427
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394
Transdifferentiation properties of adipocytes in the adipose organ
Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379
Self-citation
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution
Sárvári, A. K., Hauwaert, E. L. V., Markussen, L. K., Gammelmark, E., Marcher, A.-B., Ebbesen, M. F., Nielsen, R., Brewer, J. R., Madsen, J. G. S., & Mandrup, S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.004 · Cited by 377
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461
Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis
Alkhouri, N., Górnicka, A., Berk, M. P., Thapaliya, S., Dixon, L. J., Kashyap, S. R., Schauer, P. R., & Feldstein, A. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074252 · Cited by 369
Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland
Subbaramaiah, K., Howe, L. R., Bhardwaj, P., Du, B., Gravaghi, C., Yantiss, R. K., Zhou, X. K., Blaho, V. A., Hla, T., Yang, P., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0381 · Cited by 362
Retracted
The adipose organ at a glance
Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 370
Self-citation
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
Park, J., Euhus, D., & Scherer, P. E. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0030 · Cited by 361
Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer
Howe, L. R., Subbaramaiah, K., Hudis, C. A., & Dannenberg, A. J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2603 · Cited by 347
Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
Kern, L., Mittenbühler, M., Vesting, A., Ostermann, A., Wunderlich, C., & Wunderlich, F. (2018) · Cancers · doi:10.3390/cancers11010024 · Cited by 331
Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae
DeFuria, J., Bennett, G., Strissel, K. J., James, W. P., Milbury, P. E., Greenberg, A. S., & Obin, M. S. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.105155 · Cited by 313
Mechanisms of Inflammatory Responses in Obese Adipose Tissue
Sun, S., Ji, Y., Kersten, S., & Qi, L. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 322
Macrophage infiltration into adipose tissue: initiation, propagation and remodeling
Surmi, B. K., & Hasty, A. H. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.545 · Cited by 307
Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
Giordano, A., Murano, I., Mondini, E., Perugini, J., Smorlesi, A., Severi, I., Barazzoni, R., Scherer, P. E., & Cinti, S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m038638 · Cited by 297
Self-citation
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation
Kotzbeck, P., Giordano, A., Mondini, E., Murano, I., Severi, I., Venema, W., Cecchini, M. P., Kershaw, E. E., Barbatelli, G., Haemmerle, G., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m079665 · Cited by 303
Self-citation
Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity.
Coats, B. R., Schoenfelt, K. Q., Barbosa-Lorenzi, V. C., Peris, E., Cui, C., Hoffman, A., Zhou, G., Fernandez, S., Zhai, L., Hall, B. A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.096 · Cited by 291
Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review
Fain, J. N. (2010) · Mediators of Inflammation · doi:10.1155/2010/513948 · Cited by 299
MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ
Giordano, A., Smorlesi, A., Frontini, A., Barbatelli, G., & Cinti, S. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0945 · Cited by 298
Self-citation
Cell death and inflammation during obesity: “Know my methods, WAT(son)”
Hildebrandt, X., Ibrahim, M. A., & Peltzer, N. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01062-4 · Cited by 307
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 290
Macrophages, Chronic Inflammation, and Insulin Resistance
He, L., Meng, Y., He, S., Tan, X., Zhang, Y., Zhang, X., Wang, L., & Zheng, W. (2022) · Cells · doi:10.3390/cells11193001 · Cited by 286
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258
Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
Nishimoto, S., Fukuda, D., Higashikuni, Y., Tanaka, K., Hirata, Y., Murata, C., Kim‐Kaneyama, J., Sato, F., Bando, M., Yagi, S., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501332 · Cited by 259
Adipocyte biology in breast cancer: From silent bystander to active facilitator
Choi, J., Cha, Y. J., & Koo, J. S. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.11.002 · Cited by 260
Insulin dysregulation
Frank, N., & Tadros, E. M. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12169 · Cited by 260
Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance
Kim, S. M., Lun, M., Wang, M., Senyo, S. E., Guillermier, C., Patwari, P., & Steinhauser, M. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.010 · Cited by 259
Increased Levels of COX-2 and Prostaglandin E2 Contribute to Elevated Aromatase Expression in Inflamed Breast Tissue of Obese Women
Subbaramaiah, K., Morris, P. G., Zhou, X. K., Morrow, M., Du, B., Giri, D. D., Kopelovich, L., Hudis, C. A., & Dannenberg, A. J. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0241 · Cited by 242
Retracted
Aging and Regional Differences in Fat Cell Progenitors – A Mini-Review
Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M., & Kirkland, J. L. (2011) · Gerontology · doi:10.1159/000279755 · Cited by 232
White adipose tissue dysfunction in obesity and aging
Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114723 · Cited by 250
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity
Braune, J., Weyer, U., Hobusch, C., Mauer, J., Brüning, J. C., Bechmann, I., & Gericke, M. T. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600476 · Cited by 241
Convertible visceral fat as a therapeutic target to curb obesity
Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 241
Self-citation
The autocrine and paracrine roles of adipokines
Karastergiou, K., & Mohamed-Ali, V. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.011 · Cited by 233
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis
Truax, A. D., Chen, L., Tam, J. W., Cheng, N., Guo, H., Koblansky, A. A., Chou, W.-C., Wilson, J. E., Brickey, W. J., Petrucelli, A., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.08.009 · Cited by 228
Role of Adaptive and Innate Immunity in Type 2 Diabetes Mellitus
Zhou, T., Hu, Z., Yang, S., Sun, L., Yu, Z., & Wang, G. (2018) · Journal of Diabetes Research · doi:10.1155/2018/7457269 · Cited by 243
Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction
Komiya, C., Tsuchiya, K., Shiba, K., Miyachi, Y., Furuke, S., Shimazu, N., Yamaguchi, S., Kanno, K., & Ogawa, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151511 · Cited by 232
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
Basseri, S., Lhoták, Š., Sharma, A. M., & Austin, R. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900216-jlr200 · Cited by 228
Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study
Favero, M., Hadi, H. E., Belluzzi, E., Granzotto, M., Porzionato, A., Sarasin, G., Rambaldo, A., Iacobellis, C., Cigolotti, A., Fontanella, C. G., et al. (2017) · Rheumatology · doi:10.1093/rheumatology/kex287 · Cited by 219
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
Gauthier, M., O’Brien, E. L., Bigornia, S., Mott, M. M., Cacicedo, J. M., Xu, X. J., Gokce, N., Apovian, C. M., & Ruderman, N. B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.127 · Cited by 212
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis
Tanaka, M., Ikeda, K., Suganami, T., Komiya, C., Ochi, K., Shirakawa, I., Hamaguchi, M., Nishimura, S., Manabe, I., Matsuda, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5982 · Cited by 206
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
Colleluori, G., & Villareal, D. T. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111561 · Cited by 217
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200
Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice
Altintas, M. M., Azad, A., Nayer, B., Contreras, G., Zaias, J., Faul, C., Reiser, J., & Nayer, A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011338 · Cited by 198
The initiation of metabolic inflammation in childhood obesity
Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194
The Role of the Immune System in Obesity and Insulin Resistance
Patel, P., Buras, E. D., & Balasubramanyam, A. (2013) · Journal of Obesity · doi:10.1155/2013/616193 · Cited by 201
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188
Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease
Farrell, G. C., Haczeyni, F., & Chitturi, S. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-8684-7_3 · Cited by 178
The adipose organ: white‐brown adipocyte plasticity and metabolic inflammation
Smorlesi, A., Frontini, A., Giordano, A., & Cinti, S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01039.x · Cited by 189
Self-citation
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171
Similarities and interplay between senescent cells and macrophages
Behmoaras, J., & Gil, J. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202010162 · Cited by 158
The immune system's involvement in obesity-driven type 2 diabetes
Shu, C. J., Benoist, C. O., & Mathis, D. J. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.12.001 · Cited by 170
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Self-citation
Obesity and corticosteroids: 11β-Hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
Morton, N. M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.024 · Cited by 168
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets
Khan, S. U., Shukla, S., Sinha, S., & Meeran, S. M. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.10.001 · Cited by 164
Between brown and white: Novel aspects of adipocyte differentiation
Cinti, S. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.535557 · Cited by 169
Self-citation
Diabetes and inflammation: Fundamental aspects and clinical implications
Garcia, C., Fève, B., Ferré, P., Halimi, S., Baïzri, H., Bordier, L., Guiu, G., Dupuy, O., Bauduceau, B., & Mayaudon, H. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.07.001 · Cited by 167
Immune Regulation in Obesity-Associated Adipose Inflammation
Han, J. M., & Levings, M. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301035 · Cited by 162
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 181
Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype
Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 154
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
DeBari, M. K., & Abbott, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176030 · Cited by 153
Macrophages, Meta-Inflammation, and Immuno-Metabolism
Shapiro, H., Lutaty, A., & Ariel, A. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/397971 · Cited by 153
The Impact of Obesity on Breast Cancer
Argolo, D. F. S. D. T. E., Hudis, C. A., & Iyengar, N. M. (2018) · Current Oncology Reports · doi:10.1007/s11912-018-0688-8 · Cited by 145
Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity
Orliaguet, L., Dalmas, É., Drareni, K., Venteclef, N., & Alzaïd, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00062 · Cited by 151
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages
Lindhorst, A., Raulien, N., Wieghofer, P., Eilers, J., Rossi, F. M. V., Bechmann, I., & Gericke, M. T. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03872-9 · Cited by 163
M1/M2 macrophage polarization in human obese adipose tissue
Chylíková, J., Dvořáčková, J., Tauber, Z., & Kamarád, V. (2018) · Biomedical Papers · doi:10.5507/bp.2018.015 · Cited by 143
Inflammaging: The ground for sarcopenia?
Liang, Z., Zhang, T., Liu, H., Li, Z., Peng, L., Wang, C., & Wang, T. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111931 · Cited by 156
DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria
Karakasilioti, I., Kamileri, I., Chatzinikolaou, G., Kosteas, T., Vergadi, E., Robinson, A. R., Tsamardinos, I., Rozgaja, T. A., Siakouli, S., Tsatsanis, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.011 · Cited by 143
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137
Adipose tissue in obesity and obstructive sleep apnoea
Bonsignore, M. R., McNicholas, W. T., Montserrat, J. M., & Eckel, J. (2011) · European Respiratory Journal · doi:10.1183/09031936.00047010 · Cited by 141
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 143
Adipose tissue macrophage in obesity-associated metabolic diseases
Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151
Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages
Fischer‐Posovszky, P., Wang, Q. A., Asterholm, I. W., Rutkowski, J. M., & Scherer, P. E. (2011) · Endocrinology · doi:10.1210/en.2011-1031 · Cited by 138
Role of macrophage tissue infiltration in obesity and insulin resistance
Bourlier, V., & Bouloumié, A. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.05.001 · Cited by 141
Macrophage activation in human diseases
Schultze, J. L., Schmieder, A., & Goerdt, S. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.07.003 · Cited by 134

Authors: Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., & Cinti, S.
Affiliations: Marche Polytechnic University (IT)
Corresponding author: Cinti, S.
ORCID: Cinti, S.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2008-07
Volume: 49
Issue: 7
Pages: 1562-1568
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.m800019-jlr200
OpenAlex: W2138673784
Cited by: 726
References: 30
Citations by year: 2026: 26 · 2025: 43 · 2024: 52 · 2023: 46 · 2022: 65 · 2021: 52 · 2020: 58 · 2019: 47 · 2018: 45 · 2017: 48 · 2016: 32 · 2015: 37 · 2014: 28 · 2013: 43 · 2012: 29
FWCI: 18.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4465 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Funders: Università Politecnica delle Marche
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: crown-like structures, visceral fat, subcutaneous adipose tissue, adipocyte death, macrophage infiltration, obesity, db/db mice, ob/ob mice, adipocyte size, chronic inflammation, insulin resistance, adipose tissue
MeSH terms: Animals, Female, Mice, Obese, Cell Death, Adipocytes, Intra-Abdominal Fat, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks