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Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
Open accessAbstract
Accumulation of visceral fat is a key phenomenon in the onset of obesity-associated metabolic disorders. Macrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that >90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders.
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“As dead adipocytes are detected within CLS (Murano et al., 2008)”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Murano et al., 2008
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Harness, E. (2015) · OpenCommons - UConn (University of Connecticut)
Metadata
- Authors
- Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., & Cinti, S.
- Affiliations
- Marche Polytechnic University (IT)
- Corresponding author
- Cinti, S.
- ORCID
- Cinti, S.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 49
- Issue
- 7
- Pages
- 1562-1568
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2138673784
- Cited by
- 726
- References
- 30
- Citations by year
- 2026: 26 · 2025: 43 · 2024: 52 · 2023: 46 · 2022: 65 · 2021: 52 · 2020: 58 · 2019: 47 · 2018: 45 · 2017: 48 · 2016: 32 · 2015: 37 · 2014: 28 · 2013: 43 · 2012: 29
- FWCI
- 18.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- Università Politecnica delle Marche
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- crown-like structures, visceral fat, subcutaneous adipose tissue, adipocyte death, macrophage infiltration, obesity, db/db mice, ob/ob mice, adipocyte size, chronic inflammation, insulin resistance, adipose tissue
- MeSH terms
- Animals, Female, Mice, Obese, Cell Death, Adipocytes, Intra-Abdominal Fat, Mice
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