The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry
Open accessAbstract
Previous studies have shown that MALDI-imaging mass spectrometry (IMS) can be used to visualize the distribution of various biomolecules, especially lipids, in the cells and tissues. In this study, we report the cell-selective distribution of PUFA-containing glycerophospholipids (GPLs) in the mouse brain. We established a practical experimental procedure for the IMS of GPLs. We demonstrated that optimization of the composition of the matrix solution and spectrum normalization to the total ion current (TIC) is critical. Using our procedure, we simultaneously differentiated and visualized the localizations of specific molecular species of GPLs in mouse brain sections. The results showed that PUFA-containing phosphatidylcholines (PCs) were distributed in a cell-selective manner: arachidonic acid- and docosahexaenoic acid-containing PCs were seen in the hippocampal neurons and cerebellar Purkinje cells, respectively. Furthermore, these characteristic localizations of PUFA-PCs were formed during neuronal maturation. The phenomenon of brain cell-selective production of specific PUFA-GPLs will help elucidate the potential physiological functions of PUFAs in specific brain regions.
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Cites
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Brain monoglyceride lipase participating in endocannabinoid inactivation
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., & Piomelli, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152334899 · Cited by 1,373
Mechanisms of action of docosahexaenoic acid in the nervous system
Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919
Han, X., & Gross, R. W. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300004-jlr200 · Cited by 914
Cited by
Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution
Niehaus, M., Soltwisch, J., Belov, M. E., & Dreisewerd, K. (2019) · Nature Methods · doi:10.1038/s41592-019-0536-2 · Cited by 429
Phosphatidylserine in the brain: Metabolism and function
Kim, H.-Y., Huang, B. X., & Spector, A. A. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.06.002 · Cited by 389
MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry
Zemski Berry, K. A., Hankin, J. A., Barkley, R. M., Spraggins, J. M., Caprioli, R. M., & Murphy, R. C. (2011) · Chemical Reviews · doi:10.1021/cr200280p · Cited by 386
Xu, D., Omura, T., Masaki, N., Arima, H., Banno, T., Okamoto, A., Hanada, M., Takei, S., Matsushita, S., Sugiyama, E., et al. (2016) · Scientific Reports · doi:10.1038/srep26427 · Cited by 34
Self-citationGonzález de San Román, E., Bidmon, H.-J., Malisic, M., Susnea, I., Küppers, A., Hübbers, R., Wree, A., Nischwitz, V., Amunts, K., & Huesgen, P. F. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1660-y · Cited by 24
Metadata
- Authors
- Sugiura, Y., Konishi, Y., Zaima, N., Kajihara, S., Nakanishi, H., Taguchi, R., & Setou, M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 50
- Issue
- 9
- Pages
- 1776-1788
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1986581829
- Cited by
- 201
- References
- 4
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sugiura, Y., Konishi, Y., Zaima, N., Kajihara, S., Nakanishi, H., Taguchi, R., & Setou, M. (2009). Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. Journal of Lipid Research. https://doi.org/10.1194/jlr.m900047-jlr200
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