Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury
Open accessAbstract
Peripheral nerve injury (PNI) triggers cellular and molecular changes in the spinal cord. However, little is known about how the polyunsaturated fatty acid-containing phosphatidylcholines (PUFA-PCs) are regulated in the spinal cord after PNI and the association of PUFA-PCs with the non-neuronal cells within in the central nervous system (CNS). In this study, we found that arachidonic acid-containing phosphatidylcholine (AA-PC), [PC(16:0/20:4)+K]+, was significantly increased in the ipsilateral ventral and dorsal horns of the spinal cord after sciatic nerve transection and the increased expression of [PC(16:0/20:4)+K]+ spatiotemporally resembled the increase of reactive microglia and the astrocytes. From the lipidomics point of view, we conclude that [PC(16:0/20:4)+K]+ could be the main phospholipid in the spinal cord influenced by PNI and the regulation of specific phospholipid molecule in the CNS after PNI is associated with the reactive microglia and astrocytes.
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PC was increased in LPL KD cells.
“Additionally, phosphatidylcholine (PC), which is known to alter the size and dynamics of LDs [43], and is a feature of reactive microglia [44], was increased in LPL KD cells (Figure 2E,J).”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [44]
The citation [44] supports the statement about PC and reactive microglia, not the citing authors’ Figure 2 observation in LPL KD cells. The Results report an increase in a specific arachidonic acid-containing PC after nerve injury, and the Discussion says its pattern resembled reactive microglia. The Discussion also says the study could not identify which cells produced the increase, so it does not establish PC generally as a feature of reactive microglia. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPC alters the size and dynamics of LDs and is a feature of reactive microglia.
“Additionally, phosphatidylcholine (PC), which is known to alter the size and dynamics of LDs [43], and is a feature of reactive microglia [44], was increased in LPL KD cells (Figure 2E,J).”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [44]
The Discussion reports that arachidonic acid-containing PC increased alongside reactive microglia in the spinal cord after peripheral nerve injury, and concludes that it could reflect reactive microglia and astrocytes. This supports the part attributed to [44], but not the broader implication that PC generally is a feature of reactive microglia. The lipid-droplet claim is attributed to [43], not this source. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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- Authors
- Xu, D., Omura, T., Masaki, N., Arima, H., Banno, T., Okamoto, A., Hanada, M., Takei, S., Matsushita, S., Sugiyama, E., Setou, M., & Matsuyama, Y.
- Affiliations
- Hamamatsu University (JP)
- Corresponding author
- Setou, Mitsutoshi
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-05-23
- Volume
- 6
- Issue
- 1
- Pages
- 26427-26427
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4876408
- OpenAlex
- W2406516931
- Cited by
- 34
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HamaMed-Repository (Hamamatsu University School of Medicine) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Agency for Medical Research and Development (CREST, 921910520)
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- peripheral nerve injury, sciatic nerve transection, spinal cord, reactive microglia, reactive astrocytes, phospholipid metabolism, lipidomics, ventral horn, dorsal horn
- MeSH terms
- Animals, Astrocytes, Disease Models, Animal, Female, Phosphatidylcholines, Spinal Cord, Arachidonic Acid, Microglia, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Lipid Metabolism, Mice, Peripheral Nerve Injuries
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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