The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation
Open accessAbstract
Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the spatial and temporal distribution of phospholipid species associated with mouse embryo implantation. Molecular images showing phospholipid distribution within implantation sites changed markedly between distinct cellular areas during days 4-8 of pregnancy. For example, by day 8, linoleate- and docosahexaenoate-containing phospholipids localized to regions destined to undergo cell death, whereas oleate-containing phospholipids localized to angiogenic regions. Arachidonate-containing phospholipids showed different segregation patterns depending on the lipid class, revealing a strong correlation of phosphatidylethanolamines and phosphatidylinositols with cytosolic phospholipase A(2alpha) and cyclooxygenase-2 during embryo implantation. LC-ESI-MS/MS was used to validate MALDI IMS phospholipid distribution patterns. Overall, molecular images revealed the dynamic complexity of lipid distributions in early pregnancy, signifying the importance of complex interplay of lipid molecules in uterine biology and implantation.
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Cites
Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
Self-citationTime of Implantation of the Conceptus and Loss of Pregnancy
Wilcox, A. J., Baird, D. D., & Weinberg, C. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402304 · Cited by 1,081
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
Khan, W. A., Blobe, G. C., & Hannun, Y. A. (1995) · Cellular Signalling · doi:10.1016/0898-6568(94)00089-t · Cited by 225
Cited by
MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry
Zemski Berry, K. A., Hankin, J. A., Barkley, R. M., Spraggins, J. M., Caprioli, R. M., & Murphy, R. C. (2011) · Chemical Reviews · doi:10.1021/cr200280p · Cited by 386
Self-citationMALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives
Seeley, E. H., & Caprioli, R. M. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2010.12.002 · Cited by 197
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Metadata
- Authors
- Burnum, K. E., Cornett, D. S., Puolitaival, S. M., Milne, S. B., Myers, D. S., Tranguch, S., Brown, H. A., Dey, S. K., & Caprioli, R. M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 50
- Issue
- 11
- Pages
- 2290-2298
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2110797862
- Cited by
- 158
- References
- 4
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Burnum, K. E., Cornett, D. S., Puolitaival, S. M., Milne, S. B., Myers, D. S., Tranguch, S., Brown, H. A., Dey, S. K., & Caprioli, R. M. (2009). Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. Journal of Lipid Research. https://doi.org/10.1194/jlr.m900100-jlr200
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