The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
Open accessAbstract
We previously reported that adenosine monophosphate-activated protein kinase (AMPK) activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant than in comparably obese people who are insulin sensitive. However, the number of patients and parameters studied were small. Here, we compared abdominal subcutaneous, epiploic, and omental fat from 16 morbidly obese individuals classified as insulin sensitive or insulin resistant based on the homeostatic model assessment of insulin resistance. We confirmed that AMPK activity is diminished in the insulin resistant group. A custom PCR array revealed increases in mRNA levels of a wide variety of genes associated with inflammation and decreases in PGC-1α and Nampt in omental fat of the insulin resistant group. In contrast, subcutaneous abdominal fat of the same patients showed increases in PTP-1b, VEGFa, IFNγ, PAI-1, and NOS-2 not observed in omental fat. Only angiotensinogen and CD4(+) mRNA levels were increased in both depots. Surprisingly, TNFα was only increased in epiploic fat, which otherwise showed very few changes. Protein carbonyl levels, a measure of oxidative stress, were increased in all depots. Thus, adipose tissues of markedly obese insulin resistant individuals uniformly show decreased AMPK activity and increased oxidative stress compared with insulin sensitive patients. However, most changes in gene expression appear to be depot-specific.
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AMPK, insulin resistance, and the metabolic syndrome
Ruderman, N. B., Carling, D., Prentki, M., & Cacicedo, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67227 · Cited by 873
Self-citationWu, L., Zhang, L., Li, B., Jiang, H., Duan, Y., Xie, Z., Shuai, L., Li, J., & Li, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00122 · Cited by 255
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250
Insulin Signal Transduction Perturbations in Insulin Resistance
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Metadata
- Authors
- Xu, X. J., Gauthier, M.-S., Hess, D. T., Apovian, C. M., Cacicedo, J. M., Gokce, N., Farb, M., Valentine, R. J., & Ruderman, N. B.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 53
- Issue
- 4
- Pages
- 792-801
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2162576384
- Cited by
- 229
- References
- 18
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xu, X. J., Gauthier, M.-S., Hess, D. T., Apovian, C. M., Cacicedo, J. M., Gokce, N., Farb, M., Valentine, R. J., & Ruderman, N. B. (2012). Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. Journal of Lipid Research. https://doi.org/10.1194/jlr.p022905
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