The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
AMPK, insulin resistance, and the metabolic syndrome
Open accessAbstract
Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as are central adiposity, dyslipidemia, and a predisposition to type 2 diabetes, atherosclerotic cardiovascular disease, hypertension, and certain cancers. Regular exercise and calorie restriction have long been known to increase insulin sensitivity and decrease the prevalence of these disorders. The subsequent identification of AMP-activated protein kinase (AMPK) and its activation by exercise and fuel deprivation have led to studies of the effects of AMPK on both IR and metabolic syndrome-related diseases. In this review, we evaluate this body of literature, with special emphasis on the hypothesis that dysregulation of AMPK is both a pathogenic factor for these disorders in humans and a target for their prevention and therapy.
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Cites
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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Self-citationProgress and challenges in translating the biology of atherosclerosis
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Cited by
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Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Kim, H.-S., Quon, M. J., & Kim, J.-A. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.022 · Cited by 804
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592
“AMPK activation generates insulin-sensitizing effects resulting in increased glucose uptake in skeletal muscles, and decreased hepatic glucose production and enhanced fatty acid oxidation in several tissues (Ruderman & Prentki, 2004; Ruderman et al. , 2013).”
The essential role of exercise in the management of type 2 diabetes
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Metadata
- Authors
- Ruderman, N. B., Carling, D., Prentki, M., & Cacicedo, J. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-07-01
- Volume
- 123
- Issue
- 7
- Pages
- 2764-2772
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2057218469
- Cited by
- 873
- References
- 44
- FWCI
- 29.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ruderman, N. B., Carling, D., Prentki, M., & Cacicedo, J. M. (2013). AMPK, insulin resistance, and the metabolic syndrome. Journal of Clinical Investigation. https://doi.org/10.1172/jci67227
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
