Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

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ESC/EAS Guidelines for the management of dyslipidaemias

Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549 · see citing works

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227 · see citing works

Effect of Two Intensive Statin Regimens on Progression of Coronary Disease

Nicholls, S. J., Ballantyne, C. M., Barter, P. J., Chapman, M. J., Erbel, R. M., Libby, P., Raichlen, J. S., Uno, K., Borgman, M., Wolski, K., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1110874 · Cited by 896 · see citing works

Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial

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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

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Metabolite Profiling and Cardiovascular Event Risk

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Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study

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The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)—methods and response rates

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Metabolic Syndrome Is Associated with Elevated Oxidative Stress and Dysfunctional Dense High-Density Lipoprotein Particles Displaying Impaired Antioxidative Activity

Hansel, B., Giral, P., Nobécourt, E., Chantepie, S., Bruckert, É., Chapman, M. J., & Kontush, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0305 · Cited by 476 · see citing works

Risks Associated With Statin Therapy: A Systematic Overview of Randomized Clinical Trials

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Small, Dense HDL Particles Exert Potent Protection of Atherogenic LDL Against Oxidative Stress

Kontush, A., Chantepie, S., & Chapman, M. J. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000091338.93223.e8 · Cited by 452 · see citing works

Plasma lipid profiling in a large population-based cohort

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Genetic and Environmental Contributions to Cardiovascular Risk Factors in Mexican Americans

Mitchell, B. D., Kammerer, C. M., Blangero, J., Mahaney, M. C., Rainwater, D. L., Dyke, B., Hixson, J. E., Henkel, R. D., Sharp, R. M., Comuzzie, A. G., et al. (1996) · Circulation · doi:10.1161/01.cir.94.9.2159 · Cited by 364 · see citing works

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

Cederberg, H., Stančáková, A., Yaluri, N., Modi, S. R., Kuusisto, J., & Laakso, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3528-5 · Cited by 316 · see citing works

Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus

Navarese, E. P., Buffon, A., Andreotti, F., Koziński, M., Welton, N. J., Fabiszak, T., Caputo, S., Grześk, G., Kubica, A., Świątkiewicz, I., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.037 · Cited by 309 · see citing works

Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes

Meikle, P. J., Wong, G., Barlow, C. K., Weir, J. M., Greeve, M. A., MacIntosh, G. L., Almasy, L. A., Comuzzie, A. G., Mahaney, M. C., Kowalczyk, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074341 · Cited by 308 · see citing works

Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease

Meikle, P. J., Wong, G., Tsorotes, D., Barlow, C. K., Weir, J. M., Christopher, M., MacIntosh, G. L., Goudey, B., Stern, L., Kowalczyk, A., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.234096 · Cited by 306 · see citing works

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

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Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

Chapman, M. J., Le Goff, W., Guerin, M., & Kontush, A. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp399 · Cited by 298 · see citing works

Comparative Tolerability and Harms of Individual Statins: A Study-Level Network Meta-Analysis of 246 955 Participants From 135 Randomized, Controlled Trials

Naci, H., Brugts, J., & Ades, T. (2013) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.111.000071 · Cited by 292 · see citing works

Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database

Barter, P. J., Brandrup-Wognsen, G., Palmer, M. K., & Nicholls, S. J. (2010) · Journal of Lipid Research · doi:10.1194/jlr.p002816 · Cited by 259 · see citing works

Preferential Sphingosine-1-Phosphate Enrichment and Sphingomyelin Depletion Are Key Features of Small Dense HDL3 Particles

Kontush, A., Thérond, P., Zerrad-Saadi, A., Couturier, M., Nègre‐Salvayre, A., Souza, J. A., Chantepie, S., & Chapman, M. J. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145672 · Cited by 228 · see citing works

Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease

Meikle, P. J., Wong, G., Barlow, C. K., & Kingwell, B. A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.001 · Cited by 185 · see citing works

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

de Mello, V. D., Lankinen, M. A., Schwab, U., Kolehmainen, M., Lehto, S., Seppänen‐Laakso, T., Orešič, M., Pulkkinen, L., Uusitupa, M. I. J., & Erkkilä, A. T. (2009) · Diabetologia · doi:10.1007/s00125-009-1482-9 · Cited by 182 · see citing works

Cardiovascular Event Reduction Versus New-Onset Diabetes During Atorvastatin Therapy

Waters, D. D., Ho, J. E., Boekholdt, S. M., DeMicco, D. A., Kastelein, J. J. P., Messig, M., Breazna, A., & Pedersen, T. R. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.042 · Cited by 178 · see citing works

Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?

Li, N., Fu, J., Koonen, D. P. Y., Kuivenhoven, J. A., Snieder, H., & Hofker, M. H. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.013 · Cited by 177 · see citing works

Statin Therapy in Acute Coronary Syndromes

Sposito, A. C., & Chapman, M. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000032033.39301.6a · Cited by 159 · see citing works

HDL3-Mediated Inactivation of LDL-Associated Phospholipid Hydroperoxides Is Determined by the Redox Status of Apolipoprotein A-I and HDL Particle Surface Lipid Rigidity

Zerrad-Saadi, A., Thérond, P., Chantepie, S., Couturier, M., Rye, K., Chapman, M. J., & Kontush, A. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194555 · Cited by 159 · see citing works

HDL Phospholipid Content and Composition as a Major Factor Determining Cholesterol Efflux Capacity From Fu5AH Cells to Human Serum

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Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo

Pynn, C. J., Henderson, N., Clark, H. W., Koster, G., Bernhard, W., & Postle, A. D. (2010) · Journal of Lipid Research · doi:10.1194/jlr.d011916 · Cited by 150 · see citing works

Physiological roles of phosphatidylethanolamine N-methyltransferase

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Plasma Sphingomyelin and Subclinical Atherosclerosis: Findings from the Multi-Ethnic Study of Atherosclerosis

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Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes

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Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: Impact on small HDL particles

Ståhlman, M., Fagerberg, B., Adiels, M., Ekroos, K., Chapman, J., Kontush, A., & Borén, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.009 · Cited by 120 · see citing works

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism

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The use of statins in people at risk of developing diabetes mellitus: Evidence and guidance for clinical practice

Sattar, N. A., Ginsberg, H. N., Ray, K. K., Chapman, M. J., Arca, M., Averna, M. R., Betteridge, D. J., Bhatnagar, D., Bilianou, E., Carmena, R., et al. (2014) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2014.04.001 · Cited by 98 · see citing works

Effect of Two Intensive Statin Regimens on Progression of Coronary Disease

Nicholls, S. J., Ballantyne, C. M., Barter, P. J., Chapman, M. J., Erbel, R. M., Libby, P., Raichlen, J. S., Uno, K., Borgman, M., Wolski, K., et al. (2012) · Survey of Anesthesiology · doi:10.1097/01.sa.0000414260.89578.71 · Cited by 95 · see citing works

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

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Delay of copper-catalyzed oxidation of low density lipoprotein by in vitro enrichment with choline or ethanolamine plasmalogens

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Effect of high-dose pitavastatin on glucose homeostasis in patients at elevated risk of new-onset diabetes: insights from the CAPITAIN and PREVAIL-US studies

Chapman, M. J., Orsoni, A., Robillard, P., Hounslow, N. J., Sponseller, C. A., & Giral, P. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.874989 · Cited by 44 · see citing works

Modulation of endothelial permeability by 1‐O‐alkylglycerols

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TRENDS IN DOOR-TO-BALLOON TIME AND OUTCOMES FOLLOWING PRIMARY PCI FOR STEMI

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Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

Meikle, P. J., & Summers, S. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.169 · Cited by 426 · see citing works

MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines

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Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development

Holmes, M. V., Richardson, T. G., Ference, B. A., Davies, N. M., & Davey Smith, G. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00493-1 · Cited by 184 · see citing works

Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial

Fujino, T., Yamada, T., Asada, T., Tsuboi, Y., Wakana, C., Mawatari, S., & Kono, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.02.012 · Cited by 150 · see citing works

Sphingolipid metabolism in non-alcoholic fatty liver diseases

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A distinct plasma lipid signature associated with poor prognosis in castration‐resistant prostate cancer

Lin, H., Mahon, K. L., Weir, J. M., Mundra, P. A., Spielman, C., Briscoe, K. P., Gurney, H., Mallesara, G., Marx, G. M., Stockler, M. R., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30903 · Cited by 84 · see citing works

LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL

Chapman, M. J., Orsoni, A., Tan, R., Mellett, N. A., Nguyen, A., Robillard, P., Giral, P., Thérond, P., & Meikle, P. J. (2020) · Journal of Lipid Research · doi:10.1194/jlr.p119000543 · Cited by 65 · see citing works

Lipidomes in health and disease: Analytical strategies and considerations

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Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

Lin, H., Mak, B., Yeung, N. K., Huynh, K., Meikle, T. G., Mellett, N. A., Kwan, E. M., Fettke, H., Tran, B., Davis, I. D., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103625 · Cited by 55 · see citing works

Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes

Grace, M. S., Dempsey, P. C., Sethi, P., Mundra, P. A., Mellett, N. A., Weir, J. M., Owen, N. G., Dunstan, D. W., Meikle, P. J., & Kingwell, B. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3926 · Cited by 55 · see citing works

Dietary Interventions Reduce Traditional and Novel Cardiovascular Risk Markers by Altering the Gut Microbiome and Their Metabolites

Vijay, A., Astbury, S., Louca, P., Marques, F. Z., Spector, T. D., Menni, C., & Valdes, A. M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.691564 · Cited by 44 · see citing works

Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations

Moxon, J. V., Jones, R. E., Wong, G., Weir, J. M., Mellett, N. A., Kingwell, B. A., Meikle, P. J., & Golledge, J. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.925 · Cited by 43 · see citing works

Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes

Ziegler, D., Strom, A., Straßburger, K., Knebel, B., Bönhof, G. J., Kotzka, J., Szendroedi, J., Roden, M., & for the German Diabetes Study group (2020) · Diabetologia · doi:10.1007/s00125-020-05310-5 · Cited by 40 · see citing works

Pitavastatin: A Review in Hypercholesterolemia

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Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia

Orsoni, A., Thérond, P., Tan, R., Giral, P., Robillard, P., Kontush, A., Meikle, P. J., & Chapman, M. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.p068585 · Cited by 37 · see citing works

Sphingolipids as Biomarkers of Disease

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Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics

Lee, H., Choi, J. M., Cho, J., Kim, T., Lee, H. J., & Jung, B. H. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2018.05.005 · Cited by 33 · see citing works

Exacerbation of Nanoparticle-Induced Acute Pulmonary Inflammation in a Mouse Model of Metabolic Syndrome

Alqahtani, S., Kobos, L. M., Xia, L., Ferreira, C. R., Franco, J., Du, X., & Shannahan, J. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00818 · Cited by 33 · see citing works

The Cardiac Lipidome in Models of Cardiovascular Disease

Tomczyk, M. M., & Dolinsky, V. W. (2020) · Metabolites · doi:10.3390/metabo10060254 · Cited by 33 · see citing works

Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer

Lin, H., Huynh, K., Kohli, M., Tan, W. W., Azad, A., Yeung, N. K., Mahon, K. L., Mak, B., Sutherland, P. D., Shepherd, A., et al. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00338-z · Cited by 31 · see citing works

LC-MS-Based Untargeted Metabolomics Reveals Early Biomarkers in STZ-Induced Diabetic Rats With Cognitive Impairment

Chen, R., Zeng, Y., Xiao, W., Zhang, L., & Shu, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.665309 · Cited by 30 · see citing works

Role of Ceramides in the Molecular Pathogenesis and Potential Therapeutic Strategies of Cardiometabolic Diseases: What we Know so Far

Shalaby, Y. M., Aidaros, A. A., Valappil, A., Ali, B. R., & Akawi, N. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.816301 · Cited by 30 · see citing works

Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease

Borja, M. S., Hammerson, B., Tang, C., Savinova, O. V., Shearer, G. C., & Oda, M. N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182217 · Cited by 27 · see citing works

Systematic review and meta-analysis of studies assessing the relationship between statin use and risk of ovarian cancer

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Ceramides may Play a Central Role in the Pathogenesis of Alzheimer’s Disease: a Review of Evidence and Horizons for Discovery

Kalkman, H. O., & Smigielski, L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04989-0 · Cited by 29 · see citing works

Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data

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Changes in plasma lipids predict pravastatin efficacy in secondary prevention

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Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Mak, B., Lin, H., Kwan, E. M., Fettke, H., Tran, B., Davis, I. D., Mahon, K. L., Stockler, M. R., Briscoe, K. P., Marx, G. M., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02298-0 · Cited by 21 · see citing works

Molecular Characterization of Plasma HDL, LDL, and VLDL Lipids Cargos from Atherosclerotic Patients with Advanced Carotid Lesions: A Preliminary Report

Nieddu, G., Michelucci, E., Formato, M., Ciampelli, C., Obino, G., Signore, G., Giorgi, N. D., Rocchiccioli, S., & Lepedda, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012449 · Cited by 20 · see citing works

Searching for Atherosclerosis Biomarkers by Proteomics: A Focus on Lesion Pathogenesis and Vulnerability

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Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

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