The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Ketogenic diets, mitochondria, and neurological diseases
Open accessAbstract
The ketogenic diet (KD) is a broad-spectrum therapy for medically intractable epilepsy and is receiving growing attention as a potential treatment for neurological disorders arising in part from bioenergetic dysregulation. The high-fat/low-carbohydrate "classic KD", as well as dietary variations such as the medium-chain triglyceride diet, the modified Atkins diet, the low-glycemic index treatment, and caloric restriction, enhance cellular metabolic and mitochondrial function. Hence, the broad neuroprotective properties of such therapies may stem from improved cellular metabolism. Data from clinical and preclinical studies indicate that these diets restrict glycolysis and increase fatty acid oxidation, actions which result in ketosis, replenishment of the TCA cycle (i.e., anaplerosis), restoration of neurotransmitter and ion channel function, and enhanced mitochondrial respiration. Further, there is mounting evidence that the KD and its variants can impact key signaling pathways that evolved to sense the energetic state of the cell, and that help maintain cellular homeostasis. These pathways, which include PPARs, AMP-activated kinase, mammalian target of rapamycin, and the sirtuins, have all been recently implicated in the neuroprotective effects of the KD. Further research in this area may lead to future therapeutic strategies aimed at mimicking the pleiotropic neuroprotective effects of the KD.
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Cites
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Sirtuins as regulators of metabolism and healthspan
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Anticonvulsant Mechanisms of the Ketogenic Diet
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Self-citationD-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
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Cited by
Kossoff, E. H., Zupec‐Kania, B. A., Auvin, S., Ballaban‐Gil, K. R., Christina Bergqvist, A. G., Blackford, R., Buchhalter, J. R., Caraballo, R. H., Cross, J. H., Dahlin, M. G., et al. (2018) · Epilepsia Open · doi:10.1002/epi4.12225 · Cited by 768
Self-citationTargeting LDH enzymes with a stiripentol analog to treat epilepsy
Sada, N., Lee, S., Katsu, T., Otsuki, T., & Inoue, T. (2015) · Science · doi:10.1126/science.aaa1299 · Cited by 413
Ketogenic Diet in Alzheimer’s Disease
Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163892 · Cited by 319
Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
Newell, C., Bomhof, M. R., Reimer, R. A., Hittel, D. S., Rho, J. M., & Shearer, J. (2016) · Molecular Autism · doi:10.1186/s13229-016-0099-3 · Cited by 272
Schönfeld, P., & Reiser, G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.018 · Cited by 99
Metadata
- Authors
- Gano, L. B., Patel, M., & Rho, J. M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 55
- Issue
- 11
- Pages
- 2211-2228
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2153413087
- Cited by
- 277
- References
- 16
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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