Intestinal transport and metabolism of bile acids

The biosynthesis of ethyl esters of lithocholic acid and isolithocholic acid by rat intestinal microflora

Kelsey, M. I., & Sexton, S. A. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90059-5 · Cited by 38

Profiles of bile acids and their glucuronide and sulphate conjugates in the serum, urine and bile from patients undergoing bile drainage.

Takikawa, H., Beppu, T., & Seyama, Y. (1985) · Gut · doi:10.1136/gut.26.1.38 · Cited by 38

Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

Zhang, Y., Limaye, P. B., Lehman‐McKeeman, L. D., & Klaassen, C. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034522 · Cited by 37

Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis

Marschall, H., Broomé, U., Einarsson, C., Alvélius, G., Thomas, H. G., & Matern, S. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31635-7 · Cited by 37

6α-Glucuronidation of hyodeoxycholic acid by human liver, kidney and small bowel microsomes

Marschall, H., MATERN, H., Egestad, B., Matern, S., & Sjövall, S. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90041-5 · Cited by 36

Influence of microbial bile salt desulfation upon the fecal excretion of bile salts in gnotobiotic rats

Eyssen, H., Eldere, J. V., Parmentier, G. G., Huijghebaert, S., & Mertens, J. (1985) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(85)90176-1 · Cited by 36

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)

Lionarons, D. A., Boyer, J. L., & Cai, S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m025726 · Cited by 36

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug–drug interactions

Grandvuinet, A. S., Vestergaard, H. T., Rapin, N., & Steffansen, B. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01505.x · Cited by 34

Neurosteroid transport by the organic solute transporter OSTα–OSTβ

Fang, F., Christian, W. V., Gorman, S. G., Cui, M., Huang, J., Tieu, K., & Ballatori, N. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06920.x · Cited by 33

Glucuronidation of bile acids in human liver, intestine and kidney

Parquet, M., Pessah, M., SACQUET, E., Salvat, C., Raizman, A., & Infante, R. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)81020-6 · Cited by 33

Identification of a novel conjugate in human urine: bile acid acyl galactosides

Goto, T., Shibata, A. C. E., Sasaki, D., Suzuki, N., Hishinuma, T., Kakiyama, G., Iida, T., Mano, N., & Goto, J. (2005) · Steroids · doi:10.1016/j.steroids.2004.12.006 · Cited by 33

Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE−/− mice

Lan, T., Haywood, J., & Dawson, P. A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.05.017 · Cited by 32

Positions of conjugation of bile acids with glucose and N-acetylglucosamine in vitro.

Marschall, H., Griffiths, W. J., Zhang, J., Wietholtz, H., MATERN, H., Matern, S., & Sjövall, J. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41158-7 · Cited by 32

Fecal bile acid metabolic pattern after administration of different types of bread

Korpela, J. T., Korpela, R., & Adlercreutz, H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91511-2 · Cited by 31

Specificity of bile salt sulfatase activity in man, mouse and rat intestinal microflora

Huijghebaert, S., Parmentier, G. G., & Eyssen, H. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90404-7 · Cited by 30

Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity

Kunne, C., Acco, A., Hohenester, S. D., Duijst, S., de Waart, D. R., Zamanbin, A., & Elferink, R. P. J. O. (2012) · Hepatology · doi:10.1002/hep.26133 · Cited by 30

Evidence for an anion exchange mechanism for uptake of conjugated bile acid from the rat jejunum

Amelsberg, A., Jochims, C., Richter, C. P., Nitsche, R., & Fölsch, U. R. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.3.g737 · Cited by 30

Polydeoxycholate in human and hamster feces: a major product of cholate metabolism.

Benson, G. M., Haskins, N. J., Eckers, C., Moore, P. J., Reid, D. G., Mitchell, R. C., Waghmare, S. V., & Suckling, K. E. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35353-0 · Cited by 28

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

Yu, X. X., Watts, L. M., Manchem, V. P., Chakravarty, K., Monia, B. P., McCaleb, M. L., & Bhanot, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066923 · Cited by 28

Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans

Olivier-Mason, A., Wojtyniak, M., Bowie, R. V., Nechipurenko, I. V., Blacque, O. E., & Sengupta, P. (2013) · Development · doi:10.1242/dev.086249 · Cited by 26

Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism

Zhang, Y., Csanaky, I. L., Selwyn, F. P., Lehman‐McKeeman, L. D., & Klaassen, C. D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.020 · Cited by 24

Identification of the bile acid binding proteins in human serum by photoaffinity labeling

Kramer, W. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00075-n · Cited by 24

Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency

Gälman, C., Östlund‐Lindqvist, A., Björquist, A., Schreyer, S. A., Svensson, L., Angelin, B., & Rudling, M. J. (2002) · The FASEB Journal · doi:10.1096/fj.02-0341fje · Cited by 24

Efflux of bile acids in Lactobacillus reuteri is mediated by ATP

Bustos, A. Y., Raya, R. R., de Valdez, G. F., & Taranto, M. P. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0696-3 · Cited by 23

Lack of evidence for vesicle trafficking of fluorescent bile salts in rat hepatocyte couplets

El-Seaidy, A. Z., Mills, C. O., Elias, E., & Crawford, J. M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.2.g298 · Cited by 22

Metabolism of deoxycholic acid in bile fistula patients

Hanson, R. F., & Williams, G. C. (1971) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39456-6 · Cited by 22

Formation of bile acid glucosides and dolichyl phosphoglucose by microsomal glucosyltransferases in liver, kidney and intestine of man

MATERN, H., & Matern, S. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90163-9 · Cited by 21

Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man†

Hofmann, A. F. (2007) · Hepatology · doi:10.1002/hep.21576 · Cited by 21

The relative ligand binding preference of the murine ileal lipid binding protein

Labonté, E. D., Li, Q., Kay, C. M., & Agellon, L. B. (2003) · Protein Expression and Purification · doi:10.1016/s1046-5928(02)00561-2 · Cited by 21

Enzymatic Sulphation of Bile Salts in Man

Lööf, L., & Wengle, B. (1979) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527909181383 · Cited by 21

In Vivo Performance of a Novel Fluorinated Magnetic Resonance Imaging Agent for Functional Analysis of Bile Acid Transport

Vivian, D., Cheng, K., Khurana, S., Xu, S., Kriel, E. H., Dawson, P. A., Raufman, J., & Polli, J. E. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400740c · Cited by 21

Microbial Biotransformations of Bile Acids as Detected by Electrospray Mass Spectrometry

Hagey, L. R., & Krasowski, M. D. (2013) · Advances in Nutrition · doi:10.3945/an.112.003061 · Cited by 20

Differential intestinal deconjugation of taurine and glycine bile acid N-acyl amidates in rats

Zhang, R., Barnes, S., & Diasio, R. B. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.262.2.g351 · Cited by 20

CbsT2 from Lactobacillus johnsonii 100-100 Is a Transport Protein of the Major Facilitator Superfamily That Facilitates Bile Acid Antiport

Elkins, C. A., & Savage, D. C. (2003) · Microbial Physiology · doi:10.1159/000076738 · Cited by 16

Ostα−/−mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity

Wheeler, S. G., Hammond, C. L., Jornayvaz, F. R., Samuel, V. T., Shulman, G. I., Soroka, C. J., Boyer, J. L., Hinkle, P. M., & Ballatori, N. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00368.2013 · Cited by 16

Bile acid ethyl esters

Harris, W. S., Marai, L., Myher, J. J., & Subbiah, M. T. R. (1977) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)80965-6 · Cited by 15

Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα

Fang, C., Filipp, F. V., & Smith, J. W. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m021733 · Cited by 15

Human intestinal sulphation of lithocholate: A new site for bile acid metabolism

Dew, M. J., Hawker, P. C., Nutter, S., & Allan, R. N. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90199-x · Cited by 14

Sulfated bile acids in serum, bile, and urine of cirrhotic patients before and after portacaval anastomosis

Capocaccia, L., Attili, A. F., Cantàfora, A., Bracci, F., Paciscopi, L., Puoti, C., Pi�che, U., & Angelico, M. (1981) · Digestive Diseases and Sciences · doi:10.1007/bf01308099 · Cited by 14

Sulphation of lithocholic acid in the colon-carcinoma cell line CaCo-2

Halvorsen, B. L., Kase, B. F., Prydz, K., GARAGOZLIAN, S., Andresen, M. S., & Kolset, S. O. (1999) · Biochemical Journal · doi:10.1042/bj3430533 · Cited by 13

A Cholecystohepatic Shunt Pathway: Does the Gallbladder Protect the Liver?

Boyer, J. L., & Soroka, C. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.036 · Cited by 12

Identification of Novel Nonsteroidal Compounds as Substrates or Inhibitors of hASBT

Kolhatkar, V., Diao, L., Acharya, C., MacKerell, A. D., & Polli, J. E. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22728 · Cited by 10

Hepatic uptake and intestinal absorption of bile acids in the rabbit

Aldini, R., Roda, A., Montagnani, M., Polimeni, C., Lenzi, P., Cerré, C., Galletti, G., & Roda, E. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb01062.x · Cited by 10

Sulphated bile acids in duodenal juice of healthy infants and children compared with sulphated bile acids in paediatric patients with various gastroenterological diseases.

Niessen, K. H., Teufel, M., & Brügmann, G. (1984) · Gut · doi:10.1136/gut.25.1.26 · Cited by 6

Difference in enzymatic sulfation of bile acids between the mouse and rat.

Takahashi, A., Tanida, N., Kang, K., Umibe, S., Kawaura, A., Furukawa, K., Hikasa, Y., Satomi, M., & Shimoyama, T. (1990) · PubMed · Cited by 4

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., Andrews, E., Ajami, N. J., Bonham, K. S., Brislawn, C. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1237-9 · Cited by 3,143

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D., & Patterson, A. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00805-x · Cited by 1,214

Consequences of bile salt biotransformations by intestinal bacteria

Ridlon, J. M., Harris, S. C., Bhowmik, S., Kang, D.-J., & Hylemon, P. B. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1127483 · Cited by 1,128

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Ferrebee, C. B., & Dawson, P. A. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.001 · Cited by 131

Advances in research on the effects of bile acids and their receptors on intestinal function

Cheng, Y., Zhang, L., Zhang, M., & Yu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1821418 · Cited by 6

Meetings and Courses

Lei, S.-Y. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60407-6

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L., & Patterson, A. D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108238 · Cited by 529

A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling

Shulpekova, Y. O., Shirokova, E. N., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., et al. (2022) · Molecules · doi:10.3390/molecules27061983 · Cited by 77