Intestinal transport and metabolism of bile acids

Diet rapidly and reproducibly alters the human gut microbiome

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Host-gut microbiota metabolic interactions

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

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The interaction between bacteria and bile

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The microbiome and cancer

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Bile Acid Metabolism and Signaling

Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662

Targeting bile‐acid signalling for metabolic diseases

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Bile acids and the gut microbiome

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Pleiotropic Roles of Bile Acids in Metabolism

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

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Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

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Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

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Bile acid signaling in metabolic disease and drug therapy

Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

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Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

Hofmann, A. F., & Hagey, L. R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7568-6 · Cited by 873

Microbes, Microbiota, and Colon Cancer

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Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.003 · Cited by 797

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, G. A., Ismair, M. G., Stieger, B., Landmann, L., Huber, R., Pizzagalli, F., Fattinger, K. E., Meier, P. J., & Hagenbuch, B. (2001) · Gastroenterology · doi:10.1053/gast.2001.21176 · Cited by 718

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

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Bile acid receptors as targets for drug development

Schaap, F. G., Trauner, M., & Jansen, P. L. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.151 · Cited by 696

Bile acids as regulatory molecules

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Bile acid transporters

Dawson, P. A., Lan, T., & Rao, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900012-jlr200 · Cited by 683

The MRP family of drug efflux pumps

Kruh, G. D., & Belinsky, M. G. (2003) · Oncogene · doi:10.1038/sj.onc.1206953 · Cited by 615

Role of Bile Acid Malabsorption in Pathogenesis of Diarrhea and Steatorrhea in Patients with Ileal Resection

Hofmann, A. F., & Poley, J. R. (1972) · Gastroenterology · doi:10.1016/s0016-5085(72)80109-4 · Cited by 549

Bile resistance mechanisms in Lactobacillus and Bifidobacterium

Ruiz, L., Margolles, A., & Sánchez, B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00396 · Cited by 548

Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings

Hernell, O., Staggers, J. E., & Carey, M. C. (1990) · Biochemistry · doi:10.1021/bi00460a012 · Cited by 500

The human fatty acid-binding protein family: Evolutionary divergences and functions

Smathers, R. L., & Petersen, D. R. (2011) · Human Genomics · doi:10.1186/1479-7364-5-3-170 · Cited by 493

Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride.

Hofmann, A. F., & Poley, J. R. (1972) · PubMed · Cited by 477

Active efflux of bile salts by Escherichia coli

Thanassi, D. G., Cheng, L. W., & Nikaido, H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.8.2512-2518.1997 · Cited by 471

Beyond intestinal soap—bile acids in metabolic control

Kuipers, F., Bloks, V. W., & Groen, A. K. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.60 · Cited by 462

The role of the gut microbiota in nonalcoholic fatty liver disease

Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

Hofmann, A. F., & Borgström, B. (1964) · Journal of Clinical Investigation · doi:10.1172/jci104909 · Cited by 442

Bile salts of vertebrates: structural variation and possible evolutionary significance

Hofmann, A. F., Hagey, L. R., & Krasowski, M. D. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r000042 · Cited by 427

Role of the Microbiome in Energy Regulation and Metabolism

Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.008 · Cited by 421

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

Halilbasic, E., Claudel, T., & Trauner, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 415

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

Alnouti, Y. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfn268 · Cited by 404

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).

Oelkers, P. M., Kirby, L. C., Heubi, J. E., & Dawson, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119355 · Cited by 379

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann, A. F., & Hagey, L. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r049437 · Cited by 365

Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria

Kurdi, P., Kawanishi, K., Mizutani, K., & Yokota, A. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.5.1979-1986.2006 · Cited by 364

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

Nozawa, T., Imai, K., Nezu, J., Tsuji, A., & Tamai, I. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060194 · Cited by 351

Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice

Dawson, P. A., Haywood, J., Craddock, A. L., Wilson, M. D., Tietjen, M., Kluckman, K. D., Maeda, N., & Parks, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306370200 · Cited by 337

Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship

Ridlon, J. M., Alves, J. M., Hylemon, P. B., & Bajaj, J. S. (2013) · Gut Microbes · doi:10.4161/gmic.25723 · Cited by 336

OSTα‐OSTβ

Ballatori, N., Christian, W. V., Lee, J., Dawson, P. A., Soroka, C. J., Boyer, J. L., Madejczyk, M. S., & Li, N. (2005) · Hepatology · doi:10.1002/hep.20961 · Cited by 336

Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis

Wang, R., Salem, M., Yousef, I. M., Tuchweber, B., Lam, P., Childs, S. J., Helgason, C. D., Ackerley, C. A., Phillips, M. J., & Ling, V. W. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2011 · Cited by 333

Inhibiting the Initiation of Clostridium difficile Spore Germination using Analogs of Chenodeoxycholic Acid, a Bile Acid

Sorg, J. A., & Sonenshein, A. L. (2010) · Journal of Bacteriology · doi:10.1128/jb.00610-10 · Cited by 332

Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes

Studer, E. J., Zhou, X., Zhao, R., Wang, Y., Takabe, K., Nagahashi, M., Pandak, W. M., Dent, P., Spiegel, S., Shi, R., et al. (2011) · Hepatology · doi:10.1002/hep.24681 · Cited by 327

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321

Movement of fatty acids, fatty acid analogs, and bile acids across phospholipid bilayers

Kamp, F., & Hamilton, J. A. (1993) · Biochemistry · doi:10.1021/bi00092a017 · Cited by 315

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

Fouts, D. E., Torralba, M., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.019 · Cited by 311

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

Sato, H., Macchiarulo, A., Thomas, C., Gioiello, A., Une, M., Hofmann, A. F., Saladin, R., Schoonjans, K., Pellicciari, R., & Auwerx, J. H. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7015864 · Cited by 311

Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter

Craddock, A. L., Love, M. W., Daniel, R. W., Kirby, L. C., Walters, H. C., Wong, M. H., & Dawson, P. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.1.g157 · Cited by 308

Significance of bile salt hydrolytic activities of lactobacilli

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Mechanisms for the intestinal absorption of bile acids

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Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat

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Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

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Effect of bile salts on the DNA and membrane integrity of enteric bacteria

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Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings

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Bile acids are nutrient signaling hormones

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Screening of Lactic Acid Bacteria for Bile Salt Hydrolase Activity

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Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

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Detoxification of Lithocholic Acid, A Toxic Bile Acid: Relevance to Drug Hepatotoxicity

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Human cecal bile acids: concentration and spectrum

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Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

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Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents

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Active and Passive Bile Acid Absorption in Man. PERFUSION STUDIES OF THE ILEUM AND JEJUNUM

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How bile acids confer gut mucosal protection against bacteria

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Therapeutic Modulation of Microbiota-Host Metabolic Interactions

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Transport of amphipathic anions by human multidrug resistance protein 3.

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Molecular mechanisms underlying bile acid‐stimulated glucagon‐like peptide‐1 secretion

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The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis

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Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition

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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

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Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice

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Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

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Bile acids: analysis in biological fluids and tissues

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Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

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Is bile acid a determinant of the gut microbiota on a high-fat diet?

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Tissue Distribution and Ontogeny of Sulfotransferase Enzymes in Mice

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Bile Acids Activate YAP to Promote Liver Carcinogenesis

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The solute carrier family 10 (SLC10): Beyond bile acid transport

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Organic Anion-Transporting Polypeptides

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Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.

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Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

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Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides

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TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

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Colonic inflammation and secondary bile acids in alcoholic cirrhosis

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Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice

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Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

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Identification of the Bile Acid-binding Site of the Ileal Lipid-binding Protein by Photoaffinity Labeling, Matrix-assisted Laser Desorption Ionization-Mass Spectrometry, and NMR Structure

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Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

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The ABC-Type Multidrug Resistance Transporter LmrCD Is Responsible for an Extrusion-Based Mechanism of Bile Acid Resistance in Lactococcus lactis

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Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism

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Multicomponent analysis of bile acids in faeces by anion exchange and capillary column gas-liquid chromatography: Application in oxytetracycline treated subjects

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Metabolism of iso-bile acids in the rat.

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The X-Ray Structure of Zebrafish (Danio rerio) Ileal Bile Acid-Binding Protein Reveals the Presence of Binding Sites on the Surface of the Protein Molecule

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Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis

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Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion

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Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

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Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

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Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

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Consequences of bile salt biotransformations by intestinal bacteria

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Regulation of Intestinal Barrier Function by Microbial Metabolites

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Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

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Advances in research on the effects of bile acids and their receptors on intestinal function

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Meetings and Courses

Lei, S.-Y. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60407-6

Bile acid metabolism and signaling, the microbiota, and metabolic disease

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A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling

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