Cited by 620Drug Transport and Resistance MechanismsGut microbiota and healthCholesterol and Lipid Metabolism

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Intestinal transport and metabolism of bile acids

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Dawson, Paul A., Karpen, Saul J.·2015·Journal of Lipid Research

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Abstract

In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling.

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Authors: Dawson, P. A., & Karpen, S. J.
Affiliations: Emory University (US)
Corresponding author: Dawson, Paul A.
ORCID: Dawson, Paul A.
Karpen, Saul J.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2015-06
Volume: 56
Issue: 6
Pages: 1085-1099
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r054114
PMC: PMC4442867
OpenAlex: W2316224242
Cited by: 598
References: 249
Citations by year: 2026: 59 · 2025: 80 · 2024: 72 · 2023: 51 · 2022: 65 · 2021: 64 · 2020: 59 · 2019: 43 · 2018: 43 · 2017: 31 · 2016: 20 · 2015: 10
FWCI: 2.35
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 1959 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056239, R29DK047987, DK056239, DK-047987, R01DK047987)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: bile acids, bile acid metabolism, enterohepatic circulation, gut microbiota, bile acid signaling, nuclear receptors, G protein-coupled receptors, intestinal homeostasis, host-microbe interactions
MeSH terms: Animals, Bile Acids and Salts, Enterohepatic Circulation, Homeostasis, Intestinal Mucosa, Signal Transduction, Hepatocytes, Receptors, G-Protein-Coupled, Lipid Metabolism, Microbiota

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Intestinal transport and metabolism of bile acids

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