The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
Open accessAbstract
The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive liver disease, termed nonalcoholic steatohepatitis, which is characterized by hepatocellular apoptosis and innate immune system-mediated inflammation. These responses are orchestrated by signaling pathways that can be activated by lipids, directly or indirectly. In this review, we discuss palmitate- and lysophosphatidylcholine (LPC)-induced upregulation of p53-upregulated modulator of apoptosis and cell-surface expression of the death receptor TNF-related apoptosis-inducing ligand receptor 2. Next, we review the activation of stress-induced kinases, mixed lineage kinase 3, and c-Jun N-terminal kinase, and the activation of endoplasmic reticulum stress response and its downstream proapoptotic effector, CAAT/enhancer binding homologous protein, by palmitate and LPC. Moreover, the activation of these stress signaling pathways is linked to the release of proinflammatory, proangiogenic, and profibrotic extracellular vesicles by stressed hepatocytes. This review discusses the signaling pathways induced by lethal and sublethal lipid overload that contribute to the pathogenesis of NAFLD.
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“In both scenarios failed or inadequate metabolic adaptation to substrate overload results in sublethal cell stress or even cell death with release of mediators and extracellular vesicles driving inflammation and fibrosis15–17”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [17]
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Cites
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Research works printed but not linked: 1
- Ibrahim, 2016, Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes, Hepatology., 63:, 731, 10.1002/hep.28252 · DOI · Paper page
Cited by
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Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
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Lipotoxicity and the gut-liver axis in NASH pathogenesis
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Molecular pathways of nonalcoholic fatty liver disease development and progression
Bessone, F., Razori, M. V., & Roma, M. G. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2947-0 · Cited by 664
Metadata
- Authors
- Hirsova, P., Ibrabim, S. H., Gores, G. J., & Malhi, H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gores, Gregory J.
- Malhi, Harmeet
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 57
- Issue
- 10
- Pages
- 1758-1770
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC5036373
- OpenAlex
- W2321179708
- Cited by
- 270
- References
- 141
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 22 · 2023: 28 · 2022: 35 · 2021: 36 · 2020: 35 · 2019: 23 · 2018: 28 · 2017: 16 · 2016: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-01-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Office of Extramural Research, National Institutes of Health (DK97178, DK41876, KL2TR000136-09)
- American Liver Foundation
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, hepatocyte apoptosis, lipid overload, palmitate, lysophosphatidylcholine, TRAIL receptor 2, MLK3, c-Jun N-terminal kinase, endoplasmic reticulum stress, CHOP, extracellular vesicles, liver inflammation, liver fibrosis, obesity
- MeSH terms
- Mitogen-Activated Protein Kinase Kinase Kinase 11, Animals, Humans, Lysophosphatidylcholines, Palmitates, Stress, Physiological, Up-Regulation, Tumor Suppressor Protein p53, MAP Kinase Kinase Kinases, MAP Kinase Signaling System, CCAAT-Enhancer-Binding Proteins, Hepatocytes, TNF Receptor-Associated Factor 2, JNK Mitogen-Activated Protein Kinases, Non-alcoholic Fatty Liver Disease
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