Biomarkers in nutritional epidemiology: applications, needs and new horizons

Jenab, Mazda; Slimani, Nadia; Bictash, Magda; Ferrari, Pietro; Bingham, Sheila A.

doi:10.1007/s00439-009-0662-5

Cited by 448Nutrition, Genetics, and DiseaseNutritional Studies and DietMetabolomics and Mass Spectrometry Studies

Biomarkers in nutritional epidemiology: applications, needs and new horizons

Jenab, Mazda, Slimani, Nadia, Bictash, Magda, Ferrari, Pietro, Bingham, Sheila A.·2009·Human Genetics

DOI 10.1007/s00439-009-0662-5

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Abstract

Modern epidemiology suggests a potential interactive association between diet, lifestyle, genetics and the risk of many chronic diseases. As such, many epidemiologic studies attempt to consider assessment of dietary intake alongside genetic measures and other variables of interest. However, given the multi-factorial complexities of dietary exposures, all dietary intake assessment methods are associated with measurement errors which affect dietary estimates and may obscure disease risk associations. For this reason, dietary biomarkers measured in biological specimens are being increasingly used as additional or substitute estimates of dietary intake and nutrient status. Genetic variation may influence dietary intake and nutrient metabolism and may affect the utility of a dietary biomarker to properly reflect dietary exposures. Although there are many functional dietary biomarkers that, if utilized appropriately, can be very informative, a better understanding of the interactions between diet and genes as potentially determining factors in the validity, application and interpretation of dietary biomarkers is necessary. It is the aim of this review to highlight how some important biomarkers are being applied in nutrition epidemiology and to address some associated questions and limitations. This review also emphasizes the need to identify new dietary biomarkers and highlights the emerging field of nutritional metabonomics as an analytical method to assess metabolic profiles as measures of dietary exposures and indicators of dietary patterns, dietary changes or effectiveness of dietary interventions. The review will also touch upon new statistical methodologies for the combination of dietary questionnaire and biomarker data for disease risk assessment. It is clear that dietary biomarkers require much further research in order to be better applied and interpreted. Future priorities should be to integrate high quality dietary intake information, measurements of dietary biomarkers, metabolic profiles of specific dietary patterns, genetics and novel statistical methodology in order to provide important new insights into gene-diet-lifestyle-disease risk associations.

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In clinical practice, biochemical procedures are used to diagnose nutritional deficiencies, evaluate the response to dietary interventions, and monitor health status in individuals with chronic or acute conditions.
“In clinical practice, these procedures are used to diagnose nutritional deficiencies, evaluate the response to dietary interventions, and monitor health status in individuals with chronic or acute conditions.”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [26]
Dietary biomarkers have been used as more objective measures of dietary exposure in nutritional epidemiology.
“The application of dietary biomarkers as more objective measures of dietary exposure in nutritional epidemiology has been particularly significant (13).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [13]

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Authors: Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A.
Affiliations: Centre international de recherche sur le cancer (FR)
Imperial College London (GB)
European Food Safety Authority (IT)
University of Cambridge (GB)
Corresponding author: Jenab, Mazda
ORCID: Jenab, Mazda
Slimani, Nadia
Bictash, Magda
Ferrari, Pietro
Venue: Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-04-09
Volume: 125
Issue: 5-6
Pages: 507-525
ISSN: 0018-7348 (ISSN-L)
0340-6717
1432-1203
DOI: 10.1007/s00439-009-0662-5
OpenAlex: W2032872692
Cited by: 448
References: 186
Citations by year: 2026: 12 · 2025: 15 · 2024: 13 · 2023: 25 · 2022: 12 · 2021: 31 · 2020: 35 · 2019: 31 · 2018: 40 · 2017: 34 · 2016: 27 · 2015: 35 · 2014: 25 · 2013: 25 · 2012: 33
FWCI: 2.67
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Human Genetics (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: dietary biomarkers, nutritional epidemiology, dietary assessment, measurement error, genetic variation, gene-diet interaction, metabolic profile, dietary habits, dietary intervention, dietary questionnaire, disease risk assessment, nutrient status
MeSH terms: Diet, Humans, Nutritional Physiological Phenomena, Biomarkers, Molecular Epidemiology, Risk Assessment, Metabolomics, Metabolome

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Biomarkers in nutritional epidemiology: applications, needs and new horizons

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