The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The metabolism and anti-atherogenic properties of HDL
Open accessAbstract
Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.
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“Lowered levels of lipoprotein sub-fractions HDL2 and HDL3 are considered to increase CVD risk, although HDL3 may be less protective in the presence of MetS [15].”
Citations
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Metadata
- Authors
- Rye, K.-A., Bursill, C. A., Lambert, G., Tabet, F., & Barter, P. J.
- Affiliations
- The University of Sydney (AU)
- The Heart Research Institute (AU)
- Corresponding author
- Rye, Kerry-Anne
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S195-S200
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC2674714
- OpenAlex
- W1967702791
- Cited by
- 331
- References
- 51
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 12 · 2023: 17 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 21 · 2017: 13 · 2016: 9 · 2015: 27 · 2014: 21 · 2013: 48 · 2012: 20
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- HDL metabolism, HDL subpopulations, atherosclerosis, cardioprotection, cardiovascular risk, HDL function, HDL-targeted therapy
- MeSH terms
- Animals, Antioxidants, Humans, Inflammation, Cholesterol, HDL, Genetic Heterogeneity, Atherosclerosis
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