Cited by 331Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

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The metabolism and anti-atherogenic properties of HDL

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Rye, Kerry-Anne, Bursill, Christina A., Lambert, Gilles, Tabet, Fatiha, Barter, Philip J.·2009·Journal of Lipid Research

DOI 10.1194/jlr.r800034-jlr200PMC PMC2674714

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Abstract

Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.

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Authors: Rye, K.-A., Bursill, C. A., Lambert, G., Tabet, F., & Barter, P. J.
Affiliations: The University of Sydney (AU)
The Heart Research Institute (AU)
Corresponding author: Rye, Kerry-Anne
ORCID: Bursill, Christina A.
Lambert, Gilles
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2009-04
Volume: 50
Pages: S195-S200
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r800034-jlr200
PMC: PMC2674714
OpenAlex: W1967702791
Cited by: 331
References: 51
Citations by year: 2026: 13 · 2025: 14 · 2024: 12 · 2023: 17 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 21 · 2017: 13 · 2016: 9 · 2015: 27 · 2014: 21 · 2013: 48 · 2012: 20
FWCI: 2.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4185 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: HDL metabolism, HDL subpopulations, atherosclerosis, cardioprotection, cardiovascular risk, HDL function, HDL-targeted therapy
MeSH terms: Animals, Antioxidants, Humans, Inflammation, Cholesterol, HDL, Genetic Heterogeneity, Atherosclerosis

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The metabolism and anti-atherogenic properties of HDL

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