Nutraceutical Properties of Chestnut Flours: Beneficial Effects on Skeletal Muscle Atrophy
Open accessAbstract
Plants contain a wide range of non-nutritive phytochemicals, many of which have protective or preventive properties for human diseases. The aim of the present work has been to investigate the nutraceutical properties of sweet chestnut flour extracts obtained from fruits collected from 7 geographic areas of Tuscany (Italy), and their ability in modulating skeletal muscle atrophy. We found that the cultivars from different geographic areas are characterized by the composition and quantity of various nutrients and specific bioactive components, such as tocopherols, polyphenols and sphingolipids. The nutraceutical properties of chestnut sweet flours have been evaluated in C2C12 myotubes induced to atrophy by serum deprivation or dexamethasone. We found that the pretreatment with both total extracts of tocopherols and sphingolipids is able to counterbalance cell atrophy, reducing the decrease in myotube size and myonuclei number, and attenuating protein degradation and the increase in expression of MAFbx/atrogin-1 (a muscle-specific atrophy marker). By contrast, polyphenol extracts were not able to prevent atrophy. Since we also found that γ-tocopherol is the major form of tocopherol in sweet flour and its content differs depending on the procedure of sweet flour preparation, the mechanisms by which γ-tocopherol as well as sphingolipids affect skeletal muscle cell atrophy have been also investigated. This is the first evidence that chestnut sweet flour is a natural source of specific bioactive components with a relevant role in the prevention of cell degeneration and maintenance of skeletal muscle mass, opening important implications in designing appropriate nutritional therapeutic approaches to skeletal muscle atrophy.
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Chestnut flours extracts inhibit the expression of MAFbx in C2C12 myotubes muscle atrophy induced by dexamethasone.
“For example, chestnut flours extracts, characterized by the composition and quantity of various nutrients and specific bioactive components, such as tocopherols, polyphenols, and sphingolipids, inhibit the expression of MAFbx in C2C12 myotubes muscle atrophy induced by dexamethasone [105].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [105]
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- Authors
- Frati, A., Landi, D., Marinelli, C., Gianni, G., Fontana, L., Migliorini, M., Pierucci, F., Garcia-Gil, M., & Meacci, E.
- Affiliations
- University of Florence (IT)
- Camera di Commercio di Firenze (IT)
- Corresponding author
- Meacci, Elisabetta
- Venue
- Food Funct.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014-09-03
- Volume
- 5
- Issue
- 11
- Pages
- 2870-2882
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2141914619
- Cited by
- 23
- References
- 47
- Citations by year
- 2025: 4 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, other-oa)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Regione Toscana
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- chestnut flour, nutraceuticals, skeletal muscle atrophy, gamma-tocopherol, tocopherols, sphingolipids, polyphenols, atrogin-1/MAFbx, myotube atrophy, dexamethasone-induced atrophy, serum deprivation, C2C12 myotubes, bioactive compounds, chestnut cultivars, Tuscany
- MeSH terms
- Animals, Cell Line, Dexamethasone, Flour, Italy, Muscular Atrophy, Plant Extracts, Sphingolipids, Muscle, Skeletal, Muscle Fibers, Skeletal, Dietary Supplements, Tocopherols, Fagaceae, Mice, Proteolysis, Polyphenols
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