Accumulation of Somatic Mutation in Mitochondrial DNA and Atherosclerosis in Diabetic Patients

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

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Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

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Oxidative damage to DNA in diabetes mellitus

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A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

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A point mutation in the mitochondrial tRNALeu(UUR) gene in melas (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes)

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Polymorphism of the NADH/NADPH Oxidase p22 phox Gene in Patients With Coronary Artery Disease

Inoue, N., Kawashima, S., Kanazawa, K., Yamada, S., Akita, H., & Yokoyama, M. (1998) · Circulation · doi:10.1161/01.cir.97.2.135 · Cited by 238 · see citing works

Differential Activation of Mitogen-Activated Protein Kinases in Smooth Muscle Cells by Angiotensin II

Viedt, C., Soto, U., Krieger‐Brauer, H. I., Fei, J., Elsing, C., Kübler, W., & Kreuzer, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.940 · Cited by 216 · see citing works

Oxidative DNA damage in diabetes mellitus: its association with diabetic complications

Hinokio, Y., Suzuki, S., Hirai, M., Chiba, M., Hirai, A. M., & Toyota, T. (1999) · Diabetologia · doi:10.1007/s001250051258 · Cited by 209 · see citing works

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases

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Oxidative damage to mitochondrial DNA and its relationship to diabetic complications

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Human aging is associated with stochastic somatic mutations of mitochondrial DNA

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Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.

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Human Aging is Associated with Various Point Mutations in tRNA Genes of Mitochondrial DNA

Münscher, C., Müller‐Höcker, J., & Kadenbach, B. (1993) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1993.374.7-12.1099 · Cited by 96 · see citing works

Effect of Polymorphism of Apolipoprotein E and Angiotensin-Converting Enzyme Genes on Arterial Wall Thickness

Satō, K., Nishizawà, Y., Hosoi, M., Kawagishi, T., Maekawa, K., Shoji, T., Okuno, Y., & Morii, H. (1997) · Diabetes · doi:10.2337/diab.46.4.682 · Cited by 89 · see citing works

Aging and high concentrations of glucose potentiate injury to mitochondrial DNA

Fukagawa, N. K., Li, M., Liang, P., Russell, J. C., Sobel, B. E., & Absher, P. M. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00189-6 · Cited by 60 · see citing works

Increased Prevalence of Mitochondrial DNA Deletions in Skeletal Muscle of Older Individuals With Impaired Glucose Tolerance: Possible Marker of Glycemic Stress

Liang, P., HUGHES, V. A., & Fukagawa, N. K. (1997) · Diabetes · doi:10.2337/diab.46.5.920 · Cited by 58 · see citing works

Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients

Nomiyama, T., Tanaka, Y., Hattori, N., Nishimaki, K., Nagasaka, K., Kawamori, R., & Ohta, S. (2002) · Diabetologia · doi:10.1007/s00125-002-0893-7 · Cited by 55 · see citing works

Blockade of Angiotensin II Type 1 Receptor and Not of Endothelin Receptor Prevents Hypertension and Cardiovascular Disease in Transgenic (mREN2)27 Rats via Adrenocortical Steroid–Independent Mechanisms

Rossi, G. P., Sacchetto, A., Rizzoni, D., Bova, S., Porteri, E., Mazzocchi, G., Belloni, A. S., Bahçelioğlu, M., Nussdorfer, G. G., & Pessina, A. C. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.949 · Cited by 53 · see citing works

Asymptomatic hyperglycaemia and early atherosclerotic changes

Kawamori, R. (1998) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(98)00041-2 · Cited by 43 · see citing works

Combined genotypes of ACE and NADPH oxidase p22phox associated with somatic mutation of mtDNA and carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus

Piao, L., Tanaka, Y., Nomiyama, T., Nakajima, K., Ogihara, T., Miwa, S., Urabe, T., Watada, H., & Kawamori, R. (2002) · Current Therapeutic Research · doi:10.1016/s0011-393x(02)80089-3 · Cited by 6 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

Mitochondria, endothelial cell function, and vascular diseases

Tang, X., Luo, Y., Chen, H., & Liu, D. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00175 · Cited by 345 · see citing works

Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation

Murphy, R., Turnbull, D. M., Walker, M., & Hattersley, A. T. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02359.x · Cited by 290 · see citing works

Genetic, pathogenetic, and phenotypic implications of the mitochondrial A3243G tRNALeu(UUR) mutation

Finsterer, J. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00836.x · Cited by 125 · see citing works

Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease

Fetterman, J. L., Holbrook, M., Westbrook, D. G., Brown, J. A., Feeley, K. P., Bretón‐Romero, R., Linder, E. A., Berk, B. D., Weisbrod, R. M., Widlansky, M. E., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0372-y · Cited by 106 · see citing works

Genetic determinants of carotid ultrasound traits

Pollex, R. L., & Hegele, R. A. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0075-z · Cited by 55 · see citing works

Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria

Silzer, T. K., & Phillips, N. R. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.04.004 · Cited by 53 · see citing works

Quantitative Assessment of Heteroplasmy of Mitochondrial Genome: Perspectives in Diagnostics and Methodological Pitfalls

Sobenin, I. A., Mitrofanov, K. Y., Викторович, Ж. А., Sazonova, M. A., Postnov, A. Y., Ревин, В. В., Bobryshev, Y. V., & Orekhov, A. N. (2014) · BioMed Research International · doi:10.1155/2014/292017 · Cited by 52 · see citing works

The alterations of mitochondrial DNA in coronary heart disease

Hu, H., Lin, Y., Xu, X., Lin, S., Chen, X., & Wang, S. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104412 · Cited by 51 · see citing works

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury

Terawaki, Y., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Takahashi, H., Tanaka, T., Murase, K., Nagaishi, R., Tanabe, M., & Yanase, T. (2014) · Cardiovascular Diabetology · doi:10.1186/preaccept-9752811371415510 · Cited by 48 · see citing works

Role of somatic mutations in vascular disease formation

Weakley, S. M., Jiang, J. H., Kougias, P., Lin, P. H., Yao, Q. C., Brunicardi, F. C., Gibbs, R. A., & Chen, C. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.1 · Cited by 42 · see citing works

Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease

Volobueva, A. S., Grechko, A. V., Yet, S., Sobenin, I. A., & Orekhov, A. N. (2019) · Biomolecules · doi:10.3390/biom9080377 · Cited by 38 · see citing works

Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Orekhov, A. N., Nikiforov, N. G., Ivanova, E. A., & Sobenin, I. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040978 · Cited by 37 · see citing works

Chronically elevated glucose compromises myocardial mitochondrial DNA integrity by alteration of mitochondrial topoisomerase function

Medikayala, S., Piteo, B., Zhao, X., & Edwards, J. G. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00248.2010 · Cited by 36 · see citing works

Mitochondrial Aging: Focus on Mitochondrial DNA Damage in Atherosclerosis - A Mini-Review

Sobenin, I. A., Викторович, Ж. А., Sinyov, V. V., Bobryshev, Y. V., & Orekhov, A. N. (2014) · Gerontology · doi:10.1159/000368923 · Cited by 33 · see citing works

Rapid and Sensitive Real-Time Polymerase Chain Reaction Method for Detection and Quantification of 3243A>G Mitochondrial Point Mutation

Singh, R., Ellard, S., Hattersley, A. T., & Harries, L. W. (2006) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2006.050067 · Cited by 30 · see citing works

Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes

Chistiakov, D. A. (2012) · World Journal of Cardiology · doi:10.4330/wjc.v4.i5.148 · Cited by 25 · see citing works

Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes

Savu, O., Sunkari, V. G., Botusan, I. R., Grünler, J., Nikoshkov, A., & Catrina, S. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1203 · Cited by 25 · see citing works

Is atherosclerosis a mitochondrial disorder?

Finsterer (2007) · VASA · doi:10.1024/0301-1526.36.4.229 · Cited by 24 · see citing works

Association of mutations in the mitochondrial genome with the subclinical carotid atherosclerosis in women

Sazonova, M. A., Chicheva, M. M., Викторович, Ж. А., Sobenin, I. A., Bobryshev, Y. V., & Orekhov, A. N. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.04.003 · Cited by 21 · see citing works

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat

Hicks, S. D., Labinskyy, N., Piteo, B., Laurent, D., Mathew, J., Gupte, S. A., & Edwards, J. G. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2012 · Cited by 20 · see citing works

Do Mitochondrial DNA Mutations Play a Key Role in the Chronification of Sterile Inflammation? Special Focus on Atherosclerosis

Orekhov, A. N., Владимировна, Г. Е., Sukhorukov, V. N., Poznyak, A. V., & Nikiforov, N. G. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201012164330 · Cited by 9 · see citing works

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works

Carotid intima-media thickness among normoglycemia and normotension first-degree relatives of type 2 diabetes mellitus

Purnamasari, D., Abdaly, M. S., Azizi, M. S., Wijaya, I. P., & Nugroho, P. (2019) · Vascular Health and Risk Management · doi:10.2147/vhrm.s195776 · Cited by 6 · see citing works

Mitochondrial tRNALeu(UUR) gene mutation and maternally inherited diabetes mellitus in Pakistani population

Naveed, A. K., Wahid, M., & Naveed, A. (2009) · International Journal of Diabetes Mellitus · doi:10.1016/j.ijdm.2009.03.012 · Cited by 5 · see citing works

Heteroplasmic m.1624C>T mutation of the mitochondrial tRNAVal gene in a proband and his mother with repeated consciousness disturbances

Sangatsuda, Y., Nakamura, M., Tomiyasu, A., Deguchi, A., Toyota, Y., Goto, Y., Nishino, I., Ueno, S., & Sano, A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.10.002 · Cited by 5 · see citing works

Mutations of mitochondrial genome and atherosclerosis: Possible mechanistic relationship

Sobenin, I. A., Bobryshev, Y. V., Romanenko, E. B., & Orekhov, A. N. (2014)

Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients

Nomiyama, T., Tanaka, Y., Hattori, N., Nishimaki, K., Nagasaka, K., Kawamori, R., & Ohta, S. (2002) · Diabetologia · doi:10.1007/s00125-002-0893-7 · Cited by 55 · see citing works

Molecular analysis of diabetes mellitus-associated A3243G mitochondrial DNA mutation in Taiwanese cases

Liou, C., Huang, C., & Wei, Y. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00334-5 · Cited by 16 · see citing works

A3243G Mitochondrial DNA Mutation does not Play an Important Role among DM Population in Indonesia

Pranoto, A. S. (2007) · Folia Medica Indonesiana · Cited by 2 · see citing works

Combined genotypes of ACE and NADPH oxidase p22phox associated with somatic mutation of mtDNA and carotid intima-media thickness in Japanese patients with type 2 diabetes mellitus

Piao, L., Tanaka, Y., Nomiyama, T., Nakajima, K., Ogihara, T., Miwa, S., Urabe, T., Watada, H., & Kawamori, R. (2002) · Current Therapeutic Research · doi:10.1016/s0011-393x(02)80089-3 · Cited by 6 · see citing works

Study on the mtDNA tRNA~(Leu(UUR)) mutation in diabetics with onset age less than 45 years

De-mi, L. (2005) · Zhongguo tangniaobing zazhi