Cited by 53Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria

Silzer, Talisa K., Phillips, Nicole R.·2018·Mitochondrion

Abstract

Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.

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Crossref · 10.1016/j.mito.2018.04.004

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  • Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD, it is reasonable to hypothesize that lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.

    “Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD [184,185,186,187], it is reasonable to hypothesize that these lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.”

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Authors
Silzer, T. K., & Phillips, N. R.
Affiliations
University of North Texas Health Science Center (US)
Corresponding author
Phillips, Nicole R.
Venue
Mitochondrion
Publisher
Elsevier BV
Published
2018-11
Volume
43
Pages
16-24
ISSN
1567-7249 (ISSN-L)
OpenAlex
W2800292544
Cited by
53
References
114
Citations by year
2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 6
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Mitochondrion (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
type 2 diabetes, Alzheimer's disease, mitochondrial dysfunction, dementia risk, shared pathophysiology, insulin resistance, inflammation, Mexican Americans, metabolic risk, therapeutic target
MeSH terms
Alzheimer Disease, Diabetes Mellitus, Type 2, Humans, Mitochondria, Mitochondrial Diseases

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