Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria
Abstract
Type 2 diabetes is a significant risk factor for developing Alzheimer's disease later in life, and particular populations have a disproportionate risk because of the high prevalence of type 2 diabetes. There are many overlapping pathologies, and teasing out the primary root cause, if one indeed exists, is very difficult. Here, we review (1) the key facets of mitochondrial biology that are relevant to the two conditions, and (2) the role that mitochondrial dysfunction plays in the shared pathophysiology. We posit that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology.
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Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD, it is reasonable to hypothesize that lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.
“Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD [184,185,186,187], it is reasonable to hypothesize that these lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [187]
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- Authors
- Silzer, T. K., & Phillips, N. R.
- Affiliations
- University of North Texas Health Science Center (US)
- Corresponding author
- Phillips, Nicole R.
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 43
- Pages
- 16-24
- ISSN
- 1567-7249 (ISSN-L)
- OpenAlex
- W2800292544
- Cited by
- 53
- References
- 114
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 6
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mitochondrion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- type 2 diabetes, Alzheimer's disease, mitochondrial dysfunction, dementia risk, shared pathophysiology, insulin resistance, inflammation, Mexican Americans, metabolic risk, therapeutic target
- MeSH terms
- Alzheimer Disease, Diabetes Mellitus, Type 2, Humans, Mitochondria, Mitochondrial Diseases
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