The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Caspase‐12 and ER‐Stress‐Mediated Apoptosis: The Story So Far
Abstract
A bstract: The labyrinth of the endoplasmic reticulum (ER) interweaves the cytosol and connects to the nucleus, mitochondria, and the plasma membrane. In the lumen of the ER, the essential function of lipid synthesis, Ca 2+ storage, folding, and maturation of proteins take place. Therefore, the tight regulation and maintenance of ER homeostasis is vital. Disturbance of the Ca 2+ homeostasis during hypoxia, or imbalance between the demand and capacity of the protein‐folding apparatus, initiates an adaptive response of the cell, termed the unfolded protein response (UPR, ER stress response). As a result, ER‐localized chaperones are induced, protein synthesis is slowed down, and a protein degrading system is initiated. However, if the ER stress cannot be alleviated, it culminates in apoptosis. This paper reviews the newly outlined signaling pathways of the unfolded protein response and describes the central role of caspase‐12 in the initiation of cell death. The complex role of the ER and its signaling pathways provides a novel angle on apoptosis research and may offer a key to apoptosis‐associated diseases.
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1 retracted
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RetractedApoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,256
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
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Shrinkage necrosis: A distinct mode of cellular death
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Cited by
Apoptosis in cancer: from pathogenesis to treatment
Wong, R. S. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-87 · Cited by 2,836
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345
Self-citationThe Role for Endoplasmic Reticulum Stress in Diabetes Mellitus
Eizirik, D. L., Cardozo, A. K., & Cnop, M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0015 · Cited by 1,173
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086
Apoptosis (programmed cell death) and its signals - A review
Obeng, E. (2021) · Brazilian Journal of Biology · doi:10.1590/1519-6984.228437 · Cited by 513
Metadata
- Authors
- SZEGEZDI, E., FITZGERALD, U., & SAMALI, A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2003-12
- Volume
- 1010
- Issue
- 1
- Pages
- 186-194
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2152522654
- Cited by
- 506
- References
- 45
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- SZEGEZDI, E., FITZGERALD, U., & SAMALI, A. (2003). Caspase‐12 and ER‐Stress‐Mediated Apoptosis: The Story So Far. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1299.032
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
