The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
Abstract
A bstract: Numerous clinical studies demonstrate that subanesthetic doses of dissociative anesthetics, which are noncompetitive antagonists at the NMDA receptor, replicate in normal subjects the cognitive impairments, negative symptoms, and brain functional abnormalities of schizophrenia. Postmortem and genetic studies have identified several abnormalities associated with schizophrenia that would interfere with the activation of the glycine modulatory site on the NMDA receptor. Placebo‐controlled clinical trials with agents that directly or indirectly activate the glycine modulatory site consistently reduce negative symptoms and frequently improve cognition in patients with chronic schizophrenia who are receiving concurrent typical antipsychotics. Thus, there is convincing evidence that hypofunction of a subset of NMDA receptors may contribute to the symptomatic features of schizophrenia.
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Cites
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Recent advances in the phencyclidine model of schizophrenia
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The Glutamatergic Dysfunction Hypothesis for Schizophrenia
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Self-citationNMDA-dependent modulation of CA1 local circuit inhibition
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Cited by
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269
Animal models of schizophrenia
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Metadata
- Authors
- COYLE, J. T., TSAI, G., & GOFF, D.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2003-11
- Volume
- 1003
- Issue
- 1
- Pages
- 318-327
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2017267321
- Cited by
- 442
- References
- 5
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- COYLE, J. T., TSAI, G., & GOFF, D. (2003). Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1300.020
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