The Glutamatergic Dysfunction Hypothesis for Schizophrenia

Coyle, Joseph T.

doi:10.3109/10673229609017192

Cited by 568Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

Coyle, Joseph T.·1996·Harvard Review of Psychiatry

DOI 10.3109/10673229609017192

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Abstract

Schizophrenia is a syndrome, undoubtedly with multiple etiologies, that variably exhibits several features including positive and negative symptoms, cognitive deficits, onset in young adulthood, and deterioration from the previous level of function. This review will examine the growing evidence that dysfunction of corticolimbic glutamatergic neurotransmission may contribute to or account for the manifestations of schizophrenia. Glutamatergic neurons represent the primary excitatory afferent and efferent systems innervating the cortex, limbic regions, and striatum. The postsynaptic actions of glutamate are mediated by a family of glutamate-gated ion channels that permit the influx of sodium and calcium, thereby depolarizing (exciting) neurons. One of these receptors, the N-methyl-D-aspartate (NMDA) receptor, is the site of action of psychotomimetics such as phencyclidine and related anesthetics, which can reproduce in normal individuals most of the symptomatic features of schizophrenia. An endogenous antagonist at the NMDA receptor, N-acetyl-aspartyl glutamate, appears to have enhanced activity in the frontal cortex and hippocampal formation in persons with this disorder. Glutamatergic dysfunction may be particularly relevant to those forms of schizophrenia in which negative symptoms, cognitive deficits, and deterioration are prominent features. In support of this inference, clinical studies have shown that drugs that enhance NMDA-receptor function reduce negative symptoms and cognitive deficits in persons with chronic schizophrenia who are receiving neuroleptics. Thus, dysfunction of glutamatergic neurotransmission represents an important organizational focus for research on the complex manifestations of schizophrenia.

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Glial/CSPG cluster abnormalities may represent a contributing factor to dysregulated glutamatergic transmission, and more broadly to neuron/glia interactions, in major psychoses.
“Glial/CSPG cluster abnormalities may thus represent a contributing factor to dysregulated glutamatergic transmission, and more broadly to neuron/glia interactions, in major psychoses.15, 22, 105, 106”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [15]

The Pharmacological Basis of Therapeutics
(1976) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/33.4.373a · Cited by 9,216 · see citing works
Principles of neural science
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Cell Death: The Significance of Apoptosis
Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,235 · see citing works
Cloned Glutamate Receptors
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762 · see citing works
Self-citation
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,420 · see citing works
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,906 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543 · see citing works
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413 · see citing works
Bcl-2 and the regulation of programmed cell death
Reed, J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.1 · Cited by 2,287 · see citing works
Molecular pathology of schizophrenia: more than one disease process?
Crow, T. J. (1980) · BMJ · doi:10.1136/bmj.280.6207.66 · Cited by 1,863 · see citing works
Glutamate neurotoxicity in cortical cell culture
Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506 · see citing works
Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System
RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,442 · see citing works
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.
Meltzer, H. Y., Matsubara, S., & Lee, J. C. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20710-8 · Cited by 1,352 · see citing works
Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs
Olney, J. W., Labruyere, J., & Price, M. T. (1989) · Science · doi:10.1126/science.2660263 · Cited by 1,250 · see citing works
Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia
Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M. J., Wible, C. G., Hokama, H., Martin, J., Metcalf, D., Coleman, M., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208273270905 · Cited by 1,178 · see citing works
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 946 · see citing works
Positron Emission Tomography Reveals Elevated D 2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E., Ravert, H. T., Wilson, A. A., et al. (1986) · Science · doi:10.1126/science.2878495 · Cited by 928 · see citing works
Duration of psychosis and outcome in first-episode schizophrenia
Loebel, A. D., Lieberman, J. A., Alvir, J. M., Mayerhoff, D. I., Geisler, S. H., & Szymanski, S. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1183 · Cited by 880 · see citing works
Drugs, Neurotransmitters, and Schizophrenia
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. A. (1974) · Science · doi:10.1126/science.184.4143.1243 · Cited by 834 · see citing works
Metabotropic glutamate receptors in brain function and pathology
Schoepp, D. D., & Conn, P. J. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90107-u · Cited by 793 · see citing works
Neurobiology of Cingulate Cortex and Limbic Thalamus
Vogt, B. A., & Gabriel, M. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6704-6 · Cited by 772 · see citing works
Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia
Barta, P. E., Pearlson, G. D., Powers, R. E., Richards, S. S., & Tune, L. E. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.11.1457 · Cited by 740 · see citing works
Agonists and antagonists for excitatory amino acid receptors
Watkins, J. C., & Olverman, H. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90171-8 · Cited by 694 · see citing works
Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging
Andreasen, N. C., Arndt, S. V., Swayze, V. W., Cizadlo, T., Flaum, M. A., OʼLeary, D. S., Ehrhardt, J. C., & Yuh, W. T. C. (1994) · Science · doi:10.1126/science.7939669 · Cited by 694 · see citing works
Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development
Akbarian, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150007001 · Cited by 679 · see citing works
Tardive Dyskinesia
Kane, J. M. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290040069010 · Cited by 654 · see citing works
Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
Simmons, M. L., Frondoza, C. G., & Coyle, J. T. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90101-s · Cited by 631 · see citing works
Self-citation
National Institute of Mental Health Longitudinal Study of Chronic Schizophrenia: Prognosis and Predictors of Outcome
Breier, A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810270051007 · Cited by 626 · see citing works
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.
Rothstein, J. D., Jin, L., Dykes‐Hoberg, M., & Kuncl, R. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6591 · Cited by 623 · see citing works
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
Allsopp, T. E., Wyatt, S. L., Paterson, H. F., & Davies, A. M. (1993) · Cell · doi:10.1016/0092-8674(93)90230-n · Cited by 575 · see citing works
The Genetics of Schizophrenia: A Current, Genetic-epidemiologic Perspective
Kendler, K. S., & Diehl, S. R. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.2.261 · Cited by 568 · see citing works
Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia
Moghaddam, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13387.x · Cited by 567 · see citing works
Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics
Pakkenberg, B. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230039007 · Cited by 566 · see citing works
Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics
Benes, F. M. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800010033004 · Cited by 503 · see citing works
Antipsychotic Drugs, Neurotransmitters, and Schizophrenia
Carlsson, A. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.2.164 · Cited by 499 · see citing works
Phencyclidine-induced psychosis
Rm, A., & Young, S. J. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.9.1081 · Cited by 478 · see citing works
Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains
Tsai, G. E. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220039008 · Cited by 455 · see citing works
Myelination of Cortical-hippocampal Relays During Late Adolescence
Benes, F. M. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.4.585 · Cited by 448 · see citing works
Limbic pathology in schizophrenia: The entorhinal region—a morphometric study
Falkai, P., Bogerts, B., & Rozumek, M. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90162-x · Cited by 441 · see citing works
Excitatory amino acid transmission
Hicks, T. P., Lodge, D., Mclennan, H., Hardy, J., & Cowburn, R. F. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80857-8 · Cited by 432 · see citing works
Hippocampal Pathologic Findings in Schizophrenia
Jeste, D. V. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110061009 · Cited by 427 · see citing works
Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia
Zipursky, R. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030027004 · Cited by 425 · see citing works
N -Acetylaspartate in neuropsychiatric disorders
Tsai, G. E., & Coyle, J. T. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00014-m · Cited by 422 · see citing works
Self-citation
Increases in cortical depth and glia numbers in rats subjected to enriched environment
Diamond, M. C., Law, F., Rhodes, H., Lindner, B., Rosenzweig, M. R., Krech, D., & Bennett, E. L. (1966) · Journal of Comparative Neurology · doi:10.1002/cne.901280110 · Cited by 419 · see citing works
GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS
Olney, J. W. (1971) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197101000-00008 · Cited by 416 · see citing works
Excitotoxic Amino Acids and Neuropsychiatric Disorders
Olney, J. W. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.000403 · Cited by 407 · see citing works
Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum
Schwarcz, R. M., Creese, I., Coyle, J. T., & Snyder, S. H. (1978) · Nature · doi:10.1038/271766a0 · Cited by 400 · see citing works
Self-citation
Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia
Deakin, J. F. W., Slater, P., Simpson, M. D. C., Gilchrist, A., Skan, W., Royston, M. C., Reynolds, G. P., & Cross, A. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07257.x · Cited by 386 · see citing works
Differential rearing effects on rat visual cortex synapses.
Sirevaag, A. M., & Greenough, W. T. (1987) · Brain Research · doi:10.1016/0006-8993(87)91477-6 · Cited by 370 · see citing works
Amelioration of negative symptoms in schizophrenia by glycine
Javitt, D. C., Zylberman, I., Zukin, S. R., Heresco‐Levy, U., & Lindenmayer, J. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1234 · Cited by 353 · see citing works
D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
Dragunow, M., Robertson, G. S., Faull, R. L. M., Robertson, H. A., & Jansen, K. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90399-o · Cited by 341 · see citing works
Schizophrenia: A Subcortical Neurotransmitter Imbalance Syndrome?
Carlsson, M. L., & Carlsson, A. C. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.3.425 · Cited by 341 · see citing works
Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?
Matthysse, S. (1973) · PubMed · Cited by 338 · see citing works
D1 and D2 dopamine receptors differentially regulate c-fos expression in striatonigral and striatopallidal neurons
Robertson, G. S., Vincent, S. R., & Fibiger, H. C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90096-k · Cited by 328 · see citing works
Principles of Neural Science, 3rd ed
Bloom, F. E. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1739 · Cited by 326 · see citing works
Cerebral Ventricular Enlargement in Chronic Schizophrenia
Weinberger, D. R. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780140013001 · Cited by 326 · see citing works
Glutamatergic Control of Dopamine Release in the Rat Striatum: Evidence for Presynaptic N‐Methyl‐D‐Aspartate Receptors on Dopaminergic Nerve Terminals
Krebs, M., Desce, J. M., Kemel, M. L., Gauchy, C., Godeheu, G., Chéramy, A., & Glowinski, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02565.x · Cited by 325 · see citing works
Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.
Robertson, G. S., Matsumura, H., & Fibiger, H. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23800-9 · Cited by 311 · see citing works
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.
Robinson, M. B., Blakely, R., Couto, R., & Coyle, J. T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47823-4 · Cited by 306 · see citing works
Self-citation
A Longitudinal Study of Symptom Dimensions in Schizophrenia
Arndt, S. V. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950170026004 · Cited by 304 · see citing works
Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients
Benes, F. M., Sorensen, I., & Bird, E. D. (1991) · Schizophrenia Bulletin · doi:10.1093/schbul/17.4.597 · Cited by 285 · see citing works
Psychopathology and the Brain
Carroll, B. J., & Barrett, J. E. (1991) · Medical Entomology and Zoology · Cited by 278 · see citing works
Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis
Gunne, L., Häggström, J.-E., & Sjöquist, B. (1984) · Nature · doi:10.1038/309347a0 · Cited by 255 · see citing works
Structural Abnormalities in the Cerebral Cortex of Chronic Schizophrenic Patients
Weinberger, D. R. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780090021002 · Cited by 254 · see citing works
Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
GOFF, D. C., Tsai, G. E., Manoach, D. S., & Coyle, J. T. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1213 · Cited by 243 · see citing works
Self-citation
Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem
Kerwin, R. W., Patel, S., & Meldrum, B. S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90219-t · Cited by 242 · see citing works
Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
Harrison, P. J., McLaughlin, D. P., & Kerwin, R. W. (1991) · The Lancet · doi:10.1016/0140-6736(91)93392-m · Cited by 240 · see citing works
MK‐801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex
Sharp, F. R., Jasper, P., Hall, J., Noble‐Haeusslein, L. J., & Sagar, S. M. (1991) · Annals of Neurology · doi:10.1002/ana.410300609 · Cited by 235 · see citing works
Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals.
Maura, G., Giardi, A., & Raiteri, M. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13418-6 · Cited by 230 · see citing works
INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIA
Bird, E. D., SPOKES, E. G. S., & Iversen, L. L. (1979) · Brain · doi:10.1093/brain/102.2.347 · Cited by 211 · see citing works
Advancing a Neurodevelopmental Origin for Schizophrenia
Bloom, F. E. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150074008 · Cited by 203 · see citing works
Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia
Nishikawa, T., Takashima, M., & Toru, M. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90046-0 · Cited by 199 · see citing works
Synapses, circuits, and the beginnings of memory
LYNCH, G. S., Shepherd, G. M., Black, I. B., & Killackey, H. P. (1986) · Medical Entomology and Zoology · Cited by 198 · see citing works
Reduced brain N ‐acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus‐seropositive individuals
Meyerhoff, D. J., MacKay, S., Bachman, L., Poole, N., Dillon, W. P., Weiner, M. W., & Fein, G. (1993) · Neurology · doi:10.1212/wnl.43.3_part_1.509 · Cited by 197 · see citing works
Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application
Robinson, M. B., & Coyle, J. T. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.6.2890549 · Cited by 196 · see citing works
Self-citation
Neurotransmitters, receptors and neuropeptides in post‐mortem brains of chronic schizophrenic patients
Toru, M., Watanabe, S., Shibuya, H., Nishikawa, T., Noda, K., Mitsushio, H., Ichikawa, H., Kurumaji, A., Takashima, M., Mataga, N., et al. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb06312.x · Cited by 191 · see citing works
Presynaptic Glutamate Receptors Modulate Dopamine Release from Striatal Synaptosomes
Wang, J. K. T. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08224.x · Cited by 188 · see citing works
Hippocampal Neuron Number in Schizophrenia
Heckers, S. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350042006 · Cited by 188 · see citing works
Excitatory amino acid analogues: Neurotoxicity and seizures
Zaczek, R. C., & Coyle, J. T. (1982) · Neuropharmacology · doi:10.1016/0028-3908(82)90205-2 · Cited by 187 · see citing works
Self-citation
Latency variability of the components of auditory event-related potentials to infrequent stimuli in aging, Alzheimer-type dementia, and depression
Patterson, J. V., Michalewski, H. J., & Starr, A. (1988) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(88)90049-4 · Cited by 185 · see citing works
Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia
Grace, A. A. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245228 · Cited by 185 · see citing works
ASYMMETRICAL LOSS OF GLUTAMATE RECEPTOR SUBTYPE IN LEFT HIPPOCAMPUS IN SCHIZOPHRENIA
Kerwin, R. W., Patel, S., Meldrum, B. S., Czudek, C., & Reynolds, G. P. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91371-2 · Cited by 177 · see citing works
d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes
Watson, G. B., Bolanowski, M. A., Baganoff, M. P., Deppeler, C. L., & Lanthorn, T. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90745-w · Cited by 172 · see citing works
Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs
Fitzgerald, L., Deutch, A., Gasic, G. P., Heinemann, S., & Nestler, E. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02453.1995 · Cited by 171 · see citing works
Organization of dopamine D1 and D2 receptors in human striatum: Receptor autoradiographic studies in Huntington's disease and schizophrenia
Joyce, J. N., Lexow, N., Bird, E., & Winokur, A. (1988) · Synapse · doi:10.1002/syn.890020511 · Cited by 167 · see citing works
3H-flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors
Cross, A. J., Crow, T. J., & Owen, F. (1981) · Psychopharmacology · doi:10.1007/bf00432676 · Cited by 164 · see citing works
Strong Inference, Theory Testing, and the Neuroanatomy of Schizophrenia
Carpenter, W. T. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820220081009 · Cited by 163 · see citing works
Treatment of tardive dyskinesia with vitamin E
Egan, M. F., Hyde, T. M., Albers, G. W., et al. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.6.773 · Cited by 150 · see citing works
The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum.
Konradi, C. L., Kobierski, L. A., Nguyen, T., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7005 · Cited by 146 · see citing works
Vitamin E treatment of tardive dyskinesia
Adler, L. A., Peselow, E. D., Rotrosen, J., Duncan, E., Lee, M., Rosenthal, M., & Angrist, B. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1405 · Cited by 142 · see citing works
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor.
Henderson, G., Johnson, J. W., & Ascher, P. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018288 · Cited by 141 · see citing works
[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics
Hanada, S., Mita, T., Nishino, N., & Tanaka, C. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90341-9 · Cited by 140 · see citing works
Increased Rate of P300 Latency Prolongation With Age in Schizophrenia
O’Donnell, B. F. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950190026004 · Cited by 131 · see citing works
Comparison of Phencyclidine Hydrochloride (Sernyl) with Other Drugs
Cohen, B. D. (1962) · Archives of General Psychiatry · doi:10.1001/archpsyc.1962.01710230063007 · Cited by 131 · see citing works
Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization.
Slusher, B. S., Robinson, M. B., Tsai, G. E., Simmons, M. L., Richards, S. S., & Coyle, J. T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45359-2 · Cited by 129 · see citing works
Self-citation
Dyskinesia. Research and treatment.
Casey, D. E. (1985) · PubMed · Cited by 127 · see citing works
Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat
Mitchell, I., Lawson, S. J., Moser, B., et al. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90002-7 · Cited by 115 · see citing works
N‐Acetylaspartylglutamate Inhibits Forskolin‐Stimulated Cyclic AMP Levels via a Metabotropic Glutamate Receptor in Cultured Cerebellar Granule Cells
Wróblewska, B., Wroblewski, J. T., Saab, O. H., et al. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03606.x · Cited by 110 · see citing works
Actions of ?-cycloserine at the ? glycine receptor site in vivo
Emmett, M. R. (1991) · Neuropharmacology · doi:10.1016/0028-3908(91)90161-4 · Cited by 108 · see citing works
Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine
Sharp, F. R., Butman, M., Wang, S., et al. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330413 · Cited by 107 · see citing works
A 5-year prospective longitudinal study of tardive dyskinesia: factors predicting appearance of new cases.
Chouinard, G., Annable, L., Ross‐Chouinard, A., & Mercier, P. (1988) · PubMed · Cited by 102 · see citing works
Glutamatergic Control of Dopamine Release During Stress in the Rat Prefrontal Cortex
Jedema, H. P., & Moghaddam, B. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63020785.x · Cited by 100 · see citing works
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells
Puttfarcken, P. S., Getz, R. L., & Coyle, J. T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90081-w · Cited by 99 · see citing works
Self-citation
Modulatory Effect of Dopamine on High‐Affinity Glutamate Uptake in the Rat Striatum
Goff, L. K., Dusticier, N., & Nieoullon, A. L. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05661.x · Cited by 98 · see citing works
Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity
Farber, N. B., Price, M. T., Labruyere, J., Nemnich, J., Peter, H. S., Wozniak, D. F., & Olney, J. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90265-f · Cited by 97 · see citing works
Prospects for research on schizophrenia. An hypotheses suggesting that there is a defect in the GABA system in schizophrenia.
Roberts, E. (1972) · PubMed · Cited by 97 · see citing works
Immunocytochemical localization of the N‐acetyl‐aspartyl‐glutamate (NAAG) hydrolyzing enzyme N‐acetylated α‐linked acidic dipeptidase (NAALADase)
Slusher, B. S., Tsai, G. E., Yoo, G., et al. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903150208 · Cited by 93 · see citing works
d-Cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label study
Cascella, N. G., Macciardi, F. M., Cavallini, M. C., & Smeraldi, E. (1994) · Journal of Neural Transmission · doi:10.1007/bf01276429 · Cited by 92 · see citing works
Event-related potentials in patients with Huntington's disease and relatives at risk in relation to detailed psychometry
Hömberg, V., Hefter, H., Granseyer, G., Strauß, W. H., Lange, H., & Hennerici, M. G. (1986) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(86)90143-4 · Cited by 91 · see citing works
Contemporary Issues in the Treatment of Schizophrenia
Shriqui, C. L., & Nasrallah, H. A. (1995) · Medical Entomology and Zoology · Cited by 87 · see citing works
Kainic acid induces apoptosis in neurons
Simonian, N. A., Getz, R. L., Leveque, J., et al. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00326-0 · Cited by 87 · see citing works
The Neurobiology of N-Acetylasparty
Blakely, R., & Coyle, J. T. (1988) · International review of neurobiology · doi:10.1016/s0074-7742(08)60046-x · Cited by 85 · see citing works
Self-citation
Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls
Yurgelun-Todd, D. A., Renshaw, P. F., Gruber, S. A., WATERNAUX, C. M., & Cohen, B. M. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(95)00071-2 · Cited by 83 · see citing works
Selective release ofN-acetylaspartylglutamate from rat optic nerve terminals in vivo
Tsai, G. E., Stauch, B. L., Vornov, J. J., et al. (1990) · Brain Research · doi:10.1016/0006-8993(90)90989-o · Cited by 82 · see citing works
Blockade of long-term potentiation by phencyclidine and σ opiates in the hippocampus in vivo and in vitro
Stringer, J. L., Greenfield, L. J., Hackett, J. T., & Guyenet, P. G. (1983) · Brain Research · doi:10.1016/0006-8993(83)91180-0 · Cited by 82 · see citing works
DOPAMINE RECEPTORS AND SCHIZOPHRENIA: DRUG EFFECT OR ILLNESS?
Mackay, A. V. P., Bird, E. D., SPOKES, E. G. S., et al. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92072-3 · Cited by 81 · see citing works
Low-concentration N-acetylaspartylglutamate suppresses the climbing fiber response of Purkinje cells in Guinea pig cerebellar slices and the responses to excitatory amino acids of Xenopus laevis oocytes injected with cerebellar mRNA
Sekiguchi, M., Okamoto, K., & Sakai, Y. (1989) · Brain Research · doi:10.1016/0006-8993(89)90545-3 · Cited by 78 · see citing works
Glutamate-positive corticocortical neurons in the somatic sensory areas I and II of cats
Conti, F., Mara Fabri, C., & Manzoni, T. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02948.1988 · Cited by 75 · see citing works
An unusual cluster of tardive dyskinesia in schizophrenia: association with cognitive dysfunction and negative symptoms
Waddington, J. L., & Youssef, H. A. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.9.1162 · Cited by 74 · see citing works
Phencyclidine poisoning in young children
Karp, H., Kaufman, N., & Anand, S. (1980) · The Journal of Pediatrics · doi:10.1016/s0022-3476(80)80447-1 · Cited by 69 · see citing works
d-Cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-d-aspartate receptor-ionophore complex in Alzheimer brain
Chessell, I. P., PROCTER, A. W., Francis, P. T., & Bowen, D. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)91668-q · Cited by 66 · see citing works
Glycine modulation of the phencyclidine binding site in mammalian brain
Thomas, J. W., Hood, W. F., Monahan, J. B., Contreras, P. C., & O’Donohue, T. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91533-8 · Cited by 63 · see citing works
Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?
LAWLOR, B. A., & Davis, K. L. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90227-q · Cited by 63 · see citing works
Efficacy of clozapine compared with other antipsychotics in preventing NMDA-antagonist neurotoxicity.
Olney, J. W., & Farber, N. B. (1994) · PubMed · Cited by 62 · see citing works
Sampling Biases in Studies of Gender and Schizophrenia
Walker, E. F., & Lewine, R. R. J. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.1.1 · Cited by 59 · see citing works
Is There a Neuroanatomic Basis for Schizophrenia? An Old Question Revisited
Benes, F. M. (1995) · The Neuroscientist · doi:10.1177/107385849500100207 · Cited by 58 · see citing works
Effect of the glycine/NMDA receptor partial agonist, D-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice
Właź, P., Baran, H., & Löscher, W. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90132-5 · Cited by 47 · see citing works
Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia
Andersson, U., Hägström, J., Levin, E. D., et al. (1989) · Movement Disorders · doi:10.1002/mds.870040107 · Cited by 44 · see citing works
The association among negative symptoms, movement disorders, and frontal lobe psychological deficits in schizophrenic patients
Brown, K. W., & White, T. G. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90154-e · Cited by 40 · see citing works
Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay
Guarda, Á. S., Robinson, M. B., Ory‐Lavollée, L., Forloni, G., Blakely, R., & Coyle, J. T. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90045-9 · Cited by 37 · see citing works
Self-citation
Negative symptoms of schizophrenia: The need for conceptual clarity
Tandon, R., & Greden, J. F. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90287-v · Cited by 36 · see citing works
Immunocytochemical distribution of n-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways
Tsai, G. E., Slusher, B. S., Sim, L., et al. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90033-z · Cited by 34 · see citing works
Mode of Action, Biotransformation and Pharmacokinetics of Antituberculosis Drugs in Animals and Man
Iwainsky, H. (1988) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-72873-0_6 · Cited by 27 · see citing works
Computed tomographic evaluation of patients with tardive dyskinesia
Hoffman, W. F., & Casey, D. E. (1991) · Schizophrenia Research · doi:10.1016/0920-9964(91)90048-v · Cited by 26 · see citing works
Heredity and Environment in Schizophrenia, Revisited
Stabenau, J. R., & Pollin, W. (1993) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199305000-00003 · Cited by 24 · see citing works
Biochemical analysis of glial fibrillary acidic protein as a quantitative approach to neurotoxicity assessment: advantages, disadvantages and application to the assessment of NMDA receptor antagonist-induced neurotoxicity.
Jp, O. (1994) · PubMed · Cited by 23 · see citing works
Elevated D 2 Dopamine Receptors in Drug-Naïve Schizophrenics
Zeebèrg, B. R., Gibson, R. E., & Reba, R. C. (1988) · Science · doi:10.1126/science.2963379 · Cited by 18 · see citing works
Glutamate and schizophrenia
Kornhuber, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90177-a · Cited by 18 · see citing works
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase
Meyerhoff, J. L., Robinson, M. B., Koller, K. J., et al. (1992) · Elsevier eBooks · doi:10.1016/b978-0-444-89710-7.50043-4 · Cited by 4 · see citing works
Spontaneous dyskinesia in schizophrenia
Fenton, W. S., Wyatt, R. J., & McGlashan, T. H. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)95637-o · Cited by 3 · see citing works
Abnormal movements in never medicated schizophrenics
Hoffman, W. F., Kadria, N., Fenn, D. S., et al. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)95639-q · Cited by 3 · see citing works

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A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988 · see citing works
Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
Wang, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09587.1999 · Cited by 859 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Glutamatergic mechanisms in schizophrenia
Tsai, G., & Coyle, J. T. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.160735 · Cited by 577 · see citing works
Self-citation
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530 · see citing works
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514 · see citing works
GABAergic interneuron origin of schizophrenia pathophysiology
Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498 · see citing works
Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia
Phillips, W. A., & Silverstein, S. M. (2003) · Behavioral and Brain Sciences · doi:10.1017/s0140525x03000025 · Cited by 445 · see citing works
Density of Glutamic Acid Decarboxylase 67 Messenger RNA–ContainingNeurons That Express the N-Methyl-D-AspartateReceptor Subunit NR2A in the Anterior Cingulate Cortex in Schizophreniaand Bipolar Disorder
Woo, T.-U. W., Walsh, J. P., & Benes, F. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.649 · Cited by 411 · see citing works
Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
Konradi, C., & Heckers, S. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00328-5 · Cited by 336 · see citing works
Has an Angel Shown the Way? Etiological and Therapeutic Implications of the PCP/NMDA Model of Schizophrenia
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The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
Hu, W., MacDonald, M. L., Elswick, D. E., & Sweet, R. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12547 · Cited by 286 · see citing works
Extracellular Matrix-Glial Abnormalities in the Amygdala and Entorhinal Cortex of Subjects Diagnosed With Schizophrenia
Pantazopoulos, H., Woo, T.-U. W., Lim, M. P., Lange, N., & Berretta, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.196 · Cited by 296 · see citing works
Gamma and delta neural oscillations and association with clinical symptoms under subanesthetic ketamine
Hong, L. E., Summerfelt, A., Buchanan, R. W., O'Donnell, P., Thaker, G. K., Weiler, M. A., & Lahti, A. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.168 · Cited by 274 · see citing works
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Extracellular matrix abnormalities in schizophrenia
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Dell’Osso, B., Glick, I. D., Baldwin, D. S., & Altamura, A. C. (2013) · Psychopathology · doi:10.1159/000338608 · Cited by 118 · see citing works
Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex
Zhang, Y., Behrens, M. M., & Lisman, J. E. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00079.2008 · Cited by 107 · see citing works
Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain
Akgül, G., & McBain, C. J. (2016) · The Journal of Physiology · doi:10.1113/jp271764 · Cited by 87 · see citing works
Do hallucinogens cause residual neuropsychological toxicity?
Halpern, J. H., & Pope, H. G. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00129-x · Cited by 82 · see citing works
Significant Association Between the Genetic Variations in the 5′ End of the N-Methyl-D-Aspartate Receptor Subunit Gene GRIN1 and Schizophrenia
Zhao, X., Li, H., Shi, Y., Tang, R., Chen, W., Liu, J., Feng, G., Shi, J., Yan, L., Liu, H., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.023 · Cited by 70 · see citing works
Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia
Begni, S., Popoli, M., Moraschi, S., Bignotti, S., Tura, G. B., & Gennarelli, M. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000987 · Cited by 71 · see citing works
Hippocampal temporal-parietal junction interaction in the production of psychotic symptoms: a framework for understanding the schizophrenic syndrome
Wible, C. G. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00180 · Cited by 56 · see citing works
Altered center-surround motion inhibition in schizophrenia
Chen, Y., Norton, D., & Ongur, D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.017 · Cited by 51 · see citing works
Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men: A Longitudinal Magnetic Resonance Imaging Study
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Lee, R., Sawin, E. R., Chalfie, M., Horvitz, H. R., & Avery, L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00159.1999 · Cited by 351 · see citing works
Glutamatergic Neurotransmission, Aluminium and Alzheimer’s Disease
Felipo, V. (2001) · Elsevier eBooks · doi:10.1016/b978-044450811-9/50042-2 · Cited by 1 · see citing works
Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission
Schousboe, A., Sarup, A., Bak, L. K., Waagepetersen, H. S., & Larsson, O. M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.11.001 · Cited by 142 · see citing works
Effects of polyamines on synaptic transmission, with special attention to the glutamatergic system.
Piek, T., Schluter, N. C. M., & Karst, H. (1991) · PubMed
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Warren, K., & Solomon, I. C. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-73693-8_74 · Cited by 1 · see citing works

Authors: Coyle, J. T.
Affiliations: Harvard University (US)
Corresponding author: Coyle, Joseph T.
ORCID: Coyle, Joseph T.
Venue: Harvard Review of Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-01
Volume: 3
Issue: 5
Pages: 241-253
ISSN: 1067-3229 (ISSN-L)
DOI: 10.3109/10673229609017192
OpenAlex: W2069656785
Cited by: 568
References: 147
Citations by year: 2026: 8 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 15 · 2019: 17 · 2018: 16 · 2017: 14 · 2016: 20 · 2015: 25 · 2014: 15 · 2013: 18 · 2012: 25
FWCI: 14.51
Type: journal article
Language: en
Open access: closed
Locations: Harvard Review of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, glutamatergic dysfunction, NMDA receptor, N-acetylaspartylglutamate, negative symptoms, cognitive impairment, phencyclidine, antipsychotic drugs, frontal cortex, hippocampus, striatum
MeSH terms: Cerebral Cortex, Humans, Nerve Degeneration, Schizophrenia, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Glutamic Acid

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The Glutamatergic Dysfunction Hypothesis for Schizophrenia

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