The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Oxidative Stress and Neurodegeneration
Abstract
A bstract: Oxidative stress is a well‐studied early response in chronic neurodegenerative diseases, including Alzheimer's disease, where neuronal loss can exceed 90% in the vulnerable neuronal population. Oxidative stress affects all classes of macromolecules (sugar, lipids, proteins, and DNA), leading inevitably to neuronal dysfunction. We observed that N ε‐(carboxymethyl)lysine (CML), the predominant advanced glycation end product that accumulates in vivo, along with its glycation‐specific precursor hexitol‐lysine, are increased in neurons from cases of Alzheimer's disease, especially those containing intracellular neurofibrillary pathology. The increase in hexitol‐lysine and CML can result from either lipid peroxidation or advanced glycation, whereas hexitol‐lysine is solely a product of glycation, suggesting that two distinct oxidative processes act in concert in the neuropathology of the disease. Furthermore, using olfactory neurons as an experimental model, we observed an increase in glycation products in neurons derived from Alzheimer's disease patients. Our findings support the idea that aldehyde‐mediated modifications, in concert with oxyradical‐mediated modifications, are critical early pathogenic factors in Alzheimer's disease.
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Cites
Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Self-citationWidespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239
Self-citationSayre, L. M., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,007
Self-citationPearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987
Oxidative damage in Alzheimer's
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Action des acides amines sur les sucres : formation des melanoidines par voie methodique
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Advanced glycation end products contribute to amyloidosis in Alzheimer disease
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174
James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955
Free radicals and antioxidants: updating a personal view
Halliwell, B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 912
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
Metadata
- Authors
- MOREIRA, P. I., SMITH, M. A., ZHU, X., NUNOMURA, A., CASTELLANI, R. J., & PERRY, G.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 1043
- Issue
- 1
- Pages
- 545-552
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1976919988
- Cited by
- 366
- References
- 49
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- MOREIRA, P. I., SMITH, M. A., ZHU, X., NUNOMURA, A., CASTELLANI, R. J., & PERRY, G. (2005). Oxidative Stress and Neurodegeneration. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1333.062
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
