The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Oxygen in the Cultivation of Stem Cells
Abstract
A bstract:Cultivation of stem cells, like all cells in culture, is performed under conditions that cannot and do not replicate normal physiologic conditions. For example, direct exposure of cultured monolayer cells to serum contents is normally prevented in vivo by the vasculature. The heterogeneity of cells and signals between different cell types in an organ is certainly not captured when a single cell type is grown and studied in vitro. Gases, in particular, are not accounted for in routine tissue culture. Oxygen is fundamental for life and its concentration is an important signal for virtually all cellular processes. Nonetheless, oxygen is rarely taken into account in culturing stem and other cells. This review will summarize work that highlights the importance of considering oxygen conditions for culturing and manipulating stem cells. Emphasis is placed on major phenotypic changes in response to oxygen, recognizing that oxygen‐mediated transcriptional and post‐translational effects are enormously complex, and beyond the scope of this review. The review emphasizes that oxygen is an important signal in all major aspects of stem cell biology including proliferation and tumorigenesis, cell death and differentiation, self‐renewal, and migration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Dystrophin expression in the mdx mouse restored by stem cell transplantation
Gussoni, E., Soneoka, Y., Strickland, C. D., Buzney, E. A., Khan, M. K., Flint, A. F., Kunkel, L. M., & Mulligan, R. C. (1999) · Nature · doi:10.1038/43919 · Cited by 1,802
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1024 · Cited by 1,116
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells
Draper, J. S., Smith, K., Gokhale, P., Moore, H. D., Maltby, E., Johnson, J., Meisner, L., Zwaka, T. P., Thomson, J. A., & Andrews, P. W. (2004) · Nature Biotechnology · doi:10.1038/nbt922 · Cited by 1,021
ENGINEERING PRINCIPLES OF CLINICAL CELL-BASED TISSUE ENGINEERING
MUSCHLER, G. F., NAKAMOTO, C., & GRIFFITH, L. G. (2004) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200407000-00029 · Cited by 878
Studer, L., Csete, M., Lee, S.-H., Kabbani, N., Walikonis, J., Wold, B., & McKay, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07377.2000 · Cited by 708
Self-citationHGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
Kollet, O., Shivtiel, S., Chen, Y.-Q., Suriawinata, J., Thung, S. N., Dabeva, M. D., Kahn, J., Spiegel, A., Dar, A., Samira, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17902 · Cited by 593
Transplanted bone marrow generates new neurons in human brains
Mezey, É., Key, S., Vogelsang, G., Szalayova, I., Lange, G. D., & Crain, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336479100 · Cited by 567
Cited by
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
Mitochondrial Energetics and Therapeutics
Wallace, D. C., Fan, W., & Procaccio, V. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092314 · Cited by 730
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
Grayson, W. L., Zhao, F., Bunnell, B., & Ma, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.054 · Cited by 521
Fehrer, C., Brunauer, R., Laschober, G., Unterluggauer, H., Reitinger, S., Kloss, F., Gülly, C., Gaßner, R., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498
Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation
Reing, J. E., Zhang, L., Myers-Irvin, J., Cordero, K. E., Freytes, D. O., Heber-Katz, E., Bedelbaeva, K., McIntosh, D., Dewilde, A., Braunhut, S. J., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0425 · Cited by 387
Metadata
- Authors
- CSETE, M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-05
- Volume
- 1049
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2006079390
- Cited by
- 268
- References
- 44
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxygen in the Cultivation of Stem Cells. https://app.cochat.ai/papers/10.1196/annals.1334.001
- The paper
- CSETE, M. (2005). Oxygen in the Cultivation of Stem Cells. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1334.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
