The Patterns of Uterine Contractility in Normal Menstruating Women: From Physiology to Pathology
Abstract
A bstract: The nonpregnant uterus shows uterine activity throughout the menstrual cycle. This uterine activity was detected both by single strep tissue and by using intrauterine pressure recordings in vitro and in vivo. Today, ultrasound has made it possible to study this activity with a noninvasive approach and to assess uterine contractions (UCs) in real‐time movements of the uterus. Throughout the menstrual cycle, wavelike activity patterns of the reproductive organ were established. These patterns are under control of steroid hormones. Adequate UCs may provide for gamete/embryo transportation throughout the uterotubal cavities and successful embryo implantation in spontaneous and/or assisted reproduction. Inadequate UCs may produce ectopic pregnancy, miscarriages, retrograde bleeding with dysmenorrhea, and endometriosis.
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After pregnancy, endometriosis-associated pain often abates.
“After pregnancy, pain often abates”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Bulletti et al., 2004
The non-pregnant uterus contracts throughout the menstrual cycle.
“The non-pregnant uterus contracts throughout the menstrual cycle”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Bulletti et al., 2004
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Caroff, A., Frontczak, S., Ramanah, R., BLAGLOSKLONOV, O., Berdin, A., Zver, T., Mottet, N., Nallet, C., & Scheffler, F. (2026) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2026.103141
Ortega-Sandoval, K., Lamichhane, A., Davé, R., Frolova, A. I., & Raghavan, S. A. (2026) · Springer eBooks · doi:10.1007/978-3-032-10745-9_8
Yue, Y., Yan, J., Song, Y., Zhou, X., Kang, Y., & Yuan, M. (2026) · Journal of Pregnancy · doi:10.1155/jp/6250135
Savoca, P. W., Lopez, S. D., Khalsa, S. S., & Callaghan, B. L. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101363
- Authors
- BULLETTI, C., DE ZIEGLER, D., SETTI, P. L., CICINELLI, E., POLLI, V., & FLAMIGNI, C.
- Affiliations
- Ospedale Infermi di Rimini (IT)
- University of Bari Aldo Moro (IT)
- University of Bologna (IT)
- Corresponding author
- BULLETTI, CARLO
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 1034
- Issue
- 1
- Pages
- 64-83
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1987618161
- Cited by
- 69
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- uterine contractility, menstrual cycle, intrauterine pressure, steroid hormones, embryo implantation, assisted reproduction, ectopic pregnancy, miscarriage, dysmenorrhea, endometriosis
- MeSH terms
- Dysmenorrhea, Endometritis, Female, Humans, Menstruation, Uterine Contraction, Uterus
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