The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases
Abstract
Initial events and effector mechanisms of most inflammatory and autoimmune diseases remain largely unknown. Dysfunction of the innate and adaptive immune systems associated with mucosae (the major interface between the organism and its environment, e.g., microbiota, food) can conceivably cause impairment of mucosal barrier function and development of localized or systemic inflammatory and autoimmune processes. Animal models help in elucidating the etiology and pathogenetic mechanisms of human diseases, such as the inflammatory bowel diseases, Crohn's disease and ulcerative colitis, severe chronic diseases affecting the gut. To study the role of innate immunity and gut microbiota in intestinal inflammation, colitis was induced by dextran sulfate sodium (DSS) in mice with severe combined immunodeficiency (SCID). Conventionally reared (microflora-colonized) SCID mice displayed severe inflammation like that seen in immunocompetent Balb/c mice, whereas only minor changes appeared in the intestinal mucosa of DSS-fed gnotobiotic germ-free SCID mice. The presence of microflora facilitates the inflammation in DSS-induced colitis that develops in immunodeficient SCID mice, that is, in the absence of T and B lymphocytes. Celiac disease, a chronic autoimmune small bowel disorder, afflicts genetically susceptible individuals with wheat gluten intolerance. We showed that, in contrast with any other food proteins, wheat gliadin and its peptic fragments activate mouse macrophages and human m…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“a mouse model of colitis induced by dextran sulfate sodium (DSS) which mainly depends on the innate immune system7,8”
From Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 (2015) · cites this paper as [7]
Citations
Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Toll-like receptors in the induction of the innate immune response
Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,083
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,687
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Innate immune recognition: mechanisms and pathways
Medzhitov, R., & Janeway, C. J. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917309.x · Cited by 1,506
The Immunology of Mucosal Models of Inflammation
Strober, W., Fuss, I. J., & Blumberg, R. S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064816 · Cited by 1,304
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053
The ABCs of floral homeotic genes
Weigel, D., & Meyerowitz, E. M. (1994) · Cell · doi:10.1016/0092-8674(94)90291-7 · Cited by 1,018
Coeliac disease: dissecting a complex inflammatory disorder
Sollid, L. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri885 · Cited by 964
Tlaskalová-Hogenová, H., Štěpánková, R., Hudcovic, T., Tučková, L., Cukrowska, B., Lodinová-Žádnı́ková, R., Kozáková, H., Rossmann, P., Bártová, J., Sokol, D., et al. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.02.005 · Cited by 755
Self-citationFasano, A., Not, T., Wang, W., Uzzau, S., Berti, I., Tommasini, A., & Goldblum, S. E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02169-3 · Cited by 668
Control of intestinal inflammation by regulatory T cells
Singh, B., Read, S., Asseman, C., Malmström, V., Mottet, C., Stephens, L. A., Štëpánková, R., Tlaskalová, H., & Powrie, F. M. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820115.x · Cited by 500
Self-citationInflammatory bowel disease: the role of environmental factors
Danese, S., Sans, M., & Fiocchi, C. (2004) · Autoimmunity Reviews · doi:10.1016/j.autrev.2004.03.002 · Cited by 427
Extensive Set of 16S rRNA-Based Probes for Detection of Bacteria in Human Feces
Harmsen, H. J. M., Raangs, G. C., He, T., Degener, J. E., & Welling, G. W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.6.2982-2990.2002 · Cited by 401
PASSCLAIM1?Gut health and immunity
Cummings, J. H., Antoine, J.-M., Azpiroz, F., Bourdet-Sicard, R., Brandtzaeg, P., Calder, P. C., Gibson, G. R., Guarner, F., Isolauri, E., Pannemans, D., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1205-4 · Cited by 324
Let's go mucosal: communication on slippery ground
Brandtzaeg, P., & Pabst, R. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.005 · Cited by 309
Let's go mucosal: communication on slippery ground
Brandtzæg, P., & Pabst, R. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.11.009 · Cited by 236
Recent Developments in the Immunology of Inflammatory Bowel Disease
MacDonald, Monteleone, & Pender (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00658.x · Cited by 197
Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice
Strober, W., & Ehrhardt, R. O. (1993) · Cell · doi:10.1016/0092-8674(93)80062-j · Cited by 185
Eat Dirt — The Hygiene Hypothesis and Allergic Diseases
Weiss, S. T. (2002) · New England Journal of Medicine · doi:10.1056/nejme020092 · Cited by 182
Advances in Mucosal Immunology
Mestecky, J. F., Russell, M. W., Jackson, S., Michalek, S. M., Tlaskalová‐Hogenová, H., & Šterzl, J. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1941-6 · Cited by 165
Self-citationFunda, D., Tučková, L., Farré, M., Iwase, T., Moro, I., & Tlaskalova-Hogenova, H. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.3772-3781.2001 · Cited by 147
Lodinová‐Žádníková, R., Cukrowská, B., & Tlaskalová‐Hogenová, H. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000071488 · Cited by 143
Self-citationCukrowská, B., Lodinová‐Žádníková, R., Enders, C., Sonnenborn, U., Schulze, J., & Tlaskalová‐Hogenová, H. (2002) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2002.01005.x · Cited by 114
Self-citationMucosal Immunity: Its Role in Defense and Allergy
Tlaskalová‐Hogenová, H., Tučková, L., Lodinová‐Žádníková, R., Štëpánková, R., Cukrowská, B., Funda, D. P., Stříž, I., Kozáková, H., Trebichavský, I., Sokol, D., et al. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000059397 · Cited by 113
Self-citationHudcovic, T., Štëpánková, R., Cebra, J. J., & Tlaskalová-Hogenová, H. (2001) · Folia Microbiologica · doi:10.1007/bf02818004 · Cited by 99
Self-citationJelinkova, L. P., Tučková, L., Cinová, J., Flegelová, Z., & Tlaskalová-Hogenová, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.057 · Cited by 99
Self-citationWheat Gluten Causes Dendritic Cell Maturation and Chemokine Secretion
Nikulina, M., Habich, C., Flohé, S. B., Scott, F. W., & Kolb, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1925 · Cited by 94
The Paneth cell and the innate immune response
Bevins, C. L. (2004) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200411000-00012 · Cited by 92
DEVELOPMENT OF IMMUNOLOGICAL CAPACITY UNDER GERMFREE AND CONVENTIONAL CONDITIONS
Tlaskalová‐Hogenová, H., Šterzl, J., Štëpánková, R., Dlabač, V., Větvička, V., Rossmann, P., Mandel, L., & Rejnek, J. (1983) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1983.tb26862.x · Cited by 91
Self-citationShoenfeld, Y., & Cohen, I. R. (1987) · Elsevier eBooks · doi:10.1016/b978-0-12-635507-9.50010-6 · Cited by 87
Activation of macrophages by gliadin fragments: isolation and characterization of active peptide
Tučková, L., Novotná, J., Novák, P., Flegelová, Z., Květoň, T., Jelinkova, L. P., Zídek, Z., Man, P., & Tlaskalová‐Hogenová, H. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.625 · Cited by 81
Self-citationIntestinal zonulin: open sesame!
Fasano, A. (2001) · Gut · doi:10.1136/gut.49.2.159 · Cited by 80
Bendjelloul, F., Malý, P., Mandys, V., Jirkovská, M., Prokešová, L., Tučková, L., & Tlaskalová‐Hogenová, H. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01090.x · Cited by 78
Self-citationProbiotics and down-regulation of the allergic response
Kalliomäki, M. A., & Isolauri, E. (2004) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2004.06.006 · Cited by 75
Toll-like Receptors and their Role in the Development of Autoimmune Diseases
Toubi, E., & Shoenfeld, Y. (2004) · Autoimmunity · doi:10.1080/08916930410001704944 · Cited by 74
Nuclear factor κB is activated in small intestinal mucosa of celiac patients
Maiuri, M. C., Stefano, D. D., Mele, G., Fecarotta, S., Greco, L., Troncone, R., & Carnuccio, R. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0440-0 · Cited by 65
Rose, N. R. (2002) · Seminars in Liver Disease · doi:10.1055/s-2002-35708 · Cited by 62
Changes in Jejunal Mucosa after Long-Term Feeding of Germfree Rats with Gluten
Štëpánková, R., Tlaskalová‐Hogenová, H., Šinkora, J., Jodl, J., & Fric, P. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609009127 · Cited by 60
Self-citationKrupičková, S., Tučková, L., Flegelová, Z., Michalak, M., Walters, J. R. F., Whelan, A. M., Harries, J., Vencovský, J., & Tlaskalová‐Hogenová, H. (1999) · Gut · doi:10.1136/gut.44.2.168 · Cited by 47
Self-citationInnate immunity and coeliac disease
Schuppan, D., Esslinger, B., & Dieterich, W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13843-3 · Cited by 45
Innate immunity in the pathogenesis and therapy of IBD.
Sartor, R. B. (2003) · PubMed · Cited by 38
Tučková, L., Flegelová, Z., Tlaskalová‐Hogenová, H., & Zı́dek, Z. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.3.312 · Cited by 38
Self-citationCebra, J. J., Jiang, H.-Q., Boyko, N., & Tlaskalová‐Hogenová, H. (2005) · Elsevier eBooks · doi:10.1016/b978-012491543-5/50022-x · Cited by 28
Self-citationAutoimmunity and environmental factors in the pathogenesis of primary biliary cirrhosis
Kita, H., He, X.-S., & Gershwin, M. E. (2004) · Annals of Medicine · doi:10.1080/07853890310018467 · Cited by 25
Animal Models of Intestinal Inflammation: Clues to the Pathogenesis of Inflammatory Bowel Disease
Powrie, F. M., & Uhlig, H. H. (2004) · Novartis Foundation symposium · doi:10.1002/0470090480.ch12 · Cited by 23
Self-citationCellular and Molecular Basis for Antigen Transport Across Epithelial Barriers
Neutra, M. R., & Kraehenbühl, J.-P. (2005) · Elsevier eBooks · doi:10.1016/b978-012491543-5/50011-5 · Cited by 21
Introduction: Infection and Autoimmunity
Shoenfeld, Y., & Rose, N. R. (2004) · Elsevier eBooks · doi:10.1016/b978-044451271-0.50001-6 · Cited by 19
Kozáková, H., Řeháková, Z., & Kolinska, J. (2001) · Folia Microbiologica · doi:10.1007/bf02818005 · Cited by 19
Self-citationNovák, P., Man, P., Tučková, L., Tlaskalová‐Hogenová, H., Bezouška, K., & Havlı́ček, V. (2002) · Journal of Mass Spectrometry · doi:10.1002/jms.305 · Cited by 12
Self-citationGene Disruption and Immunity in Experimental Colitis
Elson, C. O., Konrad, A., Cong, Y., & Weaver, C. T. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200402001-00005 · Cited by 9
Gnotobiology as a tool -An introduction
Tlaskalová-Hogenová, H. (1996) · Elsevier eBooks · doi:10.1016/b978-012442710-5.50170-2 · Cited by 9
Self-citation
Research works printed but not linked: 1
- 4Mestecky, J., M.E. Lamm, W. Strober, et al. 2005. Mucosal Immunology, 3rd ed. Elsevier Academic Press. Amsterdam.
Cited by
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology · doi:10.1038/ni.1736 · Cited by 756
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378
Tang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.003 · Cited by 285
Metadata
- Authors
- TLASKALOVÁ-HOGENOVÁ, H., TUCKOVÁ, L., STEPÁNKOVÁ, R., HUDCOVIC, T., PALOVÁ-JELÍNKOVÁ, L., KOZÁKOVÁ, H., ROSSMANN, P., SANCHEZ, D., CINOVÁ, J., HRNČÍŘ, T., KVERKA, M., FROLOVÁ, L., UHLIG, H., POWRIE, F., & BLAND, P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 1051
- Issue
- 1
- Pages
- 787-798
- ISSN
- 0077-8923
- 1749-6632
- Cited by
- 68
- References
- 53
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3744 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
