The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases
Abstract
Initial events and effector mechanisms of most inflammatory and autoimmune diseases remain largely unknown. Dysfunction of the innate and adaptive immune systems associated with mucosae (the major interface between the organism and its environment, e.g., microbiota, food) can conceivably cause impairment of mucosal barrier function and development of localized or systemic inflammatory and autoimmune processes. Animal models help in elucidating the etiology and pathogenetic mechanisms of human diseases, such as the inflammatory bowel diseases, Crohn's disease and ulcerative colitis, severe chronic diseases affecting the gut. To study the role of innate immunity and gut microbiota in intestinal inflammation, colitis was induced by dextran sulfate sodium (DSS) in mice with severe combined immunodeficiency (SCID). Conventionally reared (microflora-colonized) SCID mice displayed severe inflammation like that seen in immunocompetent Balb/c mice, whereas only minor changes appeared in the intestinal mucosa of DSS-fed gnotobiotic germ-free SCID mice. The presence of microflora facilitates the inflammation in DSS-induced colitis that develops in immunodeficient SCID mice, that is, in the absence of T and B lymphocytes. Celiac disease, a chronic autoimmune small bowel disorder, afflicts genetically susceptible individuals with wheat gluten intolerance. We showed that, in contrast with any other food proteins, wheat gliadin and its peptic fragments activate mouse macrophages and human m…
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“a mouse model of colitis induced by dextran sulfate sodium (DSS) which mainly depends on the innate immune system7,8”
From Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 (2015) · cites this paper as [7]
Citations
Cites
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
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Toll-like receptors in the induction of the innate immune response
Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,083
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,687
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Innate immune recognition: mechanisms and pathways
Medzhitov, R., & Janeway, C. J. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917309.x · Cited by 1,506
The Immunology of Mucosal Models of Inflammation
Strober, W., Fuss, I. J., & Blumberg, R. S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064816 · Cited by 1,304
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053
The ABCs of floral homeotic genes
Weigel, D., & Meyerowitz, E. M. (1994) · Cell · doi:10.1016/0092-8674(94)90291-7 · Cited by 1,018
Coeliac disease: dissecting a complex inflammatory disorder
Sollid, L. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri885 · Cited by 964
Research works printed but not linked: 1
- 4Mestecky, J., M.E. Lamm, W. Strober, et al. 2005. Mucosal Immunology, 3rd ed. Elsevier Academic Press. Amsterdam.
Cited by
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology · doi:10.1038/ni.1736 · Cited by 756
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378
Tang, C., Kamiya, T., Liu, Y., Kadoki, M., Kakuta, S., Oshima, K., Hattori, M., Takeshita, K., Kanai, T., Saijo, S., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.07.003 · Cited by 285
Severance, E. G., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Khushalani, S., Leweke, F. M., Dickerson, F. B., & Yolken, R. H. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.018 · Cited by 243
Heimesaat, M. M., Fischer, A., Siegmund, B., Kupz, A., Niebergall, J., Fuchs, D., Jahn, H.-K., Freudenberg, M., Loddenkemper, C., Batra, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000662 · Cited by 213
Sun, W., Han, X., Wu, S., Wu, J., Yang, C., & Li, X. (2020) · Inflammopharmacology · doi:10.1007/s10787-019-00678-2 · Cited by 31
Metadata
- Authors
- TLASKALOVÁ-HOGENOVÁ, H., TUCKOVÁ, L., STEPÁNKOVÁ, R., HUDCOVIC, T., PALOVÁ-JELÍNKOVÁ, L., KOZÁKOVÁ, H., ROSSMANN, P., SANCHEZ, D., CINOVÁ, J., HRNČÍŘ, T., KVERKA, M., FROLOVÁ, L., UHLIG, H., POWRIE, F., & BLAND, P.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2005-06
- Volume
- 1051
- Issue
- 1
- Pages
- 787-798
- ISSN
- 0077-8923
- 1749-6632
- Cited by
- 68
- References
- 53
- Language
- en
- Licence
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3744 d)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
