Cited by 309Adipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and ManagementAdipose Tissue and Metabolism

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Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, KRYSTALLENIA, PIPERI, CHRISTINA, KALOFOUTIS, CHRISTOS, SINGH, JAIPAUL, ALAVERAS, ANTONIS, KALOFOUTIS, ANASTASIOS·2006·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1372.039

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Abstract

Abstract: Population‐based studies have shown strong relationship between inflammatory markers and metabolic disturbances, obesity, and atherosclerosis, whereas inflammation has been considered as a “common soil” between these clinical entities and type 2 diabetes (T2D). The accumulation of macrophages in adipose tissue (AT), the common origin of macrophages and adipocytes, the prevalent presence of peripheral mononuclear cells, and apoptotic β cells by themselves seem to be the sources of inflammation present in T2D, since they generate the mediators of the inflammatory processes, namely cytokines. The main cytokines involved in the pathogenesis of T2D are interleukin‐1β (IL‐1β), with an action similar to the one present in type 1 diabetes, tumor necrosis factor‐α (TNF‐α), and IL‐6, considered as the main regulators of inflammation, leptin, more recently introduced, and several others, such as monocyte chemoattractant protein‐1, resistin, adiponectin, with either deleterious or beneficial effects in diabetic pathogenesis. The characterization of these molecules targeted diabetes treatment beyond the classical interventions with lifestyle changes and pharmaceutical agents, and toward the determination of specific molecular pathways that lead to low grade chronic inflammatory state mainly due to an immune system's unbalance.

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Authors: ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A.
Affiliations: National and Kapodistrian University of Athens (GR)
University of Lancashire (GB)
Corresponding author: PIPERI, CHRISTINA
ORCID: ALEXANDRAKI, KRYSTALLENIA
PIPERI, CHRISTINA
SINGH, JAIPAUL
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2006-11
Volume: 1084
Issue: 1
Pages: 89-117
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1372.039
OpenAlex: W1491280754
Semantic Scholar: 160271b5b2f5d455bde3b3b6558683292a30fa1c
Cited by: 309
References: 281
Citations by year: 2026: 7 · 2025: 9 · 2024: 21 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 11 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 14 · 2014: 22 · 2013: 20 · 2012: 14
FWCI: 2.18
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: type 2 diabetes, inflammation, adipose tissue macrophages, cytokines, IL-1β, TNF-α, interleukin-6, leptin, adiponectin, resistin, MCP-1, beta-cell apoptosis, obesity, atherosclerosis, low-grade inflammation, immune dysregulation
MeSH terms: Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Humans, Inflammation, Cytokines

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Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

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