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Cited by 309Adipokines, Inflammation, and Metabolic DiseasesDiabetes Treatment and ManagementAdipose Tissue and Metabolism

The DOI matches its Crossref record; 282 of the 282 references it cites were found in a registry or an index.

Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, KRYSTALLENIA, PIPERI, CHRISTINA, KALOFOUTIS, CHRISTOS, SINGH, JAIPAUL, ALAVERAS, ANTONIS, KALOFOUTIS, ANASTASIOS·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1372.039
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Abstract

Abstract: Population‐based studies have shown strong relationship between inflammatory markers and metabolic disturbances, obesity, and atherosclerosis, whereas inflammation has been considered as a “common soil” between these clinical entities and type 2 diabetes (T2D). The accumulation of macrophages in adipose tissue (AT), the common origin of macrophages and adipocytes, the prevalent presence of peripheral mononuclear cells, and apoptotic β cells by themselves seem to be the sources of inflammation present in T2D, since they generate the mediators of the inflammatory processes, namely cytokines. The main cytokines involved in the pathogenesis of T2D are interleukin‐1β (IL‐1β), with an action similar to the one present in type 1 diabetes, tumor necrosis factor‐α (TNF‐α), and IL‐6, considered as the main regulators of inflammation, leptin, more recently introduced, and several others, such as monocyte chemoattractant protein‐1, resistin, adiponectin, with either deleterious or beneficial effects in diabetic pathogenesis. The characterization of these molecules targeted diabetes treatment beyond the classical interventions with lifestyle changes and pharmaceutical agents, and toward the determination of specific molecular pathways that lead to low grade chronic inflammatory state mainly due to an immune system's unbalance.

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Crossref · 10.1196/annals.1372.039

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282 of 282 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 20

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Metadata

Authors
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • University of Lancashire (GB)
Corresponding author
PIPERI, CHRISTINA
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-11
Volume
1084
Issue
1
Pages
89-117
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1372.039
OpenAlex
W1491280754
Semantic Scholar
160271b5b2f5d455bde3b3b6558683292a30fa1c
Cited by
309
References
281
Citations by year
2026: 7 · 2025: 9 · 2024: 21 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 11 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 14 · 2014: 22 · 2013: 20 · 2012: 14
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 27 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
type 2 diabetes, inflammation, adipose tissue macrophages, cytokines, IL-1β, TNF-α, interleukin-6, leptin, adiponectin, resistin, MCP-1, beta-cell apoptosis, obesity, atherosclerosis, low-grade inflammation, immune dysregulation
MeSH terms
Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Humans, Inflammation, Cytokines

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