Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, KRYSTALLENIA, PIPERI, CHRISTINA, KALOFOUTIS, CHRISTOS, SINGH, JAIPAUL, ALAVERAS, ANTONIS, KALOFOUTIS, ANASTASIOS·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1372.039

Cites (281)

Items 201–282 of 282

  1. Leptin Is a Risk Marker for First-Ever Hemorrhagic Stroke in a Population-Based Cohort
    Stefan Söderberg, Bo Åhrén, Birgitta Stegmayr, Owe Johnson, Per-Gunnar Wiklund, Lars Weinehall, Göran Hallmans, Tommy Olsson · 1999 · Stroke
  2. Increased Expression of Membrane Type 3-Matrix Metalloproteinase in Human Atherosclerotic Plaque
    Hiroyasu Uzui, Alice E. Zemljic‐Harpf, Liu Ming, Terence M. Doherty, Arun Shukla, N. Chai, Pinky V. Tripathi, Stefan V. Jovinge, Douglas J. Wilkin, Kamlesh Asotra et al. · 2002 · Circulation
  3. Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone
    Colleen D. Russell, R. N. Petersen, Salome P. Rao, Matthew R. Ricci, A. Prasad, Y. Zhang, R E Brolin, Susan K. Fried · 1998 · American Journal of Physiology-Endocrinology and Metabolism
  4. Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells
    Yuko Funakoshi, Toshihiro Ichiki, Hiroaki Shimokawa, Kensuke Egashira, Kotaro Takeda, Kozo Kaibuchi, Motohiro Takeya, Teizo Yoshimura, Akira Takeshita · 2001 · Hypertension
  5. Cytotoxic Effects of Cytokines on Human Pancreatic Islet Cells in Monolayer Culture*
    Alexander Rabinovitch, WILMA SUMOSKI, Raymond V. Rajotte, Garth L. Warnock · 1990 · The Journal of Clinical Endocrinology & Metabolism
  6. Interleukin-6 and tumor necrosis factor-? are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    Andrew L. Carey, Clinton R. Bruce, Massimo Sacchetti, Mitchell J. Anderson, D.B. Olsen, Bengt Saltin, John Alan Hawley, Mark Anthony Febbraio · 2004 · Diabetologia
  7. Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis
    Călin D. Popa, M G Netea, Timothy R. D. J. Radstake, P L van Riel, P Barrera, J W M van der Meer · 2005 · Annals of the Rheumatic Diseases
  8. Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress
    ML Heiman · 1997 · Endocrinology
  9. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity
    Gina B. Di Gregorio, Lori L. Hensley, Tong Lü, Gouri Ranganathan, Philip A. Kern · 2004 · American Journal of Physiology-Endocrinology and Metabolism
  10. Leptin: an essential regulator of lipid metabolism
    Shannon P. Reidy, Jean‐Michel Weber · 2000 · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology
  11. Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes.
    Pietropaolo, M, Barinas-Mitchell, E, Pietropaolo, S L, Kuller, L H, Trucco, M · 2000 · Diabetes
  12. Hyperleptinaemia: the Missing Link in the Metabolic Syndrome?
    Maximilian de Courten, Paul Zimmet, Allison M. Hodge, V. Collins, Margery A. Nicolson, Myrlene A. Staten, Gary K. Dowse, K. G. M. M. Alberti · 1997 · Diabetic Medicine
  13. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
    Nick Giannoukakis, William A. Rudert, Steven C. Ghivizzani, Andrea A. Gambotto, Camillo Ricordi, Massimo Trucco, Paul D. Robbins · 1999 · Diabetes
  14. Vascular and Metabolic Effects of Combined Therapy With Ramipril and Simvastatin in Patients With Type 2 Diabetes
    Kwang Kon Koh, Michael J. Quon, Seung Hwan Han, Jeong Yeal Ahn, Dong‐Kyu Jin, Hyung Sik Kim, Dae Sung Kim, Eak Kyun Shin · 2005 · Hypertension
  15. Elevated serum leptin concentrations induced by experimental acute inflammation
    Oreste Gualillo, Sonia Eiras-Penas, Francisca Lago, Carlos Diéguez, Felipe F. Casanueva · 2000 · Life Sciences
  16. Regional differences in protein production by human adipose tissue
    Peter Arner · 2001 · Biochemical Society Transactions
  17. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2(cPLA2γ) protein expression
    Peter Mancuso, Claudio de Azevedo Canetti, Andrew Gottschalk, Patricia K. Tithof, Marc L. Peters-Golden · 2004 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  18. Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets
    Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A. Zuellig, Giatgen A. Spinas, Per O. G. Arkhammar, Thomas R Mandrup-Poulsen, Marc Yves Donath · 2004 · Diabetes
  19. Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist
    Frank Peelman, Katrien Van Beneden, Lennart Zabeau, Hannes Iserentant, Peter Ulrichts, Delphine Defeau, Annick Verhee, Dominiek Catteeuw, Dirk Sw Elewaut, Jan H. Tavernier · 2004 · Journal of Biological Chemistry
  20. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation.
    Anne C. Loweth, Gwyn T. Williams, Roger F.L. James, John H.B. Scarpello, Noel G. Morgan · 1998 · Diabetes
  21. Diabesity: An Inflammatory Metabolic Condition
    María Inês Schmidt, Bruce Bartholow Duncan · 2003 · Clinical Chemistry and Laboratory Medicine (CCLM)
  22. Interleukin-6 and insulin sensitivity: friend or foe?
    Andrew L. Carey, Mark Anthony Febbraio · 2004 · Diabetologia
  23. IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo.
    Seung-eun Choi, Kyung-Mi Choi, I. Yoon, Jin-Young Shin, Jung-Sik Kim, W. Park, D. Han, Song-Chul Kim, C. Ahn, Jae-Young Kim et al. · 2004 · Transplant Immunology
  24. Inflammation, insulin resistance, and obesity
    Patrizia Ferroni, Stefania Basili, Angela Falco, Giovanni Davı̀ · 2004 · Current Atherosclerosis Reports
  25. FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
    Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas et al. · 2002 · Proceedings of the National Academy of Sciences
  26. Leptin Induces Proliferation of Pancreatic β Cell Line MIN6 through Activation of Mitogen-Activated Protein Kinase
    Katsuya Tanabe, Shigeru Okuya, Yukio Tanizawa, Akira Matsutani, Yoshitomo Oka · 1997 · Biochemical and Biophysical Research Communications
  27. Interleukin 1β and interleukin 6, but not tumor necrosis factor α, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes
    Toshiki Kanemaki, Hiroaki Kitade, Masaki Kaibori, Kazushige Sakitani, 義文 平松, Yasuo Kamiyama, Seiji Ito, Tadayoshi Okumura · 1998 · Hepatology
  28. Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules
    C Weber, Emil V. Negrescu, Wolfgang Erl, Angelika Pietsch, Marion Frankenberger, H.W.L. Ziegler-Heitbrock, Wolfgang Siess, P C Weber · 1995 · The Journal of Immunology
  29. Interleukin-6 Affects Insulin Secretion and Glucose Metabolism of Rat Pancreatic Isletsin Vitro*
    Stellan Sandler, Klaus Bendtzen, Decio Laks Eizirik, Michael Welsh · 1990 · Endocrinology
  30. The Potential Influence of Inflammation and Insulin Resistance on the Pathogenesis and Treatment of Atherosclerosis-Related Complications in Type 2 Diabetes
    Paresh Dandona, Ahmad Aljada, Ajay Chaudhuri, Arindam Bandyopadhyay · 2003 · The Journal of Clinical Endocrinology & Metabolism
  31. Serum Levels of Tumor Necrosis Factor- Are Increased in Obese Patients with Noninsulin-Dependent Diabetes Mellitus
    Akira Katsuki · 1998 · The Journal of Clinical Endocrinology & Metabolism
  32. Inflammation and Insulin Resistance
    Zachary T. Bloomgarden · 2003 · Diabetes Care
  33. Evidence for IL-6 production by and effects on the pancreatic beta-cell.
    Iain Leslie Campbell, A Cutri, A Wilson, Leonard C. Harrison · 1989 · The Journal of Immunology
  34. A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis
    Paresh Dandona, Ahmad Aljada · 2002 · The American Journal of Cardiology
  35. Interleukin-6 Enhances Glucose Transport in 3T3-L1 Adipocytes
    J.M.L. Stouthard, Ronald P.J. Oude Elferink, Hans P. Sauerwein · 1996 · Biochemical and Biophysical Research Communications
  36. White Adipose Tissue: Getting Nervous
    Fliers, E., Kreier, F., Voshol, P. J., Havekes, L. M., Sauerwein, H. P., Kalsbeek, A., Buijs, R. M., Romijn, J. A. · 2003 · Journal of Neuroendocrinology
  37. Leptin potentiates IFN‐γ‐induced expression of nitric oxide synthase and cyclo‐oxygenase‐2 in murine macrophage J774A.1
    Giuseppina Mattace Raso, Maria Pacilio, Emanuela Esposito, Anna M. Coppola, Raffaele Di Carlo, Rosaria Meli · 2002 · British Journal of Pharmacology
  38. Effects of estrogen on the vascular wall: vasomotor function and inflammation
    Kwang Kon Koh · 2002 · Cardiovascular Research
  39. Tumour necrosis factor-α exerts dual effects on human adipose leptin synthesis and release
    Huihui Zhang, Sudhesh Kumar, Anthony H Barnett, Margaret C. Eggo · 2000 · Molecular and Cellular Endocrinology
  40. Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases
    Frank Peelman, Wim Waelput, Hannes Iserentant, Delphine Lavens, Sven Eyckerman, Lennart Zabeau, Jan H. Tavernier · 2004 · Progress in Lipid Research
  41. Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events
    José L. Torres, Paul M. Ridker · 2003 · Current Opinion in Cardiology
  42. Leptin and Leptin Receptor Expression in Normal and Neoplastic Human Pituitary: Evidence of a Regulatory Role for Leptin on Pituitary Cell Proliferation
    L. Jin · 1999 · The Journal of Clinical Endocrinology & Metabolism
  43. Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome
    Kenji Ueki, T KADOWAKI, C. Ronald Kahn · 2005 · Hepatology Research
  44. Chronic activation of the innate immune system may underlie the metabolic syndrome
    Bruce Bartholow Duncan, María Inês Schmidt · 2001 · Sao Paulo Medical Journal
  45. β-Cells in Type 2 Diabetes: A Loss of Function and Mass
    Kathrin Maedler, M.Y. Donath · 2004 · Hormone Research in Paediatrics
  46. The Union of Vascular and Metabolic Actions of Insulin in Sickness and in Health
    Jeong‐a Kim, Kwang Kon Koh, Michael J. Quon · 2005 · Arteriosclerosis Thrombosis and Vascular Biology
  47. Suppression of Nuclear Factor- B and Stimulation of Inhibitor B by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese
    Husam Ghanim · 2001 · The Journal of Clinical Endocrinology & Metabolism
  48. The dysregulated adipose tissue: A connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis
    Giuseppe Murdolo, Ulf Smith · 2006 · Nutrition Metabolism and Cardiovascular Diseases
  49. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice.
    Iain Leslie Campbell, M V Hobbs, Janel Dockter, Michael B. A. Oldstone, J Allison · 1994 · PubMed Central
  50. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits
    Kiyoshi Matsumura, Isao Abe, Takuya Tsuchihashi, Masatoshi Fujishima · 2000 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  51. Neural regulation of blood pressure by leptin and the related peptides
    Kiyoshi Matsumura, Takuya Tsuchihashi, Koji Fujii, Mitsuo Iida · 2003 · Regulatory Peptides
  52. Leptin Induces Growth Hormone Secretion from Peripheral Blood Mononuclear Cells via a Protein Kinase C- and Nitric Oxide-Dependent Mechanism
    Vishwa Deep Dixit, M. Mielenz, Dennis Daniel Taub, Nahid Parvizi · 2003 · Endocrinology
  53. Statin Attenuates Increase in C-Reactive Protein During Estrogen Replacement Therapy in Postmenopausal Women
    Kwang Kon Koh, William H. Schenke, Myron A. Waclawiw, György Csákó, Richard O. Cannon · 2002 · Circulation
  54. The role of interleukin-6 in lipopolysaccharide-induced weight loss, hypoglycemia and fibrinogen production, in vivo
    Gideon Strassmann, Miranda Fong, S Windsor, Ruth Neta · 1993 · Cytokine
  55. Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF- -Mediated Insulin Resistance in Genetic Obesity
    K. T. Uysal · 1998 · Endocrinology
  56. Leptin Increases the Viability of Isolated Rat Pancreatic Islets by Suppressing Apoptosis
    Shigeru Okuya, Katsuya Tanabe, Yukio Tanizawa, Yoshitomo Oka · 2001 · Endocrinology
  57. Leptin down-regulates the steroid producing system in the adrenal
    Michael Kruse, SR Bornstein, K. Uhlmann, G. Paeth, Werner Alfons Scherbaum · 1998 · Endocrine Research
  58. Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids
    Philippe Cammisotto, Yves Gélinas, Yves Deshaies, Ludwik Jan Bukowiecki · 2005 · American Journal of Physiology-Endocrinology and Metabolism
  59. -Adrenergic Regulation of IL-6 Release from Adipose Tissue: In Vivo and in Vitro Studies
    Vidya Mohamed‐Ali · 2001 · The Journal of Clinical Endocrinology & Metabolism
  60. Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6. An effect distinct from that of interleukin-1
    C. Southern, Dennis Schulster, Irene C. Green · 1990 · Biochemical Journal
  61. Cellular inflammatory responses: Novel insights for obesity and insulin resistance
    Hong Chen · 2006 · Pharmacological Research
  62. Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells
    Md. Shahidul Islam, Åke Sjöholm, Valur Emilsson · 2000 · International Journal of Obesity
  63. Nuclear Factor- B Suppressive and Inhibitor- B Stimulatory Effects of Troglitazone in Obese Patients with Type 2 Diabetes: Evidence of an Antiinflammatory Action?
    Ahmad Aljada · 2001 · The Journal of Clinical Endocrinology & Metabolism
  64. Initiation of insulin therapy reduces serum concentrations of high-sensitivity C-reactive protein in patients with type 2 diabetes
    Kohzo Takebayashi, Yoshimasa Aso, Toshihiko Inukai · 2004 · Metabolism
  65. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice
    Bruno DiCosmo, Dominic Picarella, Richard A. Ravell · 1994 · International Immunology
  66. Tumor necrosis factor-α-induced leukocyte adhesion and microvessel permeability
    Min Zeng, Hong Zhang, Clifford A. Lowell, Pingnian He · 2002 · American Journal of Physiology-Heart and Circulatory Physiology
  67. Effects of tumour necrosis factor-α in the human forearm: blood flow and endothelin-1 release
    Jigisha Patel, A. JAGER, Caspar Schalkwijk, Roger Corder, Julie A. Douthwaite, John S Yudkin, Simon W. Coppack, Coen D.A. Stehouwer · 2002 · Clinical Science
  68. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase.
    Karin Wadt, Claus Morten Larsen, Henrik Ullits Andersen, K Nielsen, Allan Ertmann Karlsen, Thomas R Mandrup-Poulsen · 1998 · Diabetes
  69. Lowered Tumor Necrosis Factor Receptors, but Not Increased Insulin Sensitivity, with Infliximab
    Paola Di Rocco, Melania Manco, Giuseppina Rosa, Aldo Virgilio Greco, Geltrude Mingrone · 2004 · Obesity Research
  70. Inhibition of Tumor Necrosis Factor α-mediated NFκB Activation and Leukocyte Adhesion, with Enhanced Endothelial Apoptosis, by G Protein-linked Receptor (TP) Ligands
    Anthony W. Ashton, Gabriel M. Ware, Dhananjaya K. Kaul, J. Anthony Ware · 2003 · Journal of Biological Chemistry
  71. T lymphopenia in obese diabetic () mice is non-selective and thymus independent
    Mari Kimura, Shun'ichi Tanaka, Fumiko Isoda, Kenichiro Sekigawa, Tadashi Yamakawa, Hisahiko Sekihara · 1998 · Life Sciences
  72. Simvastatin Combined With Ramipril Treatment in Hypercholesterolemic Patients
    Koh, Kwang Kon, Son, Ji Won, Ahn, Jeong Yeal, Kim, Dae Sung, Jin, Dong Kyu, Kim, Hyung Sik, Han, Seung Hwan, Seo, Yiel-Hea, Chung, Wook-Jin, Kang, Woong Chol et al. · 2004 · Hypertension
  73. Troglitazone reduces plasma levels of tumour necrosis factor‐α in obese patients with type 2 diabetes
    Akira Katsuki, Yasuhiro Sumida, Kazuya Murata, Masahiko Furuta, Rika Araki-Sasaki, Ken Tsuchihashi, Yasuko Hori, Yutaka Yano, Esteban Cesar Gabazza, Yukihiko Adachi · 2000 · Diabetes Obesity and Metabolism
  74. The therapeutic potential of interleukin-6 in treating obesity
    Kristina Wallenius, John‐Olov Jansson, Ville Wallenius · 2003 · Expert Opinion on Biological Therapy
  75. Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes
    Hideaki Kaneto, Dan Kawamori, Y. Nakatani, Shin-ichi Gorogawa, T. Matsuoka · 2004 · Drug News & Perspectives
  76. Relationship of C-reactive protein with components of the metabolic syndrome in normal-weight and overweight elderly
    Tiny Hoekstra, Johanna Marianne Geleijnse, Evert G. Schouten, Frans J. Kok, Cornelis Kluft · 2005 · Nutrition Metabolism and Cardiovascular Diseases
  77. Prevention of Type 2 Diabetes: Issues and Strategies for Identifying Persons for Interventions
    Michael Maurice Engelgau, Stephen Colagiuri, Ambady Ramachandran, Knut Borch‐Johnsen, K.M. Venkat Narayan · 2004 · Diabetes Technology & Therapeutics
  78. Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice
    Terence T. T. Yen, Jean A. Allan, Donovan V. Pearson, M. R. Schinitsky · 1977 · Cellular and Molecular Life Sciences
  79. Fatty acids potentiate interleukin-1β toxicity in the β-cell line INS-1E
    M Aarnes, Svanhild Arentz Schønberg, Valdemar Grill · 2002 · Biochemical and Biophysical Research Communications
  80. Comparative effects of diet and simvastatin on markers of thrombogenicity in patients with coronary artery disease
    Kwang Kon Koh, Ji Won Son, Jeong Yeal Ahn, Dae Sung Kim, Seung Hwan Han, Tae Hoon Ahn, In Suck Choi, Gi Soo Park, Eak Kyun Shin · 2003 · The American Journal of Cardiology
  81. Diabetes and Atherothrombotic Disease: Linked through Inflammation?
    Russell P. Tracy · 2002 · Seminars in Vascular Medicine
  82. Cystic Adventitial Disease of the Popliteal Artery
    Renate Koppensteiner, Reinhold Katzenschlager, Reinhart Horvat, Ali Ahmadi, Michael Staudacher, Peter Polterauer, H Ehringer · 1997 · Vascular Medicine