The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Risk, Resilience, and Gene × Environment Interactions in Rhesus Monkeys
Abstract
Abstract: Recent research with both humans and rhesus monkeys has provided compelling evidence of gene–environment (GxE) interactions throughout development. For example, a specific polymorphism (“short” allele) in the promoter region of the serotonin transporter (5‐HTT) gene is associated with deficits in neurobehavioral functioning during infancy and in poor control of aggression and low serotonin metabolism throughout juvenile and adolescent development in monkeys who were reared with peers but not in monkeys who were reared with their mothers and peers during infancy. In contrast, monkeys possessing the “long” allele of the 5‐HTT gene exhibit normal neurobehavioral functioning, control of aggression, and serotonin metabolism regardless of their early social rearing history. One interpretation of these GxE interaction data is that the “long” 5‐HTT allele somehow confers resiliency to adverse early attachment relationships on those individuals who carry it (“good genes”). An alternative interpretation of the same data is that secure attachment relationships somehow confer resiliency to individuals who carry alleles that may otherwise increase their risk for adverse developmental outcomes (“maternal buffering”). These two interpretations are not mutually exclusive, but the difference in their respective implications for developing prevention and even intervention strategies is considerable. Moreover, the allelic variation seen in certain genes in rhesus monkeys and humans but apparently not in other primate species may actually contribute to their remarkable adaptability and resilience at the species level.
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“polymorphisms in the promoter region of the SERT gene have been associated both with a functional change in the transporter capacity and with individual variation in aggression and personality in humans and in rhesus monkeys”
From Coping styles and behavioural flexibility: towards underlying mechanisms (2010) · cites this paper as Suomi 2006
In the citing paper
“polymorphisms in the promoter region of the SERT gene have been associated both with a functional change in the transporter capacity and with individual variation in aggression and personality in humans and in rhesus monkeys”
From Coping styles and behavioural flexibility: towards underlying mechanisms (2010) · cites this paper as Suomi 2006
Citations
Cites
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Self-citationCerebrospinal Fluid Monoamine and Adrenal Correlates of Aggression in Free-Ranging Rhesus Monkeys
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Self-citationSuomi, S. J. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0055 · Cited by 182
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Self-citationDominance Style Among Macaca thibetana on Mt. Huangshan, China
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Self-citationA Biobehavioral Perspective on Developmental Psychopathology
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Self-citationHow Gene–Environment Interactions Shape the Development of Impulsive Aggression in Rhesus Monkeys
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Self-citation
Research works printed but not linked: 10
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Cited by
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200
Neurobiological and Systemic Effects of Chronic Stress
McEwen, B. S. (2017) · Chronic Stress · doi:10.1177/2470547017692328 · Cited by 1,059
Vulnerability genes or plasticity genes?
Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.44 · Cited by 1,017
Metadata
- Authors
- SUOMI, S. J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2006-12
- Volume
- 1094
- Issue
- 1
- Pages
- 52-62
- ISSN
- 0077-8923
- 1749-6632
- Cited by
- 198
- References
- 29
- Language
- en
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