Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 198

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Risk, Resilience, and Gene × Environment Interactions in Rhesus Monkeys

SUOMI, STEPHEN J.·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1376.006
Open this paper in CoChat — free account

Abstract

Abstract: Recent research with both humans and rhesus monkeys has provided compelling evidence of gene–environment (GxE) interactions throughout development. For example, a specific polymorphism (“short” allele) in the promoter region of the serotonin transporter (5‐HTT) gene is associated with deficits in neurobehavioral functioning during infancy and in poor control of aggression and low serotonin metabolism throughout juvenile and adolescent development in monkeys who were reared with peers but not in monkeys who were reared with their mothers and peers during infancy. In contrast, monkeys possessing the “long” allele of the 5‐HTT gene exhibit normal neurobehavioral functioning, control of aggression, and serotonin metabolism regardless of their early social rearing history. One interpretation of these GxE interaction data is that the “long” 5‐HTT allele somehow confers resiliency to adverse early attachment relationships on those individuals who carry it (“good genes”). An alternative interpretation of the same data is that secure attachment relationships somehow confer resiliency to individuals who carry alleles that may otherwise increase their risk for adverse developmental outcomes (“maternal buffering”). These two interpretations are not mutually exclusive, but the difference in their respective implications for developing prevention and even intervention strategies is considerable. Moreover, the allelic variation seen in certain genes in rhesus monkeys and humans but apparently not in other primate species may actually contribute to their remarkable adaptability and resilience at the species level.

Overview

Integrity signals

Registry

Crossref · 10.1196/annals.1376.006

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 29 references

Research works printed but not linked: 10

  1. Suomi S.J., 1991, Primate separation models of affective disorders, Neurobiology of Learning, Emotion, and Affect., 195
  2. Scanlan J.S.1988.Continuity of stress responsivity in infant monkeys (Macacamulatta): state hormonal dominance and genetic status.Ph.D. thesis University of Wisconsin Madison WI .
  3. Suomi S.J., 2000, Op. cit
  4. Suomi S.J., 1999, Op. cit
  5. Suomi S.J., 2000, Op. cit
  6. Higley J.D., 1992, op. cit
  7. Higley J.D., 1991, Op. cit.
  8. Bennett A.J., 1998, Serotonin transporter gene variation, CSF 5‐HIAA concentrations, and alcohol‐related aggression in rhesus monkeys (Macaca mulatta), Am. J. Primatol., 45, 168
  9. Caspi A., 2003, Op. cit
  10. Thierry B, 2000, Covaration of conflict management patterns across macaque species, Natural Conflict Resolution., 106

Cited by

Metadata

Authors
SUOMI, S. J.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-12
Volume
1094
Issue
1
Pages
52-62
ISSN
  • 0077-8923
  • 1749-6632
DOI
10.1196/annals.1376.006
Cited by
198
References
29
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 77 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.