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Cited by 361Nerve injury and regenerationNeurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Brain‐Derived Neurotrophic Factor in Neuronal Survival and Behavior‐Related Plasticity

LIPSKY, ROBERT H., MARINI, ANN M.·2007·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1403.009
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Abstract

Neurotrophins are critical to the development and maintenance of the mammalian central nervous system. Among them is brain‐derived neurotrophic factor (BDNF), whose synthesis and release is targeted by activation of glutamate receptors. Perturbation of this process probably underlies neurodegenerative and psychiatric disorders. A naturally occurring variation in humans, in the form of a common single‐nucleotide polymorphism in the pro region of the polypeptide at codon 66 (Val66→Met), affects processing of the pro‐BDNF polypeptide and its activation‐dependent release. This variant is associated with differences in the volume of the hippocampal formation and with anxiety and depression‐related phenotypes. Convergent findings supporting a role for BDNF in alterations to hippocampal structure and behavior are found in a “humanized” BDNF transgenic mouse. Also, recent human genetic studies have supported a role of BDNF signaling in addictive behaviors by allele‐, genotype‐, and haplotype‐based association of the TrkB gene, which encodes the cognate receptor for BDNF, with alcohol dependence. A better understanding of the influence of BDNF‐mediated pathways in cell survival and plasticity will aid in developing new approaches to restoring normal function in disease states.

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Crossref · 10.1196/annals.1403.009

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Metadata

Authors
LIPSKY, R. H., & MARINI, A. M.
Affiliations
National Institutes of Health (US)
Corresponding author
MARINI, ANN M.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2007-12
Volume
1122
Issue
1
Pages
130-143
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1403.009
OpenAlex
W2060545591
Cited by
361
References
85
Citations by year
2026: 4 · 2025: 18 · 2024: 13 · 2023: 18 · 2022: 22 · 2021: 15 · 2020: 27 · 2019: 23 · 2018: 18 · 2017: 26 · 2016: 16 · 2015: 31 · 2014: 32 · 2013: 20 · 2012: 28
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
brain-derived neurotrophic factor, neurotrophins, neuronal survival, synaptic plasticity, BDNF Val66Met polymorphism, glutamate receptor activation, hippocampal volume, anxiety, depression, TrkB receptor, alcoholism, addictive behavior, neurodegenerative diseases, mental illness
MeSH terms
Behavioral Symptoms, Cell Survival, Humans, Memory, Mutation, Neuronal Plasticity, Neurons, Brain-Derived Neurotrophic Factor

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