Cited by 361Nerve injury and regenerationNeurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

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Brain‐Derived Neurotrophic Factor in Neuronal Survival and Behavior‐Related Plasticity

LIPSKY, ROBERT H., MARINI, ANN M.·2007·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1403.009

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Abstract

Neurotrophins are critical to the development and maintenance of the mammalian central nervous system. Among them is brain‐derived neurotrophic factor (BDNF), whose synthesis and release is targeted by activation of glutamate receptors. Perturbation of this process probably underlies neurodegenerative and psychiatric disorders. A naturally occurring variation in humans, in the form of a common single‐nucleotide polymorphism in the pro region of the polypeptide at codon 66 (Val66→Met), affects processing of the pro‐BDNF polypeptide and its activation‐dependent release. This variant is associated with differences in the volume of the hippocampal formation and with anxiety and depression‐related phenotypes. Convergent findings supporting a role for BDNF in alterations to hippocampal structure and behavior are found in a “humanized” BDNF transgenic mouse. Also, recent human genetic studies have supported a role of BDNF signaling in addictive behaviors by allele‐, genotype‐, and haplotype‐based association of the TrkB gene, which encodes the cognate receptor for BDNF, with alcohol dependence. A better understanding of the influence of BDNF‐mediated pathways in cell survival and plasticity will aid in developing new approaches to restoring normal function in disease states.

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Authors: LIPSKY, R. H., & MARINI, A. M.
Affiliations: National Institutes of Health (US)
Corresponding author: MARINI, ANN M.
ORCID: LIPSKY, ROBERT H.
MARINI, ANN M.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2007-12
Volume: 1122
Issue: 1
Pages: 130-143
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1403.009
OpenAlex: W2060545591
Cited by: 361
References: 85
Citations by year: 2026: 4 · 2025: 18 · 2024: 13 · 2023: 18 · 2022: 22 · 2021: 15 · 2020: 27 · 2019: 23 · 2018: 18 · 2017: 26 · 2016: 16 · 2015: 31 · 2014: 32 · 2013: 20 · 2012: 28
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, neurotrophins, neuronal survival, synaptic plasticity, BDNF Val66Met polymorphism, glutamate receptor activation, hippocampal volume, anxiety, depression, TrkB receptor, alcoholism, addictive behavior, neurodegenerative diseases, mental illness
MeSH terms: Behavioral Symptoms, Cell Survival, Humans, Memory, Mutation, Neuronal Plasticity, Neurons, Brain-Derived Neurotrophic Factor

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Brain‐Derived Neurotrophic Factor in Neuronal Survival and Behavior‐Related Plasticity

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