Neurotrophin signalling: novel insights into mechanisms and pathophysiology

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

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The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

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An anatomically comprehensive atlas of the adult human brain transcriptome

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Neurotrophin regulation of neural circuit development and function

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Neurotrophins and Neuronal Plasticity

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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

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Regulation of Cell Survival by Secreted Proneurotrophins

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Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

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Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,319 · see citing works

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

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Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

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ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTRand Sortilin

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Sortilin is essential for proNGF-induced neuronal cell death

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BDNF - a key transducer of antidepressant effects

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Brain-derived neurotrophic factor in neurodegenerative diseases

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Anterograde transport of brain-derived neurotrophic factor and its role in the brain

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

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p75 and Trk: A two-receptor system

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Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)

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trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

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Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

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Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects

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Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

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Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

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Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression

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Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume.

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The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works

Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo

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Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

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Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

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Role of brain-derived neurotrophic factor in Huntington's disease

Zuccato, C., & Cattaneo, E. F. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.003 · Cited by 548 · see citing works

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533 · see citing works

Region-Specific Neurotrophin Imbalances in Alzheimer Disease: Decreased Levels of Brain-Derived Neurotrophic Factor and Increased Levels of Nerve Growth Factor in Hippocampus and Cortical Areas

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Activation of Trk neurotrophin receptors in the absence of neurotrophins

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Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

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Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice

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A controlled trial of recombinant methionyl human BDNF in ALS

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Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

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Early Striatal Dendrite Deficits followed by Neuron Loss with Advanced Age in the Absence of Anterograde Cortical Brain-Derived Neurotrophic Factor

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Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression

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Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

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Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

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Relationship of Brain-Derived Neurotrophic Factor and Its Receptor TrkB to Altered Inhibitory Prefrontal Circuitry in Schizophrenia

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BDNF release is required for the behavioral actions of ketamine

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Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

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Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

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Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits

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Retrograde neurotrophin signaling: Trk-ing along the axon

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Reduced expression of brain-derived neurotrophic factor protein in Parkinsonʼs disease substantia nigra

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Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

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Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

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Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N -methyl- d -aspartate receptor subunit 1

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Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia: The Framingham Heart Study

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Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

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BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities

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Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse

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BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus

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Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease

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The Cytoplasmic and Transmembrane Domains of the p75 and Trk A Receptors Regulate High Affinity Binding to Nerve Growth Factor

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RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's Disease

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Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimerʼs disease

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Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

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Expression Profiling of Huntington's Disease Models Suggests That Brain-Derived Neurotrophic Factor Depletion Plays a Major Role in Striatal Degeneration

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The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

Pucilowska, J., Vithayathil, J., Tavares, E. J., Kelly, C., Karlo, J. C., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4864-13.2015 · Cited by 207 · see citing works

Activation of Trk Neurotrophin Receptor Signaling by Pituitary Adenylate Cyclase-activating Polypeptides

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Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia

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Delving deeper into resistance

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Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

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Retrograde axonal transport of specific macromolecules as a tool for characterizing nerve terminal membranes

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Growth Control of Nerve Cells by a Protein Factor and Its Antiserum

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An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease

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Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice

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Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

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The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching

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Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications

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Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

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