Cited by 847Mitochondrial Function and PathologyRedox biology and oxidative stressAutophagy in Disease and Therapy

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The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

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Starkov, Anatoly A.·2008·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1427.015PMC PMC2869479

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Abstract

Oxidative stress is considered a major contributor to the etiology of both “normal” senescence and severe pathologies with serious public health implications. Several cellular sources, including mitochondria, are known to produce significant amounts of reactive oxygen species (ROS) that may contribute to intracellular oxidative stress. Mitochondria possess at least 10 known sites that are capable of generating ROS, but they also feature a sophisticated multilayered ROS defense system that is much less studied. This review summarizes the current knowledge about major components involved in mitochondrial ROS metabolism and factors that regulate ROS generation and removal at the level of mitochondria. An integrative systemic approach is applied to analysis of mitochondrial ROS metabolism, which is “dissected” into ROS generation, ROS emission, and ROS scavenging. The in vitro ROS‐producing capacity of several mitochondrial sites is compared in the metabolic context and the role of mitochondria in ROS‐dependent intracellular signaling is discussed.

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10.1172/JCI200524408 · DOI
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Authors: Starkov, A. A.
Affiliations: Cornell University (US)
Corresponding author: Starkov, Anatoly A.
ORCID: Starkov, Anatoly A.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2008-12
Volume: 1147
Issue: 1
Pages: 37-52
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1427.015
PMC: PMC2869479
OpenAlex: W2053022803
Cited by: 846
References: 86
Citations by year: 2026: 39 · 2025: 39 · 2024: 42 · 2023: 66 · 2022: 67 · 2021: 78 · 2020: 74 · 2019: 55 · 2018: 42 · 2017: 46 · 2016: 50 · 2015: 39 · 2014: 38 · 2013: 41 · 2012: 39
FWCI: 2.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG014930, P01AG014930)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondria, reactive oxygen species, oxidative stress, ROS signaling, reactive oxygen species scavenging, aging, cellular senescence
MeSH terms: Humans, Mitochondria, Signal Transduction, Reactive Oxygen Species, Oxidative Stress

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The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

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