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Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial.
Abstract
To determine the role of chemotherapy in the multidisciplinary treatment of patients with osteosarcoma, a randomized prospective trial of postoperative adjuvant chemotherapy was begun in 1981. Fifty-nine patients with nonmetastatic classic intramedullary osteosarcoma were randomized; 32 received postoperative adjuvant chemotherapy consisting of high-dose methotrexate, Adriamycin (Adria Laboratories, Columbus, OH), and BCD (bleomycin, cytoxan, actinomycin D), and 27 patients received no adjuvant chemotherapy. At a median follow-up of 2 years, there was a statistically significant improvement in both disease-free and overall survival in those who received adjuvant chemotherapy. In addition, there was no difference in the less than 20% disease-free or overall survival of patients treated in the 1970s who did not receive chemotherapy, as compared with the concurrent nontreatment controls. Therefore, with identical staging procedures, uniform surgical management, and standard pathologic evaluation, postoperative adjuvant chemotherapy definitely improves disease-free and overall survival in patients with osteosarcoma.
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Metadata
- Authors
- Eilber, F., Giuliano, A., Eckardt, J., Patterson, K., Moseley, S., & Goodnight, J.
- Venue
- Journal of Clinical Oncology
- Published
- 1987-01
- Volume
- 5
- Issue
- 1
- Pages
- 21-26
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2164650822
- Cited by
- 529
- References
- 0
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eilber, F., Giuliano, A., Eckardt, J., Patterson, K., Moseley, S., & Goodnight, J. (1987). Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1987.5.1.21
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
