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Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases.
Abstract
PURPOSE AND METHODS: This study assessed the relationship between survival, tumor size, and quality of life (QoL; Rotterdam Symptom Checklist [RSC], Hospital Anxiety and Depression Scale [HAD], and Sickness Impact Profile [SIP]) in 50 patients with colorectal liver metastases (CLM). RESULTS: Physical symptom score (RSC) was a stronger survival predictor than tumor size measured on computed tomographic (CT) scan. The best model for predicting survival included QoL questions about diarrhea, eating, restlessness, and ability to work and sleep. The only clinically measured variable included in this best survival prediction model was serum alkaline phosphatase level. This is the first study to show that QoL indices predict survival in CLM. The findings suggest that differences in tumor products and not just in tumor size could influence patient fitness and survival in CLM. Such differences are more accurately estimated by QoL assessment than measurement of tumor size. CONCLUSION: QoL provides a better survival estimate than measurement of tumor size and could be used as a surrogate end point for survival in treatment trials.
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Cited by
Cunningham, D., Pyrhönen, S., James, R. D., Punt, C. J., Hickish, T. F., Heikkila, R., Johannesen, T. B., Starkhammar, H., Topham, C. A., Awad, L., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02309-5 · Cited by 1,259
Predicting survival in patients with advanced disease
Glare, P., Sinclair, C., Downing, M., Stone, P., Maltoni, M., & Vigano, A. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.030 · Cited by 277
Comer, J. S., Blanco, C., Hasin, D. S., Liu, S.-M., Grant, B. F., Turner, J. B., & Olfson, M. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05094blu · Cited by 214
Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer
de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., Hordijk, G. J., Blijham, G. H., & Winnubst, J. A. M. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00385-3 · Cited by 199
Metadata
- Authors
- Earlam, S., Glover, C., Fordy, C., Burke, D., & Allen-Mersh, T. G.
- Venue
- Journal of Clinical Oncology
- Published
- 1996-01
- Volume
- 14
- Issue
- 1
- Pages
- 171-175
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1942333916
- Cited by
- 178
- References
- 0
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases. https://app.cochat.ai/papers/10.1200/jco.1996.14.1.171
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- Earlam, S., Glover, C., Fordy, C., Burke, D., & Allen-Mersh, T. G. (1996). Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1996.14.1.171
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
