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Cited by 265

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Systemic Therapy for Melanoma: ASCO Guideline

Seth, Rahul, Messersmith, Hans, Kaur, Varinder, Kirkwood, John M., Kudchadkar, Ragini, McQuade, Jennifer Leigh, Provenzano, Anthony, Swami, Umang, Weber, Jeffrey, Alluri, Krishna C., Agarwala, Sanjiv, Ascierto, Paolo A., Atkins, Michael B., Davis, Nancy, Ernstoff, Marc S., Faries, Mark B., Gold, Jason S., Guild, Samantha, Gyorki, David E., Khushalani, Nikhil I., Meyers, Michael O., Robert, Caroline, Santinami, Mario, Sehdev, Amikar, Sondak, Vernon K., Spurrier, Gilliosa, Tsai, Katy K., van Akkooi, Alexander, Funchain, Pauline·2020·Journal of Clinical Oncology
DOI 10.1200/jco.20.00198
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Abstract

PURPOSE: To provide guidance to clinicians regarding the use of systemic therapy for melanoma. METHODS: ASCO convened an Expert Panel and conducted a systematic review of the literature. RESULTS: A systematic review, one meta-analysis, and 34 additional randomized trials were identified. The published studies included a wide range of systemic therapies in cutaneous and noncutaneous melanoma. RECOMMENDATIONS: In the adjuvant setting, nivolumab or pembrolizumab should be offered to patients with resected stage IIIA/B/C/D BRAF wild-type cutaneous melanoma, while either of those two agents or the combination of dabrafenib and trametinib should be offered in BRAF-mutant disease. No recommendation could be made for or against the use of neoadjuvant therapy in cutaneous melanoma. In the unresectable/metastatic setting, ipilimumab plus nivolumab, nivolumab alone, or pembrolizumab alone should be offered to patients with BRAF wild-type cutaneous melanoma, while those three regimens or combination BRAF/MEK inhibitor therapy with dabrafenib/trametinib, encorafenib/binimetinib, or vemurafenib/cobimetinib should be offered in BRAF-mutant disease. Patients with mucosal melanoma may be offered the same therapies recommended for cutaneous melanoma. No recommendation could be made for or against specific therapy for uveal melanoma. Additional information is available at www.asco.org/melanoma-guidelines .

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Metadata

Authors
Seth, R., Messersmith, H., Kaur, V., Kirkwood, J. M., Kudchadkar, R., McQuade, J. L., Provenzano, A., Swami, U., Weber, J., Alluri, K. C., Agarwala, S., Ascierto, P. A., Atkins, M. B., Davis, N., Ernstoff, M. S., Faries, M. B., Gold, J. S., Guild, S., Gyorki, D. E., Khushalani, N. I., Meyers, M. O., Robert, C., Santinami, M., Sehdev, A., Sondak, V. K., Spurrier, G., Tsai, K. K., van Akkooi, A., & Funchain, P.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2020-11-20
Volume
38
Issue
33
Pages
3947-3970
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.20.00198
OpenAlex
W3013646646
Cited by
265
References
20
FWCI
13.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Systemic Therapy for Melanoma: ASCO Guideline. https://app.cochat.ai/papers/10.1200/jco.20.00198
The paper
Seth, R., Messersmith, H., Kaur, V., Kirkwood, J. M., Kudchadkar, R., McQuade, J. L., Provenzano, A., Swami, U., Weber, J., Alluri, K. C., Agarwala, S., Ascierto, P. A., Atkins, M. B., Davis, N., Ernstoff, M. S., Faries, M. B., Gold, J. S., Guild, S., Gyorki, D. E., . . . Funchain, P. (2020). Systemic Therapy for Melanoma: ASCO Guideline. Journal of Clinical Oncology. https://doi.org/10.1200/jco.20.00198

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.