The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Second Cancers Among Long-Term Survivors of Hodgkin’s Disease Diagnosed in Childhood and Adolescence
Abstract
PURPOSE: To quantify the risk of second cancers among long-term survivors of Hodgkin’s disease (HD) diagnosed before 21 years of age and to explore sex-, age-, and site-related differences. PATIENTS AND METHODS: We analyzed data from 5,925 pediatric HD patients, including 2,646 10-year and 755 20-year survivors, who were reported to 16 population-based cancer registries in North America and Europe between 1935 and 1994. RESULTS: A total of 157 solid tumors (observed/expected ratio [O/E] = 7.0; 95% confidence interval [CI], 5.9 to 8.2.) and 26 acute leukemias (O/E = 27.4; 95% CI, 17.9 to 40.2) were reported. Risk of solid tumors remained significantly increased among 20-year survivors (O/E = 6.6, observed [O] = 40, cumulative risk = 6.5%) and persisted for 25 years (O/E = 4.6, O = 15, cumulative risk = 11.7%). Temporal trends for cancers of thyroid, female breast, bone/connective tissue, stomach, and esophagus were consistent with the late effects of radiotherapy. Greater than 50-fold increased risks were observed for tumors of the thyroid and respiratory tract (one lung and one pleura) among children treated before age 10. At older ages (10 to 16 years), the largest number of second cancers occurred in the digestive tract (O/E = 19.3) and breast (O/E = 22.9). Risk of solid tumors increased with decreasing age at HD on a relative but not absolute scale. CONCLUSION: Children and adolescents treated for HD experience significantly increased risks of second cancers at various sites for 2 to 3 decades. Although our results reflect the late effects of past therapeutic modalities, they underscore the importance of lifelong follow-up of pediatric HD patients given early, more aggressive treatments.
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Citations
Cites
Cancer Incidence in Five Continents
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Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma
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Thyroid Cancer after Exposure to External Radiation: A Pooled Analysis of Seven Studies
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., Schneider, A. B., Tucker, M. A., & Boice, J. D. (2012) · Radiation Research · doi:10.1667/rrav05.1 · Cited by 1,124
Thyroid Cancer after Exposure to External Radiation: A Pooled Analysis of Seven Studies
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., Schneider, A. B., Tucker, M. A., & Boice, J. D. (1995) · Radiation Research · doi:10.2307/3579003 · Cited by 1,107
Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease
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Cancer Incidence in Atomic Bomb Survivors. Part II: Solid Tumors, 1958-1987
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Risk of Second Cancers after Treatment for Hodgkin's Disease
Tucker, M. A., Coleman, C. N., Cox, R. S., Varghese, A., & Rosenberg, S. A. (1988) · New England Journal of Medicine · doi:10.1056/nejm198801143180203 · Cited by 718
Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia
Chow, W.-H., Blot, W. J., Vaughan, T. L., Risch, H. A., Gammon, M. D., Stanford, J. L., Dubrow, R., Schoenberg, J. B., Mayne, S. T., Farrow, D. C., et al. (1998) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/90.2.150 · Cited by 626
Cited by
Late cardiotoxicity after treatment for Hodgkin lymphoma
Aleman, B. M. P., van den Belt-Dusebout, A. W., De Bruin, M. L., van 't Veer, M. B., Baaijens, M. H. A., Boer, J. P. D., Hart, A. A. M., Klokman, W. J., Kuenen, M. A., Ouwens, G. M., et al. (2007) · Blood · doi:10.1182/blood-2006-07-034405 · Cited by 746
Self-citationSigurdson, A. J., Ronckers, C. M., Mertens, A. C., Stovall, M., Smith, S. A., Liu, Y., Berkow, R. L., Hammond, S., Neglia, J. P., Meadows, A. T., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66695-0 · Cited by 366
Metadata
- Authors
- Metayer, C., Lynch, C. F., Clarke, E. A., Glimelius, B., Storm, H., Pukkala, E., Joensuu, T., van Leeuwen, F. E., van’t Veer, M. B., Curtis, R. E., Holowaty, E. J., Andersson, M., Wiklund, T., Gospodarowicz, M., & Travis, L. B.
- Venue
- Journal of Clinical Oncology
- Published
- 2000-06-12
- Volume
- 18
- Issue
- 12
- Pages
- 2435-2443
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1955391915
- Cited by
- 340
- References
- 38
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Metayer, C., Lynch, C. F., Clarke, E. A., Glimelius, B., Storm, H., Pukkala, E., Joensuu, T., van Leeuwen, F. E., van’t Veer, M. B., Curtis, R. E., Holowaty, E. J., Andersson, M., Wiklund, T., Gospodarowicz, M., & Travis, L. B. (2000). Second Cancers Among Long-Term Survivors of Hodgkin’s Disease Diagnosed in Childhood and Adolescence. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.12.2435
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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