The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Activity of Thalidomide in AIDS-Related Kaposi’s Sarcoma
Abstract
PURPOSE: To assess the toxicity and activity of oral thalidomide in Kaposi’s sarcoma (KS) in a phase II dose-escalation study. PATIENTS AND METHODS: Human immunodeficiency virus (HIV)–seropositive patients with biopsy-confirmed KS that progressed over the 2 months before enrollment received an initial dose of 200 mg/d of oral thalidomide in a phase II study. The dose was increased to a maximum of 1,000 mg/d for up to 1 year. Anti-HIV therapy was maintained during the study period. Toxicity, tumor response, immunologic and angiogenic factors, and virologic parameters were assessed. RESULTS: Twenty patients aged 29 to 49 years with a median CD4 count of 246 cells/mm 3(range, 14 to 646 cells/mm 3) were enrolled. All patients were assessable for toxicity, and 17 for response. Drowsiness in nine and depression in seven patients were the most frequent toxicities observed. Eight (47%; 95% confidence interval [CI], 23% to 72%) of the 17 assessable patients achieved a partial response, and an additional two patients had stable disease. Based on all 20 patients treated, the response rate was 40% (95% CI, 19% to 64%). The median thalidomide dose at the time of response was 500 mg/d (range, 400 to 1,000 mg/d). The median duration of drug treatment was 6.3 months, and the median time to progression was 7.3 months. CONCLUSION: Oral thalidomide was tolerated in this population at doses up to 1,000 mg/d for as long as 12 months and was found to induce clinically meaningful anti-KS responses in a sizable subset of the patients. Additional studies of this agent in KS are warranted.
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Cites
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Metadata
- Authors
- Little, R. F., Wyvill, K. M., Pluda, J. M., Welles, L., Marshall, V., Figg, W. D., Newcomb, F. M., Tosato, G., Feigal, E., Steinberg, S. M., Whitby, D., Goedert, J. J., & Yarchoan, R.
- Venue
- Journal of Clinical Oncology
- Published
- 2000-07-01
- Volume
- 18
- Issue
- 13
- Pages
- 2593-2602
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1946820747
- Cited by
- 290
- References
- 43
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Little, R. F., Wyvill, K. M., Pluda, J. M., Welles, L., Marshall, V., Figg, W. D., Newcomb, F. M., Tosato, G., Feigal, E., Steinberg, S. M., Whitby, D., Goedert, J. J., & Yarchoan, R. (2000). Activity of Thalidomide in AIDS-Related Kaposi’s Sarcoma. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.13.2593
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