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Cited by 531

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Final Results of a Randomized Phase III Trial of Sequential High-Dose Methotrexate, Fluorouracil, and Doxorubicin Versus Etoposide, Leucovorin, and Fluorouracil Versus Infusional Fluorouracil and Cisplatin in Advanced Gastric Cancer: A Trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group

Vanhoefer, Udo, Rougier, Philippe, Wilke, Hansjochen, Ducreux, Michel P., Lacave, Angel J., Van Cutsem, Eric, Planker, Manfred, Santos, José Guimaraes Dos, Piedbois, Pascal, Paillot, Bernard, Bodenstein, Heinrich, Schmoll, Hans-Jochen, Bleiberg, Harry, Nordlinger, Bernard, Couvreur, Marie-Laure, Baron, Benoit, Wils, Jacques A.·2000·Journal of Clinical Oncology
DOI 10.1200/jco.2000.18.14.2648
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Abstract

PURPOSE: To compare the efficacy and tolerability of etoposide, leucovorin, and bolus fluorouracil (ELF) or infusional fluorouracil plus cisplatin (FUP) with that of the reference protocol of fluorouracil, doxorubicin, and methotrexate (FAMTX) in advanced gastric cancer. PATIENTS AND METHODS: A total of 399 patients with advanced adenocarcinoma of the stomach were randomized and analyzed for toxicity, tumor response, and progression-free and overall survival. Only reviewed and confirmed responses were considered. The analysis of remission was based on assessable patients with documented measurable lesions. The intent-to-treat principle, log-rank test, and Cox regression model were used for the statistical analysis of time-to-event end points. RESULTS: The overall response rate for 245 eligible patients with measurable disease was 9% with ELF, 20% with FUP, and 12% with FAMTX, with no significant differences. One hundred twelve patients were eligible for efficacy in assessable, nonmeasurable disease. No change was observed in 66% of patients treated with ELF, 56% with FUP, and 55% with FAMTX. Two patients achieved a complete tumor regression (one each for ELF and FAMTX). With a median follow-up time of 4.5 years, the median survival times were 7.2 months with ELF, 7.2 months with FUP, and 6.7 months with FAMTX, respectively, with no significant differences. Nonhematologic and hematologic toxicities of ELF, FUP, and FAMTX were acceptable, with neutropenia being the major toxicity for all three regimens. Seven treatment-related deaths occurred (two with FUP and five with FAMTX). CONCLUSION: All three investigated regimens demonstrate modest clinical efficacy and should not be regarded as standard treatment for advanced gastric cancer. New strategies should be considered to achieve a better clinical efficacy in the treatment of advanced gastric cancer.

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Metadata

Authors
Vanhoefer, U., Rougier, P., Wilke, H., Ducreux, M. P., Lacave, A. J., Van Cutsem, E., Planker, M., Santos, J. G. D., Piedbois, P., Paillot, B., Bodenstein, H., Schmoll, H.-J., Bleiberg, H., Nordlinger, B., Couvreur, M.-L., Baron, B., & Wils, J. A.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2000-07-14
Volume
18
Issue
14
Pages
2648-2657
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2000.18.14.2648
OpenAlex
W1848862702
Cited by
531
References
14
FWCI
24.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Final Results of a Randomized Phase III Trial of Sequential High-Dose Methotrexate, Fluorouracil, and Doxorubicin Versus Etoposide, Leucovorin, and Fluorouracil Versus Infusional Fluorouracil and Cisplatin in Advanced Gastric Cancer: A Trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group. https://app.cochat.ai/papers/10.1200/jco.2000.18.14.2648
The paper
Vanhoefer, U., Rougier, P., Wilke, H., Ducreux, M. P., Lacave, A. J., Van Cutsem, E., Planker, M., Santos, J. G. D., Piedbois, P., Paillot, B., Bodenstein, H., Schmoll, H.-J., Bleiberg, H., Nordlinger, B., Couvreur, M.-L., Baron, B., & Wils, J. A. (2000). Final Results of a Randomized Phase III Trial of Sequential High-Dose Methotrexate, Fluorouracil, and Doxorubicin Versus Etoposide, Leucovorin, and Fluorouracil Versus Infusional Fluorouracil and Cisplatin in Advanced Gastric Cancer: A Trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.14.2648

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.