The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Survival of Patients With Resected N2 Non–Small-Cell Lung Cancer: Evidence for a Subclassification and Implications
Abstract
PURPOSE: Patients who suffer from non–small-cell lung cancer (NSCLC) with ipsilateral mediastinal lymph node involvement (N2) belong to a heterogeneous subgroup of patients. We analyzed the prognosis of patients with resected N2 NSCLC to propose homogeneous patient subgroups. PATIENTS AND METHODS: The present study comprised 702 consecutive patients from six French centers who underwent surgical resection of N2 NSCLC. Initially, two groups of patients were defined: patients with clinical N2 (cN2) and those with minimal N2 (mN2) disease were patients in whom N2 disease was and was not detected preoperatively at computed tomographic scan, respectively. RESULTS: The median duration of follow-up was 52 months (range, 18 to 120 months). A multivariate analysis using Cox regression identified four negative prognostic factors, namely, cN2 status (P < .0001), involvement of multiple lymph node levels (L2+; P < .0001), pT3 to T4 stage (P < .0001), and no preoperative chemotherapy (P < .01). For patients treated with primary surgery, 5-year survival rates were as follows: mN2, one level involved (mN2L1, n = 244): 34%; mN2, multiple level involvement (mN2L2+, n = 78): 11%; cN2L1 (n = 118): 8%; and cN2L2+ (n = 122): 3%. When only patients with mN2L1 disease were considered, the site of lymph node involvement according to the American Thoracic Society numbering system had no prognostic significance (P = .14). Preoperative chemotherapy was associated with a better prognosis for those with cN2 (P < .0001). Five-year survival rates were 18% and 5% for cN2 patients treated with and without preoperative chemotherapy, respectively. CONCLUSION: This study has identified homogeneous N2 NSCLC prognostic subgroups and suggests different therapeutic approaches according to the subgroup profile.
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Postmus, P. E., Brambilla, E., Chansky, K., Crowley, J., Goldstraw, P., Patz, E. F., & Yokomise, H. (2007) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31811f4703 · Cited by 1,594
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Metadata
- Authors
- Andre, F., Grunenwald, D., Pignon, J.-P., Dujon, A., Pujol, J. L., Brichon, P. Y., Brouchet, L., Quoix, E., Westeel, V., & Le Chevalier, T.
- Venue
- Journal of Clinical Oncology
- Published
- 2000-08-16
- Volume
- 18
- Issue
- 16
- Pages
- 2981-2989
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1962989085
- Cited by
- 484
- References
- 18
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Andre, F., Grunenwald, D., Pignon, J.-P., Dujon, A., Pujol, J. L., Brichon, P. Y., Brouchet, L., Quoix, E., Westeel, V., & Le Chevalier, T. (2000). Survival of Patients With Resected N2 Non–Small-Cell Lung Cancer: Evidence for a Subclassification and Implications. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.16.2981
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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