The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Change in Neurocognitive Functioning After Treatment With Cranial Radiation in Childhood
Open accessAbstract
Purpose: To evaluate the pattern of stability and change over time across multiple domains of neurocognitive function in radiated survivors of posterior fossa (PF) tumors. Patients and Methods: Thirty-four children (25 males) treated for malignant PF tumors were observed with serial clinical neuropsychologic assessments. Thirty patients were treated for medulloblastoma and four patients were treated for ependymoma. Twelve patients were treated with reduced-dose and 21 patients were treated with standard-dose cranial radiation. All patients received an additional boost to the PF. One patient was treated with PF radiation only. Standardized neuropsychologic tests were administered at different times after diagnosis for each child. The rate of change in scores was determined using a mixed model regression. Results: Results showed a 2- to 4-point decline per year in intelligence scores. For our relatively young sample, intellectual function declined quickly in the first few years after treatment, and then more gradually. Significant declines in visual-motor integration, visual memory, verbal fluency, and executive functioning were also documented. No decline was evident for verbal memory and receptive vocabulary. Conclusion: Cranial radiation is associated with a decline in multiple neurocognitive domains, with a few notable exceptions. Our results must be interpreted in the context of common limitations of clinical research, including patient variability, changes in test versions, small sample size, and clinical referral bias.
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— Tumors of the Central Nervous System
(2013) · Pediatric Radiotherapy Planning and Treatment · doi:10.1201/b14554-7 · Cited by 1,751
Peabody Picture Vocabulary Test--Third Edition
Dunn, L. M., & Dunn, L. M. (2012) · PsycTESTS Dataset · doi:10.1037/t15145-000 · Cited by 813
Packer, R. J., Goldwein, J., Nicholson, H. S., Vezina, L. G., Allen, J. C., Ris, M. D., Muraszko, K., Rorke, L. B., Wara, W. M., Cohen, B. H., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.7.2127 · Cited by 617
Ris, M. D., Packer, R., Goldwein, J., Jones-Wallace, D., & Boyett, J. M. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.15.3470 · Cited by 533
Palmer, S. L., Goloubeva, O., Reddick, W. E., Glass, J. O., Gajjar, A., Kun, L., Merchant, T. E., & Mulhern, R. K. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.8.2302 · Cited by 400
Mulhern, R. K., Kepner, J. L., Thomas, P. R., Armstrong, F. D., Friedman, H. S., & Kun, L. E. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.5.1723 · Cited by 395
Horton, A. M., Monahan, M. C., & Fennell, E. B. (2001) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/16.2.193 · Cited by 372
BUTLER, R. W., & COPELAND, D. R. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617701020112 · Cited by 320
Grill, J., Renaux, V. K., Bulteau, C., Viguier, D., Levy-Piebois, C., Sainte-Rose, C., Dellatolas, G., Raquin, M.-A., Jambaqué, I., & Kalifa, C. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00177-7 · Cited by 287
Schatz, J., Kramer, J. H., Ablin, A., & Matthay, K. K. (2000) · Neuropsychology · doi:10.1037//0894-4105.14.2.189 · Cited by 231
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Nieman, B. J., de Guzman, A. E., Gazdzinski, L. M., Lerch, J. P., Chakravarty, M. M., Pipitone, J., Strother, D., Fryer, C., Bouffet, E., Laughlin, S., et al. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.07.2293 · Cited by 62
Self-citationAn easy-to-use function to assess deep space radiation in human brains
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Metadata
- Authors
- Spiegler, B. J., Bouffet, E., Greenberg, M. L., Rutka, J. T., & Mabbott, D. J.
- Venue
- Journal of Clinical Oncology
- Published
- 2004-02-15
- Volume
- 22
- Issue
- 4
- Pages
- 706-713
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2148842308
- Cited by
- 409
- References
- 24
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Spiegler, B. J., Bouffet, E., Greenberg, M. L., Rutka, J. T., & Mabbott, D. J. (2004). Change in Neurocognitive Functioning After Treatment With Cranial Radiation in Childhood. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2004.05.186
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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