The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Impact of Total Lymph Node Count on Staging and Survival After Gastrectomy for Gastric Cancer: Data From a Large US-Population Database
Abstract
Background: Prognosis of potentially curable (M0), completely resected gastric cancer is primarily determined by pathologic T and N staging criteria. The optimal regional dissection extent during gastrectomy for gastric adenocarcinoma continues to be debated. Methods: A gastric cancer data set was created through structured queries to the Surveillance, Epidemiology, and End Results database (1973 to 1999). Relationships between the number of lymph nodes (LNs) examined and survival were analyzed for the stage subgroups T1/2N0, T1/2N1, T3N0, and T3N1. Results: In every stage subgroup, overall survival was highly dependent on the number of LNs examined. Multivariate prognostic variables in the T1/2N0M0 subgroup were number of LNs examined, age (for both, P < .0001), race (P = .0004), sex (P = .0006), and tumor size (P = .02). A linear trend for superior survival based on more LNs examined could be confirmed for all four stage subgroups. Baseline model–predicted 5-year survival with only one LN examined was 56% (T1/2N0), 35% (T1/2N1), 29% (T3N0), or 13% (T3N1). For every 10 extra LNs dissected, survival improved by 7.6% (T1/2N0), 5.7% (T1/2N1), 11% (T3N0), or 7% (T3N1). A cut-point analysis yielded the greatest survival difference at 10 LNs examined but continued to detect significantly superior survival differences for cut points at up to 40 LNs, always in favor of more LNs examined. Conclusion: Although the impact of stage migration versus improved regional disease control cannot be separated on basis of the available information, the data provide support in favor of extended lymphadenectomy during potentially curative gastrectomy for gastric cancer.
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,181
Regression Models and Life-Tables
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Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Jemal, A., Tiwari, R. C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., Feuer, E. J., & Thun, M. J. (2004) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.54.1.8 · Cited by 3,984
Macdonald, J. S., Smalley, S. R., Benedetti, J., Hundahl, S. A., Estes, N. C., Stemmermann, G. N., Haller, D. G., Ajani, J. A., Gunderson, L. L., Jessup, J. M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010187 · Cited by 3,475
Extended Lymph-Node Dissection for Gastric Cancer
Bonenkamp, J. J., Hermans, J., Sasako, M., Welvaart, K., Songun, I., Meyer, S., Plukker, J. T. M., Van Elk, P., Obertop, H., Gouma, D. J., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903253401202 · Cited by 1,583
for the Surgical Co-operative Group, Cuschieri, A., Weeden, S., Fielding, J., Bancewicz, J., Craven, J., Joypaul, V, Sydes, M., & Fayers, P. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690243 · Cited by 1,373
Relevant Prognostic Factors in Gastric Cancer: Ten-Year Results of the German Gastric Cancer Study
Siewert, J. R., Böttcher, K., Stein, H. J., & Roder, J. D. (1998) · Annals of Surgery · doi:10.1097/00000658-199810000-00002 · Cited by 1,083
Hartgrink, H. H., van de Velde, C. J. H., Putter, H., Bonenkamp, J. J., Klein Kranenbarg, E., Songun, I., Welvaart, K., van Krieken, J. H. J. M., Meijer, S., Plukker, J. T. M., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.08.026 · Cited by 918
Cited by
Chen, Q.-Y., Xie, J.-W., Zhong, Q., Wang, J.-B., Lin, J.-X., Lu, J., Cao, L.-L., Lin, M., Tu, R.-H., Huang, Z.-N., et al. (2020) · JAMA Surgery · doi:10.1001/jamasurg.2019.6033 · Cited by 300
Metadata
- Authors
- Smith, D. D., Schwarz, R. R., & Schwarz, R. E.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-10-01
- Volume
- 23
- Issue
- 28
- Pages
- 7114-7124
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2133241444
- Cited by
- 585
- References
- 20
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, D. D., Schwarz, R. R., & Schwarz, R. E. (2005). Impact of Total Lymph Node Count on Staging and Survival After Gastrectomy for Gastric Cancer: Data From a Large US-Population Database. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.14.621
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