Molecular markers of early pancreatic cancer

p53 Mutations in Human Cancers

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Cancer Statistics, 2005

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Pancreatitis and the Risk of Pancreatic Cancer

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Colorectal carcinoma antigens detected by hybridoma antibodies

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MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

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Hereditary Pancreatitis and the Risk of Pancreatic Cancer

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Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients

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Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer

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Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.

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Somatic mutations of the mitochondrial genome in human colorectal tumours

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Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

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Sarcoma arising in irradiated bone

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Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

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Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

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Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations

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Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments

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Untitled work

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Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer.

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BRCA2 germline mutations in familial pancreatic carcinoma

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Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays

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p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.

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Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach

Canto, M. I., Goggins, M., Yeo, C. J., Griffin, C., Axilbund, J. E., Brune, K., Ali, S. Z., Jagannath, S., Petersen, G. M., Fishman, E. K., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00244-7 · Cited by 448 · see citing works

Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.

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p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

Moskaluk, C. A., Hruban, R. H., & Kern, S. E. (1997) · PubMed · Cited by 429 · see citing works

Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.

Iacobuzio–Donahue, C. A., Ashfaq, R., Maitra, A., Adsay, V. N., Shen-Ong, G. L. C., Berg, K. D., Hollingsworth, M. A., Cameron, J. L., Yeo, C. J., Kern, S. E., et al. (2003) · PubMed · Cited by 415 · see citing works

AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma

DiMagno, E. P., Reber, H. A., & Tempero, M. A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70298-2 · Cited by 408 · see citing works

Hypermethylation of multiple genes in pancreatic adenocarcinoma.

Ueki, T., Toyota, M., Sohn, T. A., Yeo, C. J., Issa, J. J., Hruban, R. H., & Goggins, M. (2000) · PubMed · Cited by 407 · see citing works

Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

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Clinical usefulness of carbohydrate antigen 19‐9 as a screening test for pancreatic cancer in an asymptomatic population

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Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer

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Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray.

Han, H., Bearss, D. J., Browne, L. W., Calaluce, R., Nagle, R. B., & Hoff, D. D. V. (2002) · PubMed · Cited by 380 · see citing works

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.

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Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.

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Mesothelin-specific CD8+ T Cell Responses Provide Evidence of In Vivo Cross-Priming by Antigen-Presenting Cells in Vaccinated Pancreatic Cancer Patients

Thomas, A. M., SANTARSIERO, L., Lutz, E. R., Armstrong, T. D., Chen, Y.-C., Huang, L.-Q., Laheru, D. A., Goggins, M., Hruban, R. H., & Jaffee, E. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031435 · Cited by 347 · see citing works

Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets

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Protein Expression Profiles in Pancreatic Adenocarcinoma Compared with Normal Pancreatic Tissue and Tissue Affected by Pancreatitis as Detected by Two-Dimensional Gel Electrophoresis and Mass Spectrometry

Shen, J., Person, M. D., Zhu, J., Abbruzzese, J. L., & Li, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-3262 · Cited by 337 · see citing works

Evaluation of Serum Protein Profiling by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Detection of Prostate Cancer: I. Assessment of Platform Reproducibility

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Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.

Sato, N., Fukushima, N., Maitra, A., Matsubayashi, H., Yeo, C. J., Cameron, J. L., Hruban, R. H., & Goggins, M. (2003) · PubMed · Cited by 328 · see citing works

Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity

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Untitled work

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Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.

Sato, N., Maitra, A., Fukushima, N., van Heek, N. T., Matsubayashi, H., Iacobuzio–Donahue, C. A., Rosty, C., & Goggins, M. (2003) · PubMed · Cited by 308 · see citing works

Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.

Tersmette, A. C., Petersen, G. M., Offerhaus, G. J. A., Falatko, F. C., Brune, K. A., Goggins, M., Rozenblum, E., Wilentz, R. E., Yeo, C. J., Cameron, J. L., et al. (2001) · PubMed · Cited by 307 · see citing works

Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology.

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Signal in Noise: Evaluating Reported Reproducibility of Serum Proteomic Tests for Ovarian Cancer

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Cloning and Characterization of a Novel Member of the Transforming Growth Factor-β/Bone Morphogenetic Protein Family

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High-resolution characterization of the pancreatic adenocarcinoma genome

Aguirre, A. J., Brennan, C. W., Bailey, G., Sinha, R., Feng, B., Leo, C., Zhang, Y., Zhang, J., Gans, J. D., Bardeesy, N. M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402932101 · Cited by 277 · see citing works

Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization Mass Spectrometry

Koopmann, J., Zhang, Z., White, N., Rosenzweig, J. M., Fedarko, N. S., Jagannath, S. B., Canto, M. I., Yeo, C. J., Chan, D. W., & Goggins, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1167-3 · Cited by 277 · see citing works

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274 · see citing works

SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor–stromal interactions

Sato, N., Fukushima, N., Maehara, N., Matsubayashi, H., Koopmann, J., Su, G. H., Hruban, R. H., & Goggins, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206807 · Cited by 273 · see citing works

STK11/LKB1 Peutz-Jeghers Gene Inactivation in Intraductal Papillary-Mucinous Neoplasms of the Pancreas

Sato, N., Rosty, C., Jansen, M., Fukushima, N., Ueki, T., Yeo, C. J., Cameron, J. L., Iacobuzio–Donahue, C. A., Hruban, R. H., & Goggins, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63053-2 · Cited by 268 · see citing works

MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

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Lessons from Controversy: Ovarian Cancer Screening and Serum Proteomics

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Fanconi anemia gene mutations in young-onset pancreatic cancer.

van der Heijden, M. S., Yeo, C. J., Hruban, R. H., & Kern, S. E. (2003) · PubMed · Cited by 262 · see citing works

Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection

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The Human MitoChip: A High-Throughput Sequencing Microarray for Mitochondrial Mutation DetectionPreprint

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Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors.

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PLAB, a novel placental bone morphogenetic protein

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Aberrant Methylation of Preproenkephalin and p16 Genes in Pancreatic Intraepithelial Neoplasia and Pancreatic Ductal Adenocarcinoma

Fukushima, N., Sato, N., Ueki, T., Rosty, C., Walter, K., Wilentz, R. E., Yeo, C. J., Hruban, R. H., & Goggins, M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61104-2 · Cited by 225 · see citing works

Expression profiling of microdissected pancreatic adenocarcinomas

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p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study

Ahrendt, S. A., Hu, Y. C., Buta, M. R., McDermott, M., Benoit, N. E., Yang, S. C., Wu, L., & Sidransky, D. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.13.961 · Cited by 220 · see citing works

Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations.

Jones, J. B., Song, J. J., Hempen, P. M., Parmigiani, G., Hruban, R. H., & Kern, S. E. (2001) · PubMed · Cited by 219 · see citing works

Gene Expression Profiling Identifies Genes Associated with Invasive Intraductal Papillary Mucinous Neoplasms of the Pancreas

Sato, N., Fukushima, N., Maitra, A., Iacobuzio–Donahue, C. A., van Heek, N. T., Cameron, J. L., Yeo, C. J., Hruban, R. H., & Goggins, M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63178-1 · Cited by 205 · see citing works

A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.

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Comprehensive Proteomic Analysis of Human Pancreatic Juice

Grønborg, M., Bunkenborg, J., Kristiansen, T. Z., Jensen, O. N., Yeo, C. J., Hruban, R. H., Maitra, A., Goggins, M., & Pandey, A. (2004) · Journal of Proteome Research · doi:10.1021/pr0499085 · Cited by 197 · see citing works

Evaluation of Osteopontin as Biomarker for Pancreatic Adenocarcinoma

Koopmann, J., Fedarko, N. S., Jain, A., Maitra, A., Iacobuzio–Donahue, C. A., Rahman, A., Hruban, R. H., Yeo, C. J., & Goggins, M. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.487.13.3 · Cited by 195 · see citing works

Genetics of Pancreatic Cancer

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p53 and K-RAS alterations in pancreatic epithelial cell lesions.

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Role of tumour markers, cytogenetics

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Application of laser capture microdissection combined with two‐dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma

Shekouh, A., Thompson, C. C., Prime, W., Campbell, F., Hamlett, J., Herrington, C. S., Lemoine, N. R., Crnogorac‐Jurcevic, T., Buechler, M. W., Friess, H., et al. (2003) · PROTEOMICS · doi:10.1002/pmic.200300466 · Cited by 173 · see citing works

Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma

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Plasma Protein Profiling for Diagnosis of Pancreatic Cancer Reveals the Presence of Host Response Proteins

Koomen, J. M., Shih, L.-C. N., Coombes, K. R., Li, D., Xiao, L.-C., Fidler, I. J., Abbruzzese, J. L., & Kobayashi, R. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1110.11.3 · Cited by 163 · see citing works

Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.

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Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.

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Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma.

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Gene Expression Profiling of Tumor–Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts

Sato, N., Maehara, N., & Goggins, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0677 · Cited by 158 · see citing works

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