The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy
Open accessAbstract
Recent research in breast biology has provided support for the cancer stem-cell hypothesis. Two important components of this hypothesis are that tumors originate in mammary stem or progenitor cells as a result of dysregulation of the normally tightly regulated process of self-renewal. As a result, tumors contain and are driven by a cellular subcomponent that retains key stem-cell properties including self-renewal, which drives tumorigenesis and differentiation that contributes to cellular heterogeneity. Advances in stem-cell technology have led to the identification of stem cells in normal and malignant breast tissue. The study of these stem cells has helped to elucidate the origin of the molecular complexity of human breast cancer. The cancer stem-cell hypothesis has important implications for early detection, prevention, and treatment of breast cancer. Both hereditary and sporadic breast cancers may develop through dysregulation of stem-cell self-renewal pathways. These aberrant stem cells may provide targets for the development of cancer prevention strategies. Furthermore, because breast cancer stem cells may be highly resistant to radiation and chemotherapy, the development of more effective therapies for this disease may require the effective targeting of this cell population.
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1 retracted
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Self-citationGeneration of a functional mammary gland from a single stem cell
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Cited by
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611
Self-citationSulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
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Self-citationA Review of Therapeutic Effects of Curcumin
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Metadata
- Authors
- Kakarala, M., & Wicha, M. S.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-06-10
- Volume
- 26
- Issue
- 17
- Pages
- 2813-2820
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2085134335
- Cited by
- 403
- References
- 71
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- green
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