The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
Abstract
Purpose This multicenter phase II study was undertaken to investigate the efficacy and feasibility of gefitinib for patients with advanced non–small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations without indication for chemotherapy as a result of poor performance status (PS). Patients and Methods Chemotherapy-naïve patients with poor PS (patients 20 to 74 years of age with Eastern Cooperative Oncology Group PS 3 to 4, 75 to 79 years of age with PS 2 to 4, and ≥ 80 years of age with PS 1 to 4) who had EGFR mutations examined by the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method were enrolled and received gefitinib (250 mg/d) alone. Results Between February 2006 and May 2007, 30 patients with NSCLC and poor PS, including 22 patients with PS 3 to 4, were enrolled. The overall response rate was 66% (90% CI, 51% to 80%), and the disease control rate was 90%. PS improvement rate was 79% (P < .00005); in particular, 68% of the 22 patients improved from ≥ PS 3 at baseline to ≤ PS 1. The median progression-free survival, median survival time, and 1-year survival rate were 6.5 months, 17.8 months, and 63%, respectively. No treatment-related deaths were observed. Conclusion This is the first report indicating that EGFR mutation-positive patients with extremely poor PS benefit from first-line gefitinib. Because there previously has been no standard treatment for these patients with short life expectancy other than best supportive care, examination of EGFR mutations as a biomarker is recommended in this patient population.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Patients with PS 3-4 may also be offered an EGFR TKI, as they are likely to receive a similar clinical benefit to patients with good PS [II, A] [113].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [113]
Citations
Cites
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer
Schiller, J. H., Harrington, D., Belani, C. P., Langer, C., Sandler, A., Krook, J., Zhu, J., & Johnson, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011954 · Cited by 4,955
COMPARISON OF FOUR CHEMOTHERAPY REGIMENS FOR ADVANCED NON-SMALL-CELL LUNG CANCER
Chiller, J. O. H. S., Arrington, D. A. H., Elani, C. H. P. B., Anger, C., Andler, A. L. S., Rook, J. A. K., Hu, J., & Ohnson, D. A. H. J. (2002) · Cited by 3,730
Fukuoka, M., Yano, S., Giaccone, G., Tamura, T., Nakagawa, K., Douillard, J., Nishiwaki, Y., Vansteenkiste, J., Kudoh, S., Rischin, D., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.038 · Cited by 2,871
Kris, M. G., Natale, R. B., Herbst, R. S., Lynch, Jr., Prager, D., Belani, C. P., Schiller, J. H., Kelly, K., Spiridonidis, H., Sandler, A., et al. (2003) · JAMA · doi:10.1001/jama.290.16.2149 · Cited by 2,517
Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji055 · Cited by 2,377
Giaccone, G., Herbst, R. S., Manegold, C., Scagliotti, G. V., Rosell, R., Miller, V. A., Natale, R. B., Schiller, J. H., von Pawel, J., Pluzanska, A., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.08.001 · Cited by 1,712
Herbst, R. S., Giaccone, G., Schiller, J. H., Natale, R. B., Miller, V. A., Manegold, C., Scagliotti, G. V., Rosell, R., Oliff, I. A., Reeves, J. A., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.215 · Cited by 1,701
Pfister, D. G., Johnson, D. H., Azzoli, C. G., Sause, W. T., Smith, T. J., Baker, S., Olak, J., Stover, D. E., Strawn, J. R., Turrisi, A. T., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.053 · Cited by 1,411
Flagged first, then by citations
Research works printed but not linked: 1
- Arteaga CL, ASCO virtual meeting 2004
Cited by
Sorted by citations
Items 201–300 of 501
Masuda, T., Imai, H., Kuwako, T., Miura, Y., Yoshino, R., Kaira, K., Shimizu, K., Sunaga, N., Tomizawa, Y., Ishihara, S., et al. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1297-8 · Cited by 16
Tyrosine Kinase Inhibitors for the Elderly
Hohenforst‐Schmidt, W., Zarogoulidis, P., Steinheimer, M., Benhassen, N., Tsiouda, T., Baka, S., Yarmus, L. B., Stratakos, G. K., Organtzis, J., Pataka, A., et al. (2016) · Journal of Cancer · doi:10.7150/jca.14819 · Cited by 15
First-Line Management of EGFR-Mutated Advanced Lung Adenocarcinoma: Recent Developments
Liao, B.-C., Lin, C., & Yang, J. C. (2013) · Drugs · doi:10.1007/s40265-013-0020-8 · Cited by 16
Yin, Y., Geng, Y., Shao, Y., Hu, X., Li, W., Shu, Y., & Wang, Z.-X. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-126 · Cited by 15
Jiang, Q., Zhang, N., Ma, D., Tan, B., Hu, X., & Fang, X. (2019) · Medicine · doi:10.1097/md.0000000000016065 · Cited by 15
Iwama, E., Goto, Y., Murakami, H., Tsumura, S., Sakashita, H., Mori, Y., Nakagaki, N., Fujita, Y., Seike, M., Bessho, A., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2019-0728 · Cited by 15
Chen, Y.-L., Lu, C., Yang, S.-C., Su, W., Lin, Y.-L., Chen, W.-L., Huang, W., Su, W., Chow, N.-H., & Ho, C. (2014) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.05.007 · Cited by 15
Chien, C., & Chen, H.-J. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.11.110 · Cited by 15
Wei, Y., Huang, W.-T., Liu, T.-C., Shieh, J.-M., Chian, C., Wu, M., Chang, C.-C., Lin, C., Ko, J., Lin, C.-M., et al. (2019) · Journal of Cancer · doi:10.7150/jca.30507 · Cited by 15
Tanaka, H., Taima, K., Makiguchi, T., Nakagawa, J., Niioka, T., & Tasaka, S. (2021) · 癌症:英文版 · doi:10.1002/cac2.12124 · Cited by 15
Kim, H. J., Choi, E. Y., Jin, H. J., & Shin, K. (2014) · PubMed · Cited by 14
Reck, M. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.63 · Cited by 14
NCCN Guidelines Version 1.2015 Panel Members Non-Small Cell Lung Cancer
Ettinger, D. S., Kimmel, S., Wood, D. E., Akerley, W., Bazhenova, L. A., Borghaei, H., Camidge, D. R., Cheney, R. T., Chirieac, L. R., Jahan, T. M., et al. (2014) · Cited by 14
Tandjaoui-Lambiotte, Y., Akrour, Y., Gibelin, A., Gonzalez, F., Stoclin, A., Moreau, A., Jaubert, P., Oppenheimer, A., Duchemann, B., & Gaudry, S. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.06.079 · Cited by 14
Nakashima, K., Umeda, Y., Demura, Y., Takeda, T., Tada, T., Sato, M., Jikuya, N., Kurokawa, K., Sonoda, T., Yamaguchi, M., et al. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02508-2 · Cited by 14
Eccles, B., Geldart, T., Laurence, V., Bradley, K., & Lwin, M. T. (2011) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834011409096 · Cited by 14
Sakai, H., Hayashi, H., Iwasa, T., Hasegawa, Y., Takeda, M., & Nakagawa, K. (2017) · ESMO Open · doi:10.1136/esmoopen-2016-000104 · Cited by 14
Okuma, Y., Morikawa, K., Tanaka, H., Yokoyama, T., Itani, H., Horiuchi, K., Nakagawa, H., Takahashi, N., Bessho, A., Soejima, K., et al. (2018) · Thoracic Cancer · doi:10.1111/1759-7714.12923 · Cited by 14
Gounant, V., Lavolé, A., & Quoix, É. (2020) · Lung Cancer · doi:10.1016/j.lungcan.2020.04.025 · Cited by 14
PNA-mediated Real-Time PCR Clamping for Detection of EGFR Mutations
Choi, J., Cho, M.-H., Oh, M., Kim, H.-S., Kil, M.-S., & Park, H.-K. (2010) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2010.31.12.3525 · Cited by 14
Yoshida, K., Yatabe, Y., Jangchul, P., Ogawa, S., Park, J. Y., Shimizu, J., Horio, Y., Matsuo, K., Mitsudomi, T., & Hida, T. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0685-2 · Cited by 13
Rationale of a relaunch of gefitinib in Caucasian non-small cell lung cancer patients
Pircher, A., Ploner, F., Popper, H., & Hilbe, W. (2010) · Lung Cancer · doi:10.1016/j.lungcan.2010.01.017 · Cited by 13
Sekine, A., & Satoh, H. (2017) · Medical Oncology · doi:10.1007/s12032-017-0978-2 · Cited by 13
EGFR mutation-positive NSCLC: factors to consider when deciding first-line therapy
Hulo, P., Coupez, D., Denis, M. G., & Bennouna, J. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2020.1757439 · Cited by 14
Ninomaru, T., Okada, H., Fujishima, M., Irie, K., Fukushima, S., & Hata, A. (2021) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2021.100145 · Cited by 13
Miyawaki, T., Kenmotsu, H., Kodama, H., Nishioka, N., Miyawaki, E., Mamesaya, N., Kobayashi, H., Omori, S., Ko, R., Wakuda, K., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08983-2 · Cited by 13
Gefitinib for non-small-cell lung cancer treatment
D’Incecco, A., & Cappuzzo, F. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.617738 · Cited by 13
Kurishima, K., Satoh, H., Kaburagi, T., Nishimura, Y., Shinohara, Y., Inagaki, M., Endo, T., Saito, T., Hayashihara, K., Hizawa, N., et al. (2013) · Molecular and Clinical Oncology · doi:10.3892/mco.2013.154 · Cited by 13
Riggs, H., Jalal, S. I., Baghdadi, T. A., Bhatia, S., McClean, J., Johnson, C. S., Yu, M., Taber, D. A., Harb, W. A., & Hanna, N. H. (2012) · Clinical Lung Cancer · doi:10.1016/j.cllc.2012.09.004 · Cited by 13
Successful treatment with afatinib after gefitinib- and erlotinib-induced hepatotoxicity
Ueda, H., Hayashi, H., Kudo, K., Takeda, M., & Nakagawa, K. (2016) · Investigational New Drugs · doi:10.1007/s10637-016-0384-1 · Cited by 13
Brouns, A., Dursun, S., Bootsma, G. P., Dingemans, A. C., & Hendriks, L. E. L. (2021) · Cancers · doi:10.3390/cancers13133144 · Cited by 13
Current and emerging medical treatments for non–small cell lung cancer: A primer for pulmonologists
Mazzone, P. J., & Mekhail, T. M. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.10.016 · Cited by 15
Hirasawa, Y., Kubota, Y., Mura, E., Suzuki, R., Tsurui, T., Iriguchi, N., Ishiguro, T., Ohkuma, R., Shimokawa, M., Ariizumi, H., et al. (2024) · Anticancer Research · doi:10.21873/anticanres.17160 · Cited by 12
Nakao, M., Muramatsu, H., Sone, K., AOKI, S., AKIKO, H., Kagawa, Y., Sato, H., & Kunieda, T. (2014) · Molecular and Clinical Oncology · doi:10.3892/mco.2014.453 · Cited by 12
Costanzo, R., Montanino, A., Maïo, M. D., Piccirillo, M. C., Sandomenico, C., Giordano, P., Daniele, G., Franco, R., Perrone, F., Rocco, G., et al. (2013) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2013.845092 · Cited by 12
Forest, F., Patoir, A., Col, P. D., Cruz, V. D., Camy, F., Stachowicz, M., Bayle-Bleuez, S., Fournel, P., Karpathiou, G., & Péoc’h, M. (2018) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000678 · Cited by 12
Noda‐Narita, S., Kawachi, A., Okuyama, A., Sadachi, R., Hirakawa, A., Goto, Y., Fujiwara, Y., Higashi, T., & Yonemori, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257489 · Cited by 12
Yamaguchi, T., Isogai, S., Okamura, T., Uozu, S., Mieno, Y., Hoshino, T., Gotô, Y., Hayashi, M., Nakanishi, T., & Imaizumi, K. (2015) · Case Reports in Oncology · doi:10.1159/000375485 · Cited by 12
Spigel, D. R., Greco, F. A., Thompson, D. S., Webb, C. D., Rubinsak, J. R., Inhorn, R. C., Reeves, J. E., Vázquez, E. R., Lane, C. M., Burris, H. A., et al. (2010) · Clinical Lung Cancer · doi:10.3816/clc.2010.n.026 · Cited by 12
Revannasiddaiah, S., Thakur, P., Bhardwaj, B., Susheela, S. P., & Madabhavi, I. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2014.05.19 · Cited by 11
Katayama, T., Matsuo, K., Kosaka, T., Sueda, T., Yatabe, Y., & Mitsudomi, T. (2010) · Surgical Oncology · doi:10.1016/j.suronc.2010.07.002 · Cited by 11
EGFR mutations in malignant pleural effusions from lung cancer
Shamblin, C. J., Tanner, N. T., Sanchez, R., Woolworth, J. A., & Silvestri, G. A. (2013) · Current Respiratory Care Reports · doi:10.1007/s13665-013-0041-5 · Cited by 11
Zaarour, M., Weerasinghe, C. K., Nazha, B., Hassan, S., & Atallah, J. P. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1092385 · Cited by 11
Colloca, G. A. (2021) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13598 · Cited by 11
Tanaka, H., Sakamoto, H., Akita, T., Ohyanagi, F., Kawashima, Y., Tambo, Y., Tanimoto, A., Horiike, A., Miyauchi, E., Tsuchiya‐Kawano, Y., et al. (2022) · Thoracic Cancer · doi:10.1111/1759-7714.14415 · Cited by 12
Hsia, T., Tu, C., & Chen, H.-J. (2014) · BMC Anesthesiology · doi:10.1186/1471-2253-14-55 · Cited by 11
Uemura, T., Oguri, T., Okayama, M., Furuta, H., Kanemitsu, Y., Takakuwa, O., Ohkubo, H., Takemura, M., Maeno, K., Ito, Y., et al. (2017) · Molecular and Clinical Oncology · doi:10.3892/mco.2017.1181 · Cited by 11
Sakamoto, S., Sato, K., Takita, Y., Izumiya, Y., Kumagai, N., Sudo, K., Hasegawa, Y., Yokota, H., Akamine, Y., Okuda, Y., et al. (2020) · Investigational New Drugs · doi:10.1007/s10637-020-00946-x · Cited by 11
Nasu, S., Suzuki, H., Shiroyama, T., Tanaka, A., Samejima, Y., Kanai, T., Noda, Y., Morishita, N., Okamoto, N., & Hirashima, T. (2020) · Investigational New Drugs · doi:10.1007/s10637-020-00963-w · Cited by 11
Harada, D., Isozaki, H., Kozuki, T., Yokoyama, T., Yoshioka, H., Bessho, A., Hosokawa, S., Takata, I., Takigawa, N., Hotta, K., et al. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.13825 · Cited by 11
Lee, I.-H., Yang, C., Shih, J., & Yu, C. (2021) · Biomedicines · doi:10.3390/biomedicines9101416 · Cited by 11
Kaburagi, T., Satoh, H., Hayashihara, K., Endo, T., Hizawa, N., Kurishima, K., Nishimura, Y., Hashimoto, T., Nakamura, H., Kishi, K., et al. (2012) · Oncology Letters · doi:10.3892/ol.2012.1048 · Cited by 11
A Survival Scoring System for Non-Small Cell Lung Cancer Patients with De Novo Bone Metastases
Chen, Y., Fang, Y.-T., Lai, C., Rau, K., Huang, C.-H., Chang, H., Chao, T.-Y., Tseng, C., Fang, W., Wang, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167923 · Cited by 11
Nonagase, Y., Takeda, M., Tanaka, K., Hayashi, H., Iwasa, T., & Nakagawa, K. (2018) · Oncotarget · doi:10.18632/oncotarget.25687 · Cited by 11
Togashi, Y., Hayashi, H., Nakagawa, K., & Nishio, K. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s50358 · Cited by 11
Noronha, V., Kapoor, A., Patil, V. M., Joshi, A., Menon, N. N., Chougule, A., Chandrani, P., Trivedi, V., Behel, V., Kumar, R., et al. (2020) · Cancer Research Statistics and Treatment · doi:10.4103/crst.crst_35_20 · Cited by 10
Lamy, T., Cabarrou, B., Planchard, D., Quantin, X., Schneider, S., Bringuier, M., Besse, B., Girard, N., CHOUAID, C., Filleron, T., et al. (2021) · Cancers · doi:10.3390/cancers14010092 · Cited by 10
Minuti, G., D’Incecco, A., & Cappuzzo, F. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0305-6 · Cited by 10
Arfaoui, A. T., Mahmoud, L. K. B., Znaidi, N. S., Gritli, S., Bouacha, H., Zermani, R., & Rammeh, S. (2013) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2013.848813 · Cited by 10
Are TKIs favourable for the elderly with non-small-cell lung cancer?
Rossi, S., D’Argento, E., Schinzari, G., Dadduzio, V., Noia, V. D., Cassano, A., & Barone, C. A. (2016) · Oncotarget · doi:10.18632/oncotarget.9389 · Cited by 10
Maclay, J. D., Farley, J., McCowan, C., Tweed, C., & Milroy, R. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.01.002 · Cited by 10
Nie, N., Liu, Z.-L., Feng, M., Liu, L., Luo, N., Li, L., & He, Y. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-2279 · Cited by 10
Flexible bronchoscopy for lung cancer diagnosis in patients aged ≥85 years
Mineshita, M., Morikawa, K., Furuya, N., Kida, H., Nishine, H., Handa, H., & Inoue, T. (2021) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14313 · Cited by 10
Immune Checkpoint Inhibitors in “Special” NSCLC Populations: A Viable Approach?
Bronte, G., Cosi, D. M., Magri, C., Frassoldati, A., Crinò, L., & Calabrò, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612622 · Cited by 10
Zukin, M. (2012) · Revista da Associação Médica Brasileira (English Edition) · doi:10.1590/s0104-42302012000200025 · Cited by 10
Kawaguchi, T., Tamiya, A., Tamura, A., Arao, M., Saito, R., Matsumura, A., Ou, S. I., & Tamura, T. (2012) · Clinical Lung Cancer · doi:10.1016/j.cllc.2012.03.010 · Cited by 10
KRAS Wild-Type Lung Cancer: A Moving Target in an Era of Genotype Migration
Oxnard, G. R., & Janne, P. A. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.2740 · Cited by 10
Saito, H., Nakagawa, K., Takeda, K., Iwamoto, Y., Ando, M., Maeda, M., Katakami, N., Nakano, T., Kurata, T., & Fukuoka, M. (2011) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e318201a0f3 · Cited by 9
Self-citationAddition of vandetanib to chemotherapy in advanced solid cancers
Wu, X., Jin, Y., Cui, I. H., Xu, Z., Zhang, Y., Zhang, X., Tang, C., Gong, Y., & Chen, J. (2012) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32835514f4 · Cited by 9
Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
Лактионов, К. К., Артамонова, Е. В., Borisova, T. N., Breder, V. V., Маркович, Б. Ю., Vladimirova, L. Y., Волков, Н. М., Ергнян, С. М., Жабина, А. С., Kononets, P. V., et al. (2022) · Journal of Modern Oncology · doi:10.26442/18151434.2022.3.201848 · Cited by 9
Morimoto, K., Yamada, T., Takeda, T., Shiotsu, S., Date, K., Tamiya, N., Gotô, Y., Kanda, H., Chihara, Y., Kunimatsu, Y., et al. (2023) · Targeted Oncology · doi:10.1007/s11523-023-00991-5 · Cited by 10
Tanaka, K., Hata, A., Kida, Y., Kaji, R., Fujita, S., Katakami, N., & Imai, Y. (2012) · Internal Medicine · doi:10.2169/internalmedicine.51.6386 · Cited by 9
Sakamoto, T., Kodani, M., Takata, M., Chikumi, H., Nakamoto, M., Nishii‐Ito, S., Ueda, Y., Izumi, H., Makino, H., Touge, H., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2875 · Cited by 9
Practice pearls in the management of lung cancer in the elderly
Kanesvaran, R., Chowdhury, A. R., & Krishna, L. K. R. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.05.004 · Cited by 9
Kim, J. S., Ryu, J., Jeon, S. H., Kim, H. J., Nam, H.-S., Cho, J. H., Kwak, S. M., & Lee, H. L. (2017) · Journal of International Medical Research · doi:10.1177/0300060517720099 · Cited by 9
Individualised treatment in non-small cell lung cancer: precise tissue diagnosis for all?
Booton, R., Blackhall, F. H., & Kerr, K. M. (2011) · Thorax · doi:10.1136/thx.2010.138370 · Cited by 9
Gijtenbeek, R. G. P., de Jong, K., Venmans, B. J. W., van Vollenhoven, F. H. M., Brinke, A. T., van der Wekken, A. J., & van Geffen, W. H. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013382.pub2 · Cited by 8
Lakkunarajah, S., Truong, P. T., Bone, J. N., Hughesman, C. B., Yip, S. S. F., Alex, D., Hart, J., Pollock, P., Egli, S., Clarkson, M., et al. (2023) · Translational Lung Cancer Research · doi:10.21037/tlcr-23-81 · Cited by 9
Positron Emission Tomography and Circulating Tumor Cells to Monitor a Dramatic Response to Gefitinib
Morabito, A., Sandomenico, C., Costanzo, R., Montanino, A., Caracò, C., Lutio, E. D., Bevilacqua, S., Pasquale, R., Caronna, A., Botti, G., et al. (2012) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3182653da2 · Cited by 8
Voon, P. J., Cho, B. C., Yeo, W.-L., & Soo, R. A. (2010) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2010.02.03.6 · Cited by 8
The role of Gefitinib in patients with non-small-cell lung cancer in India
Mehta, A. A., Jose, W. M., Pavithran, K., & Triavadi, G. (2013) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.110237 · Cited by 8
Takeda, T., Itano, H., Takeuchi, M., Nishimi, Y., Saitoh, M., & Takeda, S. (2017) · Respirology Case Reports · doi:10.1002/rcr2.241 · Cited by 8
Yamanaka, Y., Sekine, A., Kato, T., Yamakawa, H., Ikeda, S., Baba, T., Iwasawa, T., Okudela, K., & Ogura, T. (2017) · Internal Medicine · doi:10.2169/internalmedicine.8638-16 · Cited by 8
Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer
Okachi, S., Imaizumi, K., Imai, N., Shimizu, T., Hase, T., Morise, M., Hashimoto, N., Sato, M., & Hasegawa, Y. (2018) · European Geriatric Medicine · doi:10.1007/s41999-018-0033-7 · Cited by 8
Early Fatal Hemoptysis After First-Dose, in a Central Lung Cancer: Did Tumor Shrinkage Matter?
Facchinetti, F., Majori, M., Sabato, M., Gnetti, L., & Tiseo, M. (2019) · Immunotherapy · doi:10.2217/imt-2018-0136 · Cited by 8
Higashiyama, R. I., Yoshida, T., Jo, H., Shirasawa, M., Motoi, N., & Ohe, Y. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13713 · Cited by 8
Takamizawa, S., Okuma, Y., Kato, Y. X., Hakozaki, T., Kitagawa, S., & Zenke, Y. (2021) · Future Oncology · doi:10.2217/fon-2021-0947 · Cited by 8
Saito, A., Terai, H., Kim, T. J., Emoto, K., Kawano, R., Nakamura, K., Hayashi, H., Takaoka, H., Ogata, A., Kinoshita, K., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.7077 · Cited by 7
Minemura, H., Yokouchi, H., Azuma, K., Hirai, K.-I., Sekine, S., Oshima, K., Kanazawa, K., Tanino, Y., Inokoshi, Y., Ishii, T., et al. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1214-9 · Cited by 7
Vincenten, J. P. L., Smit, E. F., Grünberg, K., Postmus, P. E., Snijders, P. J. F., Lissenberg-Witte, B. I., Heideman, D. A. M., & Thunnissen, E. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.04.005 · Cited by 7
Lie, C.-H., Chang, H., Chao, T.-Y., Chung, Y., Wang, J.-L., Wang, C., & Lin, M. (2011) · Clinical Lung Cancer · doi:10.1016/j.cllc.2011.03.006 · Cited by 7
Sim, S. H., Kim, Y. J., Kim, S. H., Keam, B., Kim, T. M., Lee, S., Kim, D., Heo, D. S., & Lee, J. S. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1875-0 · Cited by 7
Hata, A., Katakami, N., Fujita, S., Nanjo, S., Takeshita, J., Tanaka, K., Kaneda, T., Nishiyama, A., Nishimura, T., Nakagawa, A., et al. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2755-2 · Cited by 7
Self-citationHotta, K., Kiura, K., Takigawa, N., Suzuki, E., Yoshioka, H., Okada, T., Kishino, D., Ueoka, H., Inoue, K., Tabata, M., et al. (2010) · Lung Cancer · doi:10.1016/j.lungcan.2010.03.008 · Cited by 7
Impact of Cytological Sampling on EGFR Mutation Testing in Stage III-IV Lung Adenocarcinoma
Davies, R. S., Smith, C., Edwards, G., Butler, R., Parry, D., & Lester, J. F. (2017) · Lung Cancer International · doi:10.1155/2017/9614938 · Cited by 7
Kanai, O., Kim, Y. H., Nakatani, K., Fujita, K., & Mio, T. (2017) · Clinical Case Reports · doi:10.1002/ccr3.973 · Cited by 7
Nishii, Y., Hataji, O., Ito, K., Watanabe, F., Kobayashi, T., D’Alessandro‐Gabazza, C. N., Toda, M., Taguchi, O., Yamamoto, N., & Gabazza, E. C. (2017) · Molecular and Clinical Oncology · doi:10.3892/mco.2017.1522 · Cited by 7
Kashiwabara, K., Fujii, S., Tsumura, S., & Sakamoto, K. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03344-1 · Cited by 7
Takenaka, T., Inamasu, E., Yoshida, T., Toyokawa, G., Nosaki, K., Hirai, F., Yamaguchi, M., Seto, T., Takenoyama, M., & Ichinose, Y. (2015) · Surgery Today · doi:10.1007/s00595-015-1200-9 · Cited by 7
Suda, K., Tomizawa, K., Mizuuchi, H., Ito, S., Kitahara, H., Shimamatsu, S., Kohno, M., Yoshida, T., Okamoto, T., Maehara, Y., et al. (2012) · Europe PMC (PubMed Central) · Cited by 7
Metadata
- Authors
- Inoue, A., Kobayashi, K., Usui, K., Maemondo, M., Okinaga, S., Mikami, I., Ando, M., Yamazaki, K., Saijo, Y., Gemma, A., Miyazawa, H., Tanaka, T., Ikebuchi, K., Nukiwa, T., Morita, S., & Hagiwara, K.
- Affiliations
- Tohoku University (JP)
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2009-03-20
- Volume
- 27
- Issue
- 9
- Pages
- 1394-1400
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2111191667
- Cited by
- 505
- References
- 32
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 18 · 2022: 22 · 2021: 33 · 2020: 25 · 2019: 22 · 2018: 29 · 2017: 35 · 2016: 34 · 2015: 31 · 2014: 30 · 2013: 43 · 2012: 41
- FWCI
- 45.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- gefitinib, advanced non-small cell lung cancer, EGFR mutation, first-line therapy, poor performance status, chemotherapy-naive patients, EGFR mutation testing, overall response rate, progression-free survival, best supportive care
- MeSH terms
- Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Middle Aged, Mutation, Prospective Studies, Young Adult, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review