Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer
Abstract
BACKGROUND: We conducted a randomized study to determine whether any of three chemotherapy regimens was superior to cisplatin and paclitaxel in patients with advanced non-small-cell lung cancer. METHODS: A total of 1207 patients with advanced non-small-cell lung cancer were randomly assigned to a reference regimen of cisplatin and paclitaxel or to one of three experimental regimens: cisplatin and gemcitabine, cisplatin and docetaxel, or carboplatin and paclitaxel. RESULTS: The response rate for all 1155 eligible patients was 19 percent, with a median survival of 7.9 months (95 percent confidence interval, 7.3 to 8.5), a 1-year survival rate of 33 percent (95 percent confidence interval, 30 to 36 percent), and a 2-year survival rate of 11 percent (95 percent confidence interval, 8 to 12 percent). The response rate and survival did not differ significantly between patients assigned to receive cisplatin and paclitaxel and those assigned to receive any of the three experimental regimens. Treatment with cisplatin and gemcitabine was associated with a significantly longer time to the progression of disease than was treatment with cisplatin and paclitaxel but was more likely to cause grade 3, 4, or 5 renal toxicity (in 9 percent of patients, vs. 3 percent of those treated with cisplatin plus paclitaxel). Patients with a performance status of 2 had a significantly lower rate of survival than did those with a performance status of 0 or 1. CONCLUSIONS: None of four chemotherapy regimens offered a significant advantage over the others in the treatment of advanced non-small-cell lung cancer.
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- Authors
- Schiller, J. H., Harrington, D., Belani, C. P., Langer, C., Sandler, A., Krook, J., Zhu, J., & Johnson, D. H.
- Affiliations
- University of Wisconsin–Madison (US)
- Dana-Farber Cancer Institute (US)
- UPMC Hillman Cancer Center (US)
- Fox Chase Cancer Center (US)
- Indiana University Indianapolis (US)
- Duluth Clinic (US)
- Vanderbilt University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-01-10
- Volume
- 346
- Issue
- 2
- Pages
- 92-98
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2037139573
- Cited by
- 4,955
- References
- 0
- Citations by year
- 2026: 81 · 2025: 66 · 2024: 85 · 2023: 134 · 2022: 145 · 2021: 145 · 2020: 171 · 2019: 190 · 2018: 208 · 2017: 229 · 2016: 238 · 2015: 267 · 2014: 282 · 2013: 287 · 2012: 276
- FWCI
- 171.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-23318, U10CA023318)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- advanced non-small cell lung cancer, chemotherapy regimens, cisplatin, paclitaxel, gemcitabine, docetaxel, carboplatin, nephrotoxicity, time to progression, survival, performance status
- MeSH terms
- Docetaxel, Gemcitabine, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Cisplatin, Deoxycytidine, Female, Humans, Lung Neoplasms, Male, Middle Aged, Survival Analysis, Paclitaxel, Disease-Free Survival, Taxoids
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